sorafenib has been researched along with melatonin in 4 studies
| Studies (sorafenib) | Trials (sorafenib) | Recent Studies (post-2010) (sorafenib) | Studies (melatonin) | Trials (melatonin) | Recent Studies (post-2010) (melatonin) |
|---|---|---|---|---|---|
| 6,520 | 730 | 5,251 | 23,268 | 1,451 | 9,627 |
| Protein | Taxonomy | sorafenib (IC50) | melatonin (IC50) |
|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | 3 | |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | 3.3323 | |
| Metabotropic glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.0004 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Melatonin receptor type 1A | Homo sapiens (human) | 0.0025 | |
| Melatonin receptor type 1B | Homo sapiens (human) | 0.0035 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baulies, A; Fernández, A; Fernández-Checa, JC; Garcia-Ruiz, C; González-Gallego, J; Mauriz, JL; Méndez-Blanco, C; Ordóñez, R; Prieto-Domínguez, N | 1 |
| Gao, C; Herr, I; Hoffmann, K; Lin, S; Petrulionis, M; Schemmer, P | 1 |
| Fang, Z; Han, B; Hong, SS; Jung, KH; Kang, YW; Kim, SJ; Lee, JE; Lim, JH; Park, JH; Rumman, M; Yan, HH | 1 |
| Fan, L; Liu, J; Lu, Q; Sun, G; Wang, H; Wang, Y; Wei, W; Zhou, B | 1 |
4 other study(ies) available for sorafenib and melatonin
| Article | Year |
|---|---|
Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy.
Topics: Apoptosis; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Melatonin; Mitophagy; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Reactive Oxygen Species; Sorafenib | 2016 |
Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.
Topics: Anthracenes; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 4; Melatonin; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Signal Transduction; Sorafenib | 2017 |
Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway.
Topics: Cell Line, Tumor; Drug Synergism; Humans; Melatonin; Neoplasm Proteins; Niacinamide; Pancreatic Neoplasms; Phenylurea Compounds; Receptor, Platelet-Derived Growth Factor alpha; Receptors, Melatonin; Signal Transduction; Sorafenib; STAT3 Transcription Factor | 2018 |
Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway.
Topics: Activating Transcription Factor 4; Autophagy; Beclin-1; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Flow Cytometry; Fluorescent Antibody Technique; Hep G2 Cells; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Liver Neoplasms; Melatonin; Microscopy, Electron, Transmission; Signal Transduction; Sorafenib; Tissue Array Analysis | 2019 |