Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and fisetin

sorafenib has been researched along with fisetin in 3 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(fisetin)		Trials
(fisetin)		Recent Studies (post-2010) (fisetin)
6,5207305,2516674507

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)fisetin (IC50)
Chain B, Cell division protein kinase 6Homo sapiens (human)0.85
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.79
Cyclin-dependent kinase 1Homo sapiens (human)0.79
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.85
Pyruvate kinase PKMHomo sapiens (human)0.9
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.79
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)0.6575
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)1.4
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)0.95
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)0.6575
Casein kinase II subunit alpha'Homo sapiens (human)0.5667
Cyclin-dependent kinase 2Homo sapiens (human)5
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-123.5
Xanthine dehydrogenase/oxidaseHomo sapiens (human)4.33
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.42
Glycogen synthase kinase-3 betaHomo sapiens (human)0.42
Mitogen-activated protein kinase 10Homo sapiens (human)2.65
Casein kinase II subunit betaHomo sapiens (human)0.5667
Casein kinase II subunit alphaHomo sapiens (human)0.5667
Cyclin-dependent kinase 6Homo sapiens (human)0.696
Cyclin-dependent-like kinase 5 Homo sapiens (human)0.64
Cyclin homologHerpesvirus saimiri (strain 11)0.6575
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)0.64
Mitogen-activated protein kinase 14Homo sapiens (human)2.65
Integrase Human immunodeficiency virus 18.5
Casein kinase II subunit alpha 3Homo sapiens (human)0.35
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.79
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)1
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)4.1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)2
Aurora kinase BHomo sapiens (human)2.63
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)0.6575

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afaq, F; Agarwal, J; Athar, M; Baxter, RD; Elmets, CA; Hunt, KM; Pal, HC1
Afaq, F; Athar, M; Diamond, AC; Elmets, CA; Kappes, JC; Katiyar, SK; Pal, HC; Strickland, LR1
Cheng, CW; Hsieh, YH; Lin, CL; Lin, MT; Lin, TY; Tsai, JP; Wu, CC; Yang, SF1

Other Studies

3 other study(ies) available for sorafenib and fisetin

ArticleYear
Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Flavonoids; Flavonols; Humans; Immunohistochemistry; Melanoma; Mice, Nude; Mitogen-Activated Protein Kinases; Mutation; Niacinamide; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays

2015
Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma.
    Oncotarget, 2016, Jan-12, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cadherins; Cell Line, Tumor; Cell Movement; Cells, Cultured; Drug Synergism; Epithelial-Mesenchymal Transition; Female; Flavonoids; Flavonols; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melanoma; Mice, Nude; Mutation; Neoplasm Invasiveness; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins B-raf; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays

2016
Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:5

    Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Synergism; Female; Flavonoids; Flavonols; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Niacinamide; Phenylurea Compounds; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Sorafenib; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2016