Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and mangostin

sorafenib has been researched along with mangostin in 3 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(mangostin)		Trials
(mangostin)		Recent Studies (post-2010) (mangostin)
6,5207305,2514353352

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)mangostin (IC50)
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZYersinia pseudotuberculosis YPIII6.9
Maltase-glucoamylase, intestinalHomo sapiens (human)5.7
Lysine-specific histone demethylase 1AHomo sapiens (human)2.81
Lysosomal alpha-glucosidaseHomo sapiens (human)5.7
Sucrase-isomaltase, intestinalHomo sapiens (human)5.7
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)3.1
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)5.5
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)0.58
Phosphoglycerate mutase 1Homo sapiens (human)7.2
Delta-type opioid receptorMus musculus (house mouse)0.58
7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)0.47
Fatty acid synthaseHomo sapiens (human)5.54
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.58
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.31
Probable maltase-glucoamylase 2Homo sapiens (human)5.7
Cyclic GMP-AMP synthaseHomo sapiens (human)0.004
MAP/microtubule affinity-regulating kinase 4Homo sapiens (human)1.77

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Chen, H; Fisher, DE; Li, Y; Sun, J; Westover, KD; Xia, Y; Zhang, J1
Antarianto, RD; Arozal, W; Louisa, M; Rahmaniah, R; Soetikno, V; Yuyuntia, Y1
Chen, ZH; Hong, YF; Huang, HQ; Jia, CC; Li, Y; Wang, TT; Wu, DH; Wu, XY; Zhang, Q1

Other Studies

3 other study(ies) available for sorafenib and mangostin

ArticleYear
Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Cell Line, Tumor; Cell Proliferation; Genes, ras; Humans; Melanoma; Niacinamide; Phenylurea Compounds; Receptors, Retinoic Acid; Sorafenib; Xanthones

2016
Alpha mangostin Inhibits Hepatic Stellate Cells Activation Through TGF-β/Smad and Akt Signaling Pathways: An in vitro Study in LX2.
    Drug research, 2018, Volume: 68, Issue:3

    Topics: Actins; Animals; Biomarkers; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type I, alpha 1 Chain; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Ki-67 Antigen; Male; Niacinamide; Phenylurea Compounds; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Smad3 Protein; Sorafenib; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Xanthones

2018
Synergistic effects of α-Mangostin and sorafenib in hepatocellular carcinoma: New insights into α-mangostin cytotoxicity.
    Biochemical and biophysical research communications, 2021, 06-18, Volume: 558

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Gene Expression; Humans; Liver Neoplasms; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Kinase Inhibitors; RNA-Seq; Sorafenib; TOR Serine-Threonine Kinases; Ubiquitin-Protein Ligases; Xanthones; Xenograft Model Antitumor Assays

2021