Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine

sorafenib has been researched along with 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine in 2 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine)		Trials
(7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine)		Recent Studies (post-2010) (7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine)
6,5207305,25162062

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine (IC50)
High affinity nerve growth factor receptorHomo sapiens (human)1.756
Tyrosine-protein kinase LckHomo sapiens (human)1.25
Tyrosine-protein kinase YesHomo sapiens (human)3.195
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)1.215
Cytochrome P450 3A4Homo sapiens (human)0.03
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.154
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)0.696
Tyrosine-protein kinase receptor UFOHomo sapiens (human)2.705
Cytochrome P450 2C19Homo sapiens (human)1.215
Serine/threonine-protein kinase Nek4Homo sapiens (human)1.402
Mitogen-activated protein kinase kinase kinase 9Homo sapiens (human)1.578
Mitogen-activated protein kinase kinase kinase 10Homo sapiens (human)0.452
Tyrosine-protein kinase MerHomo sapiens (human)0.474
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.0181
Protein-tyrosine kinase 6Homo sapiens (human)0.412
Inhibitor of nuclear factor kappa-B kinase subunit epsilonHomo sapiens (human)1.064
NT-3 growth factor receptorHomo sapiens (human)1.115
Mitogen-activated protein kinase kinase kinase 11Homo sapiens (human)1.14
BDNF/NT-3 growth factors receptorHomo sapiens (human)2.962
Discoidin domain-containing receptor 2Homo sapiens (human)0.524
Aurora kinase BHomo sapiens (human)0.407
Eukaryotic translation initiation factor 2-alpha kinase 1Homo sapiens (human)0.42
Myosin light chain kinase 2, skeletal/cardiac muscleHomo sapiens (human)0.701
Eukaryotic translation initiation factor 2-alpha kinase 3Homo sapiens (human)0.0152
Serine/threonine-protein kinase WNK2Homo sapiens (human)3.892
Mitogen-activated protein kinase kinase kinase kinase 5Homo sapiens (human)1.569

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Authors

AuthorsStudies
Chen, F; Zhuang, C1
Shi, K; Wang, J; Wang, Y; Zhang, J; Zhou, E1

Reviews

2 review(s) available for sorafenib and 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine

ArticleYear
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.
    Journal of medicinal chemistry, 2020, 02-27, Volume: 63, Issue:4

    Topics: Animals; Cell Line, Tumor; Drug Development; Humans; Molecular Structure; Necroptosis; Protein Kinase Inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases

2020
Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.
    Journal of medicinal chemistry, 2022, 11-24, Volume: 65, Issue:22

    Topics: Apoptosis; Chemistry, Pharmaceutical; Drug Discovery; Humans; Receptor-Interacting Protein Serine-Threonine Kinases

2022