Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and mitoxantrone

sorafenib has been researched along with mitoxantrone in 6 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(mitoxantrone)		Trials
(mitoxantrone)		Recent Studies (post-2010) (mitoxantrone)
6,5207305,2514,5551,0421,004

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)mitoxantrone (IC50)
Chain A, Probable serine/threonine-protein kinase pknBMycobacterium tuberculosis H37Rv0.8
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))2.049
rac GTPase-activating protein 1 isoform aHomo sapiens (human)14.46
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)3.5619
Epidermal growth factor receptorHomo sapiens (human)5.3859
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.0352
Tyrosine-protein kinase FynHomo sapiens (human)1.2579
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)4.9898
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.219
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.6441
ATP-dependent translocase ABCB1Homo sapiens (human)1.501
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)2.9987
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.7487
DNA topoisomerase 2-alphaHomo sapiens (human)5.3
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)1.7853
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)3.5849
Casein kinase II subunit alpha'Homo sapiens (human)0.66
Sodium-dependent noradrenaline transporter Homo sapiens (human)4.9898
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.5619
Multidrug resistance-associated protein 1 Homo sapiens (human)0.0081
Casein kinase II subunit betaHomo sapiens (human)0.66
Casein kinase II subunit alphaHomo sapiens (human)0.66
Tyrosine-protein kinase BTKHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.5849
TAR DNA-binding protein 43Homo sapiens (human)10
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)3.5849
Integrase Human immunodeficiency virus 15.9
Multidrug and toxin extrusion protein 2Homo sapiens (human)0.68
Casein kinase II subunit alpha 3Homo sapiens (human)0.66
Multidrug and toxin extrusion protein 1Homo sapiens (human)0.3733
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)3.39
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.9038

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Huang, N; Li, L; Li, W; Wan, X; Xie, Y; Zhang, W1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Hou, T; Li, Y; Ma, Y; Peng, H; Ren, Z; Wei, Y; Zhao, Q1
Bitran, JD; Cygan, P; Galvez, AG; Lestingi, TM; Meyer, A; Nabhan, C; Tolzien, K1
Abkowitz, JL; Appelbaum, JS; Becker, PS; Cassaday, RD; Estey, EH; Garcia, KA; Ghiuzeli, MC; Halpern, AB; Hendrie, PC; Keel, SB; Oehler, VG; Orozco, JJ; Othus, M; Percival, MM; Rodríguez-Arbolí, E; Scott, BL; Walter, RB1

Reviews

1 review(s) available for sorafenib and mitoxantrone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for sorafenib and mitoxantrone

ArticleYear
Role of sorafenib in overcoming resistance of chemotherapy-failure castration-resistant prostate cancer.
    Clinical genitourinary cancer, 2014, Volume: 12, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Resistance, Neoplasm; Humans; Male; Middle Aged; Mitoxantrone; Niacinamide; Phenylurea Compounds; Prostatic Neoplasms, Castration-Resistant; Sorafenib; Survival Analysis; Taxoids; Treatment Failure

2014
Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML.
    Blood advances, 2023, 09-12, Volume: 7, Issue:17

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cytarabine; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Sorafenib

2023

Other Studies

3 other study(ies) available for sorafenib and mitoxantrone

ArticleYear
A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Drug Approval; Fungal Proteins; Genomics; Humans; Ligands; Mitogen-Activated Protein Kinases; Mitoxantrone; Molecular Docking Simulation; Protein Conformation; Protein Kinase Inhibitors; Substrate Specificity

2013
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
New use for an old drug: inhibiting ABCG2 with sorafenib.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:8

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzenesulfonates; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Mitoxantrone; Molecular Conformation; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Protein Binding; Pyridines; Signal Transduction; Sorafenib

2012