Page last updated: 2024-09-05

sorafenib and methyl-thiohydantoin-tryptophan

sorafenib has been researched along with methyl-thiohydantoin-tryptophan in 3 studies

Compound Research Comparison

Studies (sorafenib)	Trials (sorafenib)	Recent Studies (post-2010) (sorafenib)	Studies (methyl-thiohydantoin-tryptophan)	Trials (methyl-thiohydantoin-tryptophan)	Recent Studies (post-2010) (methyl-thiohydantoin-tryptophan)
6,520	730	5,251	376	1	348

Protein Interaction Comparison

Protein	Taxonomy	sorafenib (IC50)	methyl-thiohydantoin-tryptophan (IC50)
Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)		0.11
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)		0.6937

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Chen, F; Zhuang, C	1
Anichini, A; Carbone, A; Carlo-Stella, C; Cleris, L; Locatelli, SL; Malorni, W; Pierdominici, M; Saba, E; Stirparo, GG; Tartari, S	1

Reviews

1 review(s) available for sorafenib and methyl-thiohydantoin-tryptophan

Article	Year
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. Journal of medicinal chemistry, 2020, 02-27, Volume: 63, Issue:4 Topics: Animals; Cell Line, Tumor; Drug Development; Humans; Molecular Structure; Necroptosis; Protein Kinase Inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases	2020

Other Studies

2 other study(ies) available for sorafenib and methyl-thiohydantoin-tryptophan

Article	Year
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013
BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts. Leukemia, 2014, Volume: 28, Issue:9 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carbamates; Cell Line, Tumor; Histone Deacetylase Inhibitors; Hodgkin Disease; Humans; Imidazoles; Indoles; Membrane Proteins; Mice; Mice, SCID; Necrosis; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Reactive Oxygen Species; Sorafenib; Up-Regulation; Xenograft Model Antitumor Assays	2014

Article

Year

Identification of potent Yes1 kinase inhibitors using a library screening approach.

Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013

BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts.

Leukemia, 2014, Volume: 28, Issue:9

Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carbamates; Cell Line, Tumor; Histone Deacetylase Inhibitors; Hodgkin Disease; Humans; Imidazoles; Indoles; Membrane Proteins; Mice; Mice, SCID; Necrosis; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Reactive Oxygen Species; Sorafenib; Up-Regulation; Xenograft Model Antitumor Assays

2014