sorafenib has been researched along with dextromethorphan in 3 studies
| Studies (sorafenib) | Trials (sorafenib) | Recent Studies (post-2010) (sorafenib) | Studies (dextromethorphan) | Trials (dextromethorphan) | Recent Studies (post-2010) (dextromethorphan) |
|---|---|---|---|---|---|
| 6,520 | 730 | 5,251 | 2,020 | 342 | 593 |
| Protein | Taxonomy | sorafenib (IC50) | dextromethorphan (IC50) |
|---|---|---|---|
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | 1.3 | |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | 1.3 | |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | 1.3 | |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 5.6 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 2.1768 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.0027 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 0.1236 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chen, D; Goh, WH; Soh, CK; Wang, H | 1 |
| Flaherty, KT; Frye, RF; Lathia, C; O'Dwyer, PJ; Redlinger, M; Rosen, M; Schuchter, L | 1 |
1 review(s) available for sorafenib and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for sorafenib and dextromethorphan
| Article | Year |
|---|---|
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.
Topics: Antineoplastic Agents; Area Under Curve; Benzenesulfonates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Isoenzymes; Melanoma; Midazolam; Niacinamide; Omeprazole; Phenylurea Compounds; Pyridines; Sorafenib | 2011 |
1 other study(ies) available for sorafenib and dextromethorphan
| Article | Year |
|---|---|
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2018 |