sorafenib has been researched along with erastin in 15 studies
| Studies (sorafenib) | Trials (sorafenib) | Recent Studies (post-2010) (sorafenib) | Studies (erastin) | Trials (erastin) | Recent Studies (post-2010) (erastin) |
|---|---|---|---|---|---|
| 6,520 | 730 | 5,251 | 212 | 0 | 203 |
| Protein | Taxonomy | sorafenib (IC50) | erastin (IC50) |
|---|---|---|---|
| Cystine/glutamate transporter | Homo sapiens (human) | 0.18 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 7 (46.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dixon, SJ; Gleason, CE; Hayano, M; Lee, ED; Patel, DN; Skouta, R; Slusher, BS; Stockwell, BR; Tatonetti, NP; Thomas, AG; Welsch, M | 1 |
| Baert, M; Chauffert, B; Diouf, M; Galmiche, A; Godin, C; Lachaier, E; Louandre, C; Saidak, Z | 1 |
| Buchfelder, M; Eyüpoglu, IY; Rauh, M; Savaskan, NE; Sehm, T; Wiendieck, K | 1 |
| Chen, D; Eyupoglu, IY; Savaskan, N | 1 |
| Bai, T; Sun, Y; Wang, S; Wang, W; Zhao, Y; Zhu, R | 1 |
| Bartlett, DL; Choudry, HA; Jeong, SY; Lee, DH; Lee, YJ; Lee, YS; Oh, SC; Park, SH; Park, YS; Yu, J | 1 |
| Kang, R; Liu, J; Tang, D; Wen, Q; Zhou, B | 1 |
| Bai, T; Lei, P; Liang, R; Sun, Y; Wang, W; Zhou, H; Zhou, L; Zhu, R | 1 |
| Capelletti, MM; Manceau, H; Peoc'h, K; Puy, H | 1 |
| Gan, B; Koppula, P; Zhuang, L | 1 |
| Ai, Y; Cao, Y; Ma, Y; Sun, Q; Wang, J; Wang, X; Yan, B; Zhang, Z | 1 |
| Balalaeva, IV; Krysko, DV; Mishchenko, TA; Vedunova, MV | 1 |
| Conrad, M; Mishima, E; Proneth, B; Sato, H; Sato, M; Zheng, J | 1 |
| Chang, JC; Chen, D; Chen, MM; Chen, X; Deng, Y; Gan, B; Hang, Q; Liang, H; Liu, X; Ma, L; Martinez, C; Mei, Y; Rosato, RR; Su, X; Sun, Y; Teng, H; Wang, Y; Xie, D; Yao, F; Yap, S; You, MJ; Zhang, M; Zhang, Y; Zhao, Y; Zhu, H | 1 |
| Cui, Z; Jiang, T; Li, C; Li, L; Li, S; Ma, J; Qin, T; Shi, H; Tang, T; Wang, H; Xu, W; Zhou, H | 1 |
2 review(s) available for sorafenib and erastin
| Article | Year |
|---|---|
Ferroptosis in Liver Diseases: An Overview.
Topics: alpha-Tocopherol; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Cyclohexylamines; Cysteine; Ferroptosis; Glutathione; Heme; Humans; Iron; Kelch-Like ECH-Associated Protein 1; Lipid Peroxidation; Lipoxygenase; Liver Diseases; Liver Neoplasms; Oxidative Stress; Phenylenediamines; Phospholipid Hydroperoxide Glutathione Peroxidase; Piperazines; Quinoxalines; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Sorafenib; Spiro Compounds; Sulfasalazine; Tumor Suppressor Protein p53 | 2020 |
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Topics: Amino Acid Transport System y+; Antineoplastic Agents; Cystine; DNA Methylation; Ferroptosis; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glutathione; Histones; Humans; Molecular Targeted Therapy; Neoplasms; Piperazines; Signal Transduction; Sorafenib; Sulfasalazine | 2021 |
13 other study(ies) available for sorafenib and erastin
| Article | Year |
|---|---|
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.
Topics: 20-Hydroxysteroid Dehydrogenases; Amino Acid Transport System y+; Apoptosis; Biomarkers; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cystine; Endoplasmic Reticulum Stress; Glutamic Acid; Humans; Iron; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Sequence Analysis, RNA; Sorafenib; Structure-Activity Relationship; Transcriptome; Up-Regulation | 2014 |
Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Humans; L-Lactate Dehydrogenase; Necrosis; Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Sorafenib; Tumor Cells, Cultured | 2014 |
Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis.
Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Astrocytes; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; Gene Knockdown Techniques; Glioma; Humans; Mice; Niacinamide; Phenylurea Compounds; Piperazines; Pyramidal Cells; Rats; Sorafenib; Temozolomide | 2016 |
Ferroptosis and Cell Death Analysis by Flow Cytometry.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dactinomycin; Flow Cytometry; Humans; Indicators and Reagents; Iron; Necrosis; Niacinamide; Phenylurea Compounds; Piperazines; Propidium; Rats; Sorafenib | 2017 |
Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Dose-Response Relationship, Drug; Haloperidol; Humans; Iron; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Receptors, sigma; Sigma-1 Receptor; Sorafenib; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Artesunate; Colonic Neoplasms; Drug Synergism; Endoplasmic Reticulum Stress; Female; Ferroptosis; Gene Knockdown Techniques; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Piperazines; Proto-Oncogene Proteins; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sorafenib; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP; Tumor Burden; Tumor Suppressor Protein p53; Up-Regulation; Xenograft Model Antitumor Assays | 2019 |
The release and activity of HMGB1 in ferroptosis.
Topics: Animals; Autophagy; Carbolines; Cell Death; Cell Line, Tumor; Chloroquine; Ferritins; Fibroblasts; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Iron Overload; Lipid Peroxidation; Macrolides; Mice; Neoplasms; Oximes; Piperazines; Sorafenib; Sulfonamides; Toll-Like Receptor 4 | 2019 |
Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Ferroptosis; Hep G2 Cells; Humans; Lipid Peroxidation; Liver Neoplasms; Mice; Piperazines; Reactive Oxygen Species; Receptors, sigma; Sigma-1 Receptor; Sorafenib; Up-Regulation | 2019 |
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.
Topics: Animals; Cell Line, Tumor; Cell Membrane; Concanavalin A; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Electron Transport; Fatty Acids, Unsaturated; Ferroptosis; HEK293 Cells; HeLa Cells; Humans; Hydrogen Peroxide; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; NADP; Oxygen; Phenylurea Compounds; Piperazines; Pyridines; Sorafenib | 2021 |
Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment.
Topics: Animals; Carbolines; Cell Line, Tumor; Chlorophyllides; Ferroptosis; Humans; Mice; Nanoparticle Drug Delivery System; Neoplasms; Photochemotherapy; Photosensitizing Agents; Piperazines; Reactive Oxygen Species; Sorafenib; Treatment Outcome | 2021 |
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.
Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Ferroptosis; HEK293 Cells; Humans; Mice; Neoplasms; Piperazines; Protein Kinase Inhibitors; Sorafenib; Sulfasalazine | 2021 |
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
Topics: Animals; Antibodies, Neutralizing; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Ferroptosis; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Leukemia Inhibitory Factor Receptor alpha Subunit; Lipocalin-2; Liver Neoplasms; Male; Mice, Inbred C57BL; NF-kappa B; Piperazines; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Signal Transduction; Sorafenib; Up-Regulation; Xenograft Model Antitumor Assays | 2021 |
Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin.
Topics: Animals; Antimalarials; Artemisinins; Cell Death; Female; Ferroptosis; Humans; Malaria; Mice; Mice, Inbred C57BL; Parasites; Piperazines; Reactive Oxygen Species; Sorafenib | 2022 |