sorafenib has been researched along with GDC-0879 in 4 studies
| Studies (sorafenib) | Trials (sorafenib) | Recent Studies (post-2010) (sorafenib) | Studies (GDC-0879) | Trials (GDC-0879) | Recent Studies (post-2010) (GDC-0879) |
|---|---|---|---|---|---|
| 6,520 | 730 | 5,251 | 10 | 0 | 9 |
| Protein | Taxonomy | sorafenib (IC50) | GDC-0879 (IC50) |
|---|---|---|---|
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | 0.2003 | |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | 0.063 | |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | 0.063 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandhuber, BJ; Buckmelter, AJ; Callejo, M; Grina, J; Laird, ER; Lyssikatos, J; Martinson, M; Miknis, G; Morales, T; Randolph, N; Rast, B; Ren, L; Schlachter, S; Tarlton, E; Vigers, G; Welch, M; Wenglowsky, S | 1 |
| Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP | 1 |
| Kim, J; Wang, X | 1 |
| Agianian, B; Gavathiotis, E | 1 |
1 review(s) available for sorafenib and GDC-0879
| Article | Year |
|---|---|
Current Insights of BRAF Inhibitors in Cancer.
Topics: Animals; Drug Discovery; Humans; Mutation; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf | 2018 |
3 other study(ies) available for sorafenib and GDC-0879
| Article | Year |
|---|---|
The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Topics: Animals; Binding Sites; Cell Line, Tumor; Computer Simulation; Drug Evaluation, Preclinical; Humans; Indans; Microsomes, Liver; Models, Chemical; Models, Molecular; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridines; Rats; Structure-Activity Relationship | 2011 |
Comprehensive analysis of kinase inhibitor selectivity.
Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity | 2011 |
Conformation-specific effects of Raf kinase inhibitors.
Topics: Dimerization; Models, Molecular; Protein Conformation; Protein Kinase Inhibitors; raf Kinases | 2012 |