sorafenib has been researched along with 2-methoxyestradiol in 3 studies
| Studies (sorafenib) | Trials (sorafenib) | Recent Studies (post-2010) (sorafenib) | Studies (2-methoxyestradiol) | Trials (2-methoxyestradiol) | Recent Studies (post-2010) (2-methoxyestradiol) |
|---|---|---|---|---|---|
| 6,520 | 730 | 5,251 | 779 | 11 | 315 |
| Protein | Taxonomy | sorafenib (IC50) | 2-methoxyestradiol (IC50) |
|---|---|---|---|
| Tubulin alpha-1A chain | Sus scrofa (pig) | 2.2 | |
| Tubulin beta chain | Sus scrofa (pig) | 2.2 | |
| Tubulin beta-2B chain | Bos taurus (cattle) | 3.48 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.0667 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Dong, X; Jiang, X; Li, G; Li, J; Ma, L; Ni, S; Qiao, H; Sun, X; Zhao, D; Zhu, H | 1 |
| Chen, GG; Ho, RL; Hu, B; Lai, PB; Lee, CG; Leung, BC; Liu, Y; Lu, G; Ren, J; Su, X; Wang, Y; Yang, S | 1 |
3 other study(ies) available for sorafenib and 2-methoxyestradiol
| Article | Year |
|---|---|
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2.
Topics: 2-Methoxyestradiol; Active Transport, Cell Nucleus; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hepatocellular; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; RNA Interference; Signal Transduction; Sorafenib; Time Factors; Transfection; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1A2; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Phenylurea Compounds; Receptors, Estrogen; Sorafenib; Tumor Suppressor Protein p53 | 2016 |