Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and gw-5074

sorafenib has been researched along with gw-5074 in 4 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(gw-5074)		Trials
(gw-5074)		Recent Studies (post-2010) (gw-5074)
6,5207305,25183051

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)gw-5074 (IC50)
Serine/threonine-protein kinase PLK4Homo sapiens (human)0.23
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.0078
Cytochrome P450 3A4Homo sapiens (human)0.23
Serine/threonine-protein kinase A-RafHomo sapiens (human)0.0146
Serine/threonine-protein kinase B-rafHomo sapiens (human)0.0102
Serine/threonine-protein kinase PLK1Homo sapiens (human)4.6
Casein kinase II subunit alphaHomo sapiens (human)0.279
Dual specificity tyrosine-phosphorylation-regulated kinase 4Homo sapiens (human)4.38
Kinesin-like protein KIF15Homo sapiens (human)2.5
Mitogen-activated protein kinase kinase kinase 20Homo sapiens (human)1.89
Receptor-interacting serine/threonine-protein kinase 3Homo sapiens (human)5.4

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aman, W; Hah, JM; Jung, K; Kim, H; Kim, M; Lee, J; Ryu, JS1
Aziz, SA; Camp, RL; Conrad, PJ; Jilaveanu, LB; Kluger, HM; Rimm, DL; Schmitz, JC; Sznol, M; Zito, CR1
Caldwell, GA; Caldwell, KA; Dawson, TM; Dawson, VL; Hamamichi, S; Lee, BD; Liu, Z; Ray, A; Smith, WW; Yang, D1
Cha, TL; Chang, SY; Chen, MR; Chen, YC; Chuang, MJ; Ho, JY; Hsiao, PW; Huang, SM; Lee, HJ; Lin, CC; Lin, HK; Lin, VC; Sun, GH; Tang, SH; Tsai, YT; Wu, ST; Yu, CP; Yu, DS1

Other Studies

4 other study(ies) available for sorafenib and gw-5074

ArticleYear
Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyrimidines; Structure-Activity Relationship; U937 Cells

2014
C-Raf is associated with disease progression and cell proliferation in a subset of melanomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Sep-15, Volume: 15, Issue:18

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzenesulfonates; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cohort Studies; Disease Progression; Female; Gene Silencing; Humans; Indoles; Male; Melanoma; Middle Aged; Nevus; Niacinamide; Phenols; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; RNA, Small Interfering; Sensitivity and Specificity; Skin Neoplasms; Sorafenib; Young Adult

2009
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
    Human molecular genetics, 2011, Oct-15, Volume: 20, Issue:20

    Topics: Animals; Animals, Genetically Modified; Benzenesulfonates; Caenorhabditis elegans; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Enzyme Activation; Humans; Indoles; Motor Activity; Mutation; Niacinamide; Oxidopamine; Parkinson Disease; Phenols; Phenotype; Phenylurea Compounds; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sorafenib; Synucleins

2011
Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy.
    Cancer research, 2015, Sep-01, Volume: 75, Issue:17

    Topics: Aged; Animals; Apoptosis; Cell Line, Tumor; Death-Associated Protein Kinases; Disease-Free Survival; Drug Synergism; Female; Gene Knockout Techniques; Humans; Indoles; Kidney Neoplasms; Male; Mice; Middle Aged; Mitochondria; Niacinamide; Phenols; Phenylurea Compounds; Phosphorylation; Proto-Oncogene Proteins c-raf; Reactive Oxygen Species; Signal Transduction; Sorafenib; Xenograft Model Antitumor Assays

2015