Page last updated: 2024-08-18

soman and tabun

soman has been researched along with tabun in 106 studies

Research

Studies (106)

TimeframeStudies, this research(%)All Research%
pre-199033 (31.13)18.7374
1990's24 (22.64)18.2507
2000's23 (21.70)29.6817
2010's23 (21.70)24.3611
2020's3 (2.83)2.80

Authors

AuthorsStudies
Dettbarn, WD; Gupta, RC1
Boulet, CA; Clement, JG; Hansen, AS1
Boulet, CA; Hand, BT; Hansen, AS; Lundy, PM1
Maxwell, DM1
Freeman, SE; Lau, WM; Szilagyi, M2
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG1
Bide, RW; Parker, D; Sawyer, TW; Thomas, N; Weiss, MT1
Baraka, A1
Erhard, MH; Kühlmann, R; Lösch, U; Szinicz, L1
Eldefrawi, AT; Eldefrawi, ME; Silveira, CL1
Goulet, JC; Hand, BT; Lundy, PM1
Dewey, WL; Tripathi, HL1
Hamilton, MG; Lundy, PM1
Jokanović, M2
Forster, JS; Hammond, PS1
Ho, IK; Hoskins, B; Liu, DD1
Ho, IK; Hoskins, B; Liu, DD; Watanabe, HK1
Boucher, LJ; Broomfield, CA; Fox-Talbot, MK; Lenz, DE; Little, JS; MacIver, B1
de Jong, LP; Hagedorn, I; Langenberg, JP; Löffler, M; Verhagen, MA1
Clement, JG; Gennings, C; Shiloff, JD1
Benschop, HP; De Bisschop, HC; Johnson, MK; Read, DJ; Willems, JL1
Pantelić, D1
Haraldsson, S; Lundberg, S; Marchner, H1
Artursson, E; Bucht, G; Puu, G1
Désiré, B; Saint-André, S2
Sipponen, KB1
Dawson, RM; Gray, PJ1
Dulaney, MD; Fernando, JC; Ho, IK; Hoskins, B; Lim, DK; Liu, DD; Watanabe, HK1
Beers, ET; Glenn, JF; Rickett, DL1
Kiffer, D; Minard, P1
Dulaney, MD; Ho, IK; Hoskins, B1
De Bisschop, HC; Nicaise, M; Willems, JL1
Hoskin, FC; Kirkish, MA; Steinmann, KE1
Ho, IK; Hoskins, B; Sivam, SP1
Beck, HC; Benschop, HP; Van den Berg, GR1
Binenfeld, Z; Maksimović, M; Markov, V1
Bosković, B; Jovanović, D; Kovacević, V1
Clement, JG; Filbert, M1
Clement, JG1
Melchers, BP; Philippens, IH; Wolthuis, OL1
Dawson, RM; Gray, PJ; Szilagyi, M1
Blank, JA; Fricke, RF; Hobson, DW; Koplovitz, I; Olson, CT; Rockwood, GA; Scharf, BA1
Koplovitz, I; Stewart, JR1
Ashani, Y; Cohen, E; Grunwald, J; Marcus, D; Papier, Y; Raveh, L1
Francisković, L; Reiner, E; Spoljar, MS1
Bruijnzeel, PL; Busker, RW; Melchers, BP; van Helden, HP1
Belkin, M; Solberg, Y1
Holstege, CP; Kirk, M; Sidell, FR1
Becker, G; Kawan, A; Szinicz, L1
Knopff, O; Szinicz, L; Widmann, R; Worek, F1
Cheng, TC; DeFrank, JJ; Rastogi, VK1
Maxwell, DM; Sweeney, RE1
Broomfield, CA; Platteborze, PL1
McDonough, JH; Shih, TM1
Hamazaki, T; Kataoka, M; Seto, Y; Takesako, H; Tsuge, K1
Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG1
Amundson, DE; Devereaux, A; Lazarus, AA; Parrish, JS1
HEILBRONN, E; TOLAGEN, B1
Niven, AS; Roop, SA1
Newmark, J1
Bajgar, J; Hájek, P; Krs, O; Slízová, D1
Calić, M; Jelić, D; Jun, D; Kovarik, Z; Kuca, K; Radić, B; Vrdoljak, AL1
Reiner, E; Simeon-Rudolf, V1
Kellar, KJ1
Calić, M; Kovarik, Z; Radić, B; Vrdoljak, AL1
Kassa, J1
Bajgar, J; Jun, D; Kuca, K1
Cerasoli, DM; Edwards, CC; Fleming, CD; Kirby, SD; Maxwell, DM; Potter, PM; Redinbo, MR1
Bajgar, J; Jun, D; Kassa, J; Kuca, K1
Dawson, RM; Kotsonis, SE; Pantelidis, S; Rose, HR1
Hrobak, PK1
Berend, S; Kuca, K; Radić, B; Vrdoljak, AL1
Bajgar, J; Jun, D; Karasova, J; Kassa, J; Kuca, K1
Barakat, NH; Beck, JM; Cashman, JR; Gilley, CB; Hadad, CM; MacDonald, M; Okolotowicz, K; Vyas, S; Zhang, J; Zheng, X1
Cashman, JR; Gilley, C; Lockridge, O; MacDonald, M; Nachon, F; Schopfer, LM; Zhang, J1
Dale, TJ; Rebek, J1
Baati, R; Gillon, E; Jean, L; Mercey, G; Nachon, F; Renard, PY; Saint-André, G; Verdelet, T; Wagner, A1
Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW1
Bird, M; Chad, JE; Green, AC; Price, M; Tattersall, JE; Timperley, CM; Turner, SR1
Berend, S; Katalinić, M; Kopjar, N; Kovarik, Z; Lovrić, J; Lucić Vrdoljak, A; Mesić, M; Radić, B; Rast, S; Želježić, D1
Bumm, R; Friess, H; Gerhardus, J; Langer, P; Mihaljevic, AL; Niessen, KV; Seeger, T; Thiermann, H; Worek, F1
Cerasoli, DM; Chilukuri, N; Harrison, J; Hodgins, SM; Kasten, SA; Oliver, ZP; Otto, TC; Reeves, TE; Rezk, P1
Bahnson, BJ; Cerasoli, DM; Kirby, SD; Norris, JR; Richard Smith, J1
Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R1
Thiermann, H; Wille, T; Worek, F1
Li, D; Li, J; Liu, X; Marriott, PJ; Rose, G1
Ringer, JM1
Barba-Bon, A; Costero, AM; Gil, S; Martínez-Máñez, R; Sancenón, F1
Cerasoli, DM; Dephillipo, T; Jones, JL; Kasten, SA; Zulli, S1
Ikeda, T; Kondo, T; Kurimata, N; Nagashima, H; Nagoya, T; Seto, Y; Unoke, S1
Kanamori-Kataoka, M; Seto, Y1
Aas, P; Enger, S; Mariussen, E; Myhrer, T1
Płusa, T; Sokołowski, R1
Caetano, MS; da Cunha, EF; de Castro, AA; Mancini, DT; Ramalho, TC; Rocha, EP; Silva, TC1
Cadieux, CL; Cerasoli, D; Koenig, JA; Koh, J; McDonough, J; Shih, TM; Wang, H; Zhang, Y1
Biyikal, M; Climent, E; Costero, AM; Dropa, T; Gawlitza, K; Martínez-Máñez, R; Rurack, K; Urban, M1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL1
da Cunha, EFF; de Castro, AA; Krejcar, O; Kuca, K; Leal, DHS; Mancini, DT; Pereira, AF; Ramalho, TC; Soares, FV1
Bai, X; Du, M; Gong, A; Huo, B; Lai, Y; Li, M; Shen, A; Yang, Y1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM1
Hughes, GT; Kelly, JT; Malloy, TA; Piatkowski, T; Qualley, A; Rubenstein, MH1
Leif, RN; Valdez, CA1

Reviews

13 review(s) available for soman and tabun

ArticleYear
Chemical warfare--the nerve gases.
    Middle East journal of anaesthesiology, 1991, Volume: 11, Issue:1

    Topics: Antidotes; Chemical Warfare Agents; Gas Poisoning; Humans; Organophosphate Poisoning; Organophosphates; Protective Clothing; Sarin; Soman

1991
Pharmacological effects of oximes: how relevant are they?
    Archives of toxicology, 1996, Volume: 70, Issue:12

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Organophosphate Poisoning; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Receptors, Cholinergic; Respiration; Soman; Synaptic Transmission

1996
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
    Trends in pharmacological sciences, 1997, Volume: 18, Issue:6

    Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission

1997
Chemical warfare. Nerve agent poisoning.
    Critical care clinics, 1997, Volume: 13, Issue:4

    Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman

1997
Alteromonas prolidase for organophosphorus G-agent decontamination.
    Chemico-biological interactions, 1999, May-14, Volume: 119-120

    Topics: Aryldialkylphosphatase; Chemical Warfare Agents; Decontamination; Dipeptidases; Esterases; Gram-Negative Aerobic Bacteria; Organophosphates; Organophosphorus Compounds; Sarin; Soman

1999
A review of nerve agent exposure for the critical care physician.
    Critical care medicine, 2002, Volume: 30, Issue:10

    Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman

2002
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.
    Postgraduate medicine, 2002, Volume: 112, Issue:4

    Topics: Antidotes; Arsenicals; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Information Services; Internet; Irritants; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Primary Prevention; Protective Clothing; Sarin; Soman

2002
Inhalational exposure to nerve agents.
    Respiratory care clinics of North America, 2004, Volume: 10, Issue:1

    Topics: Chemical Warfare Agents; Disaster Planning; Humans; Lung Diseases; Lung Injury; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman; United States

2004
Therapy for nerve agent poisoning.
    Archives of neurology, 2004, Volume: 61, Issue:5

    Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman

2004
Therapeutic and neuroprotective efficacy of pharmacological pretreatment and antidotal treatment of acute tabun or soman poisoning with the emphasis on pretreatment drug PANPAL.
    Arhiv za higijenu rada i toksikologiju, 2006, Volume: 57, Issue:4

    Topics: Animals; Antidotes; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Combinations; Neuroprotective Agents; Organophosphates; Pyridostigmine Bromide; Soman; Trihexyphenidyl

2006
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning.
    Toxicology, 2011, Jul-29, Volume: 285, Issue:3

    Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman

2011
[Today's threat of use of organophosphorus compounds].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2015, Volume: 39, Issue:231

    Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Environmental Exposure; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Seizures; Soman

2015
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
    Molecules (Basel, Switzerland), 2021, Jul-30, Volume: 26, Issue:15

    Topics: Alkylation; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methylation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman

2021

Other Studies

93 other study(ies) available for soman and tabun

ArticleYear
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
    Neurotoxicology, 1992,Fall, Volume: 13, Issue:3

    Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine

1992
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:3

    Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman

1992
Comparison of several oximes against poisoning by soman, tabun and GF.
    Toxicology, 1992, Volume: 72, Issue:1

    Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Soman

1992
The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds.
    Toxicology and applied pharmacology, 1992, Volume: 114, Issue:2

    Topics: Acetylcholinesterase; Animals; Brain; Carboxylic Ester Hydrolases; In Vitro Techniques; Kinetics; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Paraoxon; Rats; Rats, Inbred Strains; Sarin; Soman; Substrate Specificity

1992
Effects of some organophosphorus compounds on the binding of a radioligand (8-cyclopentyl 1, 3-[3H]dipropylxanthine) to adenosine receptors in ovine cardiac membranes.
    Journal of applied toxicology : JAT, 1991, Volume: 11, Issue:6

    Topics: Animals; Cholinesterase Inhibitors; In Vitro Techniques; Myocardium; Organophosphates; Potassium Channels; Receptors, Purinergic; Sarin; Sheep; Soman; Xanthines

1991
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:3

    Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl

1991
Efficacy of an oximate-based skin decontaminant against organophosphate nerve agents determined in vivo and in vitro.
    Toxicology, 1991, Volume: 67, Issue:3

    Topics: Acetylcholinesterase; Animals; Brain; Chick Embryo; Cholinesterase Inhibitors; Decontamination; Diacetyl; Female; Male; Neurons; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1991
Detection of the organophosphorus nerve agent soman by an ELISA using monoclonal antibodies.
    Archives of toxicology, 1990, Volume: 64, Issue:7

    Topics: Alcohols; Animals; Antibodies, Monoclonal; Antibody Specificity; Buffers; Chickens; Cholinesterase Inhibitors; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Goats; Humans; Mice; Mice, Inbred Strains; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Peroxidases; Rabbits; Soman; Stereoisomerism

1990
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
    Toxicology and applied pharmacology, 1990, Volume: 103, Issue:3

    Topics: Animals; Cholinesterase Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Echothiophate Iodide; Insecticides; Male; Myocardium; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sarin; Soman; Tritium

1990
Hormone- and dose schedule-dependent protection by HI-6 against soman and tabun poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 12, Issue:3

    Topics: Animals; Body Weight; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Male; Obidoxime Chloride; Orchiectomy; Organophosphates; Organophosphorus Compounds; Ovariectomy; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Species Specificity; Testosterone; Time Factors

1989
Comparison of the effects of diisopropylfluorophosphate, sarin, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice.
    Journal of toxicology and environmental health, 1989, Volume: 26, Issue:4

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Isoflurophate; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphates; Organophosphorus Compounds; Sarin; Soman

1989
HI-6 therapy of soman and tabun poisoning in primates and rodents.
    Archives of toxicology, 1989, Volume: 63, Issue:2

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Respiratory Muscles; Soman

1989
Role of carboxylesterase in soman, sarin and tabun poisoning in rats.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:3

    Topics: Animals; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Hydrogen-Ion Concentration; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Phenobarbital; Rats; Rats, Inbred Strains; Sarin; Soman; Tritolyl Phosphates

1989
A microassay-based procedure for measuring low levels of toxic organophosphorus compounds through acetylcholinesterase inhibition.
    Analytical biochemistry, 1989, Aug-01, Volume: 180, Issue:2

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Isoflurophate; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Reference Standards; Soman; Spectrophotometry

1989
Acute effects of soman, sarin, and tabun on microsomal and cytosolic components of the calmodulin system in rat striatum.
    Journal of neurochemistry, 1986, Volume: 46, Issue:1

    Topics: Adenylyl Cyclases; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Calmodulin; Corpus Striatum; Cytosol; Guanylate Cyclase; Microsomes; Organophosphates; Organophosphorus Compounds; Phosphoric Diester Hydrolases; Protein Kinases; Rats; Rats, Inbred Strains; Sarin; Soman

1986
Acute effects of Soman, Sarin, and Tabun on cyclic nucleotide metabolism in rat striatum.
    Journal of toxicology and environmental health, 1986, Volume: 19, Issue:1

    Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Male; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1986
Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP).
    Biochemical pharmacology, 1989, Jan-01, Volume: 38, Issue:1

    Topics: Animals; Hydrolases; Hydrolysis; Isoflurophate; Kinetics; Liver; Magnesium; Male; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman; Stereoisomerism

1989
The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman.
    Biochemical pharmacology, 1989, Feb-15, Volume: 38, Issue:4

    Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Eels; Humans; In Vitro Techniques; Organophosphates; Organophosphorus Compounds; Oximes; Pyridines; Pyridinium Compounds; Soman; Stereoisomerism; Structure-Activity Relationship

1989
Binding of some organophosphorus compounds at adenosine receptors in guinea pig brain membranes.
    Neuroscience letters, 1988, Nov-22, Volume: 94, Issue:1-2

    Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cholinesterase Inhibitors; Guinea Pigs; Kinetics; Organophosphates; Organophosphorus Compounds; Receptors, Purinergic; Sarin; Soman

1988
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.
    Archives of toxicology, 1987, Volume: 61, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman

1987
High doses of soman protect against organophosphorus-induced delayed polyneuropathy but tabun does not.
    Toxicology and applied pharmacology, 1988, Volume: 92, Issue:1

    Topics: Animals; Ataxia; Atropine; Carboxylic Ester Hydrolases; Chickens; Diazepam; Drug Interactions; Female; Isoflurophate; Isomerism; Organophosphates; Organophosphorus Compounds; Physostigmine; Soman

1988
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare].
    Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28

    Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman

1986
[The effect of inhibition and activation of ali-esterase on the acute toxicity of organophosphates in rats].
    Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28

    Topics: Acute Disease; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Enzyme Activation; Organophosphates; Organophosphorus Compounds; Rats; Sarin; Soman; Tritolyl Phosphates

1986
Organophosphorus anticholinesterases do not mediate analgesia through inhibition of enkephalin degradation.
    Life sciences, 1986, Apr-07, Volume: 38, Issue:14

    Topics: Acetylcholinesterase; Aminopeptidases; Analgesia; Animals; Brain; Cholinesterase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Leucine; Enkephalins; Isoflurophate; Male; Neprilysin; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman; Synaptosomes

1986
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
    Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism

1986
Inactivation of sarin and soman by cyclodextrins in vitro.
    Experientia, 1987, Apr-15, Volume: 43, Issue:4

    Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Dextrins; gamma-Cyclodextrins; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Starch

1987
Detector for organophosphorus compounds in liquid chromatography based on the cholinesterase inhibition reaction.
    Journal of chromatography, 1987, Feb-27, Volume: 389, Issue:1

    Topics: Acetylcholinesterase; Air; Animals; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Electrophorus; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Spectrophotometry, Ultraviolet

1987
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
    Toxicology and applied pharmacology, 1987, Volume: 91, Issue:1

    Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman

1987
Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.
    Toxicology letters, 1986, Volume: 30, Issue:2

    Topics: Animals; Cholinesterase Inhibitors; Corpus Striatum; Injections, Subcutaneous; Male; Mastication; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Seizures; Soman; Tremor

1986
Central respiratory effects versus neuromuscular actions of nerve agents.
    Neurotoxicology, 1986,Spring, Volume: 7, Issue:1

    Topics: Animals; Cats; Cholinesterase Inhibitors; Diaphragm; Female; Male; Neuromuscular Junction; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Respiratory Center; Respiratory Insufficiency; Sarin; Soman

1986
Reactivation by imidazo-pyridinium oximes of acetylcholinesterase inhibited by organophosphates. A study with an immobilized enzyme method.
    Biochemical pharmacology, 1986, Aug-01, Volume: 35, Issue:15

    Topics: Acetylcholinesterase; Enzymes, Immobilized; Kinetics; Organophosphates; Oximes; Pyridinium Compounds; Soman; Structure-Activity Relationship

1986
Interaction of soman with beta-cyclodextrin.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 7, Issue:4

    Topics: Acetylcholinesterase; Animals; beta-Cyclodextrins; Binding Sites; Cholinesterase Inhibitors; Cyclodextrins; Dextrins; Drug Interactions; Electrophorus; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Starch

1986
Studies on low dose sub-acute administration of soman, sarin and tabun in the rat.
    Acta pharmacologica et toxicologica, 1985, Volume: 57, Issue:4

    Topics: Acetylcholinesterase; Animals; Body Weight; Brain; Cholinesterase Inhibitors; Growth; Insecticides; Male; Organophosphates; Rats; Rats, Inbred Strains; Sarin; Soman; Time Factors

1985
Delayed neuropathy by the organophosphorus nerve agents soman and tabun.
    Archives of toxicology, 1984, Volume: 55, Issue:1

    Topics: Animals; Chickens; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Lethal Dose 50; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nervous System Diseases; Pyridinium Compounds; Soman

1984
Two enzymes for the detoxication of organophosphorus compounds--sources, similarities, and significance.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2

    Topics: Animals; Decapodiformes; Electrophorus; Escherichia coli; Esterases; Hydrolases; In Vitro Techniques; Isoflurophate; Kidney; Manganese; Mollusca; Nephropidae; Neurons; Organophosphates; Organophosphorus Compounds; Phosphoric Triester Hydrolases; Proteus vulgaris; Saccharomyces cerevisiae; Soman; Swine; Tetrahymena

1984
An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:4

    Topics: 4-Aminobutyrate Transaminase; Animals; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Corpus Striatum; Erythrocytes; gamma-Aminobutyric Acid; In Vitro Techniques; Isoflurophate; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Parasympathetic Nervous System; Rats; Rats, Inbred Strains; Sarin; Soman

1984
Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents.
    Bulletin of environmental contamination and toxicology, 1984, Volume: 33, Issue:5

    Topics: Cholinesterase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism

1984
[Direct reactions of pyridinium oximes with organophosphorus compounds].
    Arhiv za higijenu rada i toksikologiju, 1984, Volume: 35, Issue:3

    Topics: Chemical Phenomena; Chemical Warfare Agents; Chemistry; Drug Interactions; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Sarin; Soman

1984
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity

1984
Antidote effect of sodium fluoride against organophosphate poisoning in mice.
    Life sciences, 1983, Apr-18, Volume: 32, Issue:16

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Drug Interactions; Fluorides; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Sarin; Sodium Fluoride; Soman

1983
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat.
    Biochemical pharmacology, 1982, Apr-01, Volume: 31, Issue:7

    Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nerves; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1982
Treatment of nerve gas poisoning.
    The Medical letter on drugs and therapeutics, 1995, May-12, Volume: 37, Issue:948

    Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman

1995
Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4

    Topics: Animals; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Conditioning, Operant; Electroencephalography; Guinea Pigs; Lethal Dose 50; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiratory Mechanics; Soman

1994
Effects of the nerve agents soman and tabun on the uptake and release of GABA and glutamate in synaptosomes of guinea pig cerebral cortex.
    General pharmacology, 1993, Volume: 24, Issue:3

    Topics: Animals; Baclofen; Cerebral Cortex; Cholinesterase Inhibitors; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Neurotransmitter Agents; Organophosphates; Rats; Soman; Synaptosomes

1993
Efficacy of tacrine as a nerve agent pretreatment.
    Drug and chemical toxicology, 1994, Volume: 17, Issue:1

    Topics: Acetylcholinesterase; Animals; Behavior, Animal; Chemical Warfare Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Mice; Organophosphates; Sarin; Soman; Tacrine

1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
    Biochemical pharmacology, 1993, Jun-22, Volume: 45, Issue:12

    Topics: Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Neutralization Tests; Organophosphates; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman

1993
Interaction of imidazolium and pyridinium dioximes with human erythrocyte acetylcholinesterase.
    Chemico-biological interactions, 1993, Volume: 87, Issue:1-3

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Kinetics; Organophosphates; Oximes; Phosphorylation; Soman

1993
Direct reaction of oximes with sarin, soman, or tabun in vitro.
    Archives of toxicology, 1997, Volume: 71, Issue:11

    Topics: Antidotes; Cholinesterase Inhibitors; Half-Life; Organophosphates; Oximes; Sarin; Soman; Spectrophotometry, Ultraviolet

1997
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
    Archives of toxicology, 1998, Volume: 72, Issue:4

    Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman

1998
A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning.
    Mathematical biosciences, 1999, Volume: 160, Issue:2

    Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Esterases; Isoflurophate; Lethal Dose 50; Models, Biological; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Sarin; Soman

1999
Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni).
    Biotechnology and applied biochemistry, 2000, Volume: 31, Issue:3

    Topics: Animals; Baculoviridae; Butyrylcholinesterase; Cells, Cultured; Cholinesterase Inhibitors; COS Cells; Glycosylation; Humans; Hydrolysis; Larva; Lepidoptera; Organophosphates; Organophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman

2000
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
    Archives of toxicology, 2000, Volume: 74, Issue:3

    Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman

2000
Effect of pedological characteristics on aqueous soil extraction recovery and tert-butyldimethylsilylation yield for gas chromatography-mass spectrometry of nerve gas hydrolysis products from soils.
    Environmental science & technology, 2001, May-01, Volume: 35, Issue:9

    Topics: Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Hydrolysis; Organophosphates; Organophosphorus Compounds; Organosilicon Compounds; Sarin; Silanes; Soil Pollutants; Soman; Water

2001
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
    Biochemical pharmacology, 1965, Jan-01, Volume: 14

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology

1965
Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2004, Volume: 148, Issue:2

    Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Diaphragm; Motor Endplate; Organophosphate Poisoning; Organophosphates; Rats; Soman

2004
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.
    Toxicology, 2006, Feb-15, Volume: 219, Issue:1-3

    Topics: Acetylcholinesterase; Algorithms; Animals; Cell Line; Cell Survival; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Organophosphate Poisoning; Organophosphates; Oximes; Phosphorylation; Pyridinium Compounds; Soman

2006
Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman.
    Arhiv za higijenu rada i toksikologiju, 2006, Volume: 57, Issue:2

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Trimedoxime

2006
Overcoming inhibitions.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-05, Volume: 103, Issue:36

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors

2006
Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice.
    Journal of molecular neuroscience : MN, 2006, Volume: 30, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Erythrocytes; Humans; Mice; Organophosphates; Oximes; Pyridinium Compounds; Soman

2006
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime

2007
Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun.
    Biochemistry, 2007, May-01, Volume: 46, Issue:17

    Topics: Carboxylesterase; Chemical Warfare Agents; Crystallization; Crystallography, X-Ray; Humans; Models, Molecular; Organophosphates; Soman

2007
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:5

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Muscarinic Antagonists; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Soman

2007
Degradation of nerve agents by an organophosphate-degrading agent (OpdA).
    Journal of hazardous materials, 2008, Sep-15, Volume: 157, Issue:2-3

    Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Organophosphates; Organophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman

2008
Nerve agents: implications for anesthesia providers.
    AANA journal, 2008, Volume: 76, Issue:2

    Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors

2008
New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning.
    Chemico-biological interactions, 2008, Sep-25, Volume: 175, Issue:1-3

    Topics: Animals; Chemical Warfare Agents; Enzyme Reactivators; Humans; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Organophosphate Poisoning; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Soman

2008
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats.
    Chemico-biological interactions, 2008, Sep-25, Volume: 175, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Chemical Warfare Agents; Enzyme Reactivators; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Rats; Rats, Wistar; Soman

2008
Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.
    Chemical research in toxicology, 2009, Volume: 22, Issue:10

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Computer Simulation; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Sarin; Soman; Stereoisomerism

2009
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
    Chemical research in toxicology, 2009, Volume: 22, Issue:10

    Topics: Amino Acid Sequence; Butyrylcholinesterase; Catalytic Domain; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Molecular Sequence Data; Organophosphates; Organophosphorus Compounds; Peptides; Sarin; Soman; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiocholine; Trypsin

2009
Hydroxy oximes as organophosphorus nerve agent sensors.
    Angewandte Chemie (International ed. in English), 2009, Volume: 48, Issue:42

    Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Organophosphates; Organophosphorus Compounds; Oximes; Sarin; Soman

2009
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
    Chemical communications (Cambridge, England), 2011, May-14, Volume: 47, Issue:18

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Molecular Structure; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridines; Pyridinium Compounds; Soman

2011
Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.
    Toxicology letters, 2011, Sep-25, Volume: 206, Issue:1

    Topics: Animals; Cell Line, Tumor; Chemical Warfare Agents; Diaphragm; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ion Channel Gating; Male; Muscle Contraction; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Poisoning; Pyridinium Compounds; Sarin; Soman

2011
A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning.
    Acta biochimica Polonica, 2011, Volume: 58, Issue:2

    Topics: Acetylcholinesterase; Adult; Animals; Antidotes; Atropine Derivatives; Cell Death; Cell Survival; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Assays; Erythrocytes; Humans; Lymphocytes; Male; Mice; Organophosphate Poisoning; Organophosphates; Paraoxon; Pralidoxime Compounds; Soman

2011
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
    Toxicology letters, 2011, Sep-25, Volume: 206, Issue:1

    Topics: Acetylcholinesterase; Aged; Chemical Warfare Agents; Cholinesterase Reactivators; Electric Stimulation; Humans; In Vitro Techniques; Intercostal Muscles; Muscle Strength; Neuromuscular Junction; Organophosphates; Oximes; Pyridinium Compounds; Sarin; Soman

2011
Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Animals; Antidotes; Aryldialkylphosphatase; Chemical Warfare Agents; Chlorpyrifos; Guinea Pigs; Humans; Male; Mice; Moths; Organophosphates; Organophosphorus Compounds; Pesticides; Recombinant Proteins; Sarin; Soman

2013
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Amino Acid Substitution; Antidotes; Aryldialkylphosphatase; Catalytic Domain; Chemical Warfare Agents; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman; Substrate Specificity

2013
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman

2013
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: Aryldialkylphosphatase; Aurintricarboxylic Acid; Butyrylcholinesterase; Calcium; Chemical Warfare Agents; Cholinesterase Inhibitors; Edetic Acid; Freezing; Half-Life; Humans; Inactivation, Metabolic; Organophosphates; Organophosphorus Compounds; Plasma; Sarin; Soman

2014
Organophosphorus pesticide and ester analysis by using comprehensive two-dimensional gas chromatography with flame photometric detection.
    Journal of hazardous materials, 2013, Dec-15, Volume: 263 Pt 2

    Topics: Calibration; Chemical Warfare; Chromatography, Gas; Gasoline; Hydrocarbons; Kerosene; Limit of Detection; Organophosphates; Organophosphorus Compounds; Pesticides; Phosphorus; Photometry; Sarin; Soil; Soil Pollutants; Soman; Temperature

2013
Detection of nerve agents using proton transfer reaction mass spectrometry with ammonia as reagent gas.
    European journal of mass spectrometry (Chichester, England), 2013, Volume: 19, Issue:3

    Topics: Ammonia; Chemical Warfare Agents; Mass Spectrometry; Models, Chemical; Organophosphates; Organophosphonates; Organophosphorus Compounds; Protons; Sarin; Soman; Water

2013
Selective chromo-fluorogenic detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) with a unique probe based on a boron dipyrromethene (BODIPY) dye.
    Organic & biomolecular chemistry, 2014, Nov-21, Volume: 12, Issue:43

    Topics: Acetonitriles; Boron Compounds; Chemical Warfare Agents; Color; Colorimetry; Humans; Limit of Detection; Membranes, Artificial; Molecular Mimicry; Molecular Probes; Organophosphates; Phosphorylation; Reagent Strips; Sarin; Silica Gel; Solvents; Soman; Substrate Specificity

2014
Chiral separation of G-type chemical warfare nerve agents via analytical supercritical fluid chromatography.
    Chirality, 2014, Volume: 26, Issue:12

    Topics: Chemical Warfare Agents; Chromatography, Supercritical Fluid; Mass Spectrometry; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2014
Identification of chemical warfare agents from vapor samples using a field-portable capillary gas chromatography/membrane-interfaced electron ionization quadrupole mass spectrometry instrument with Tri-Bed concentrator.
    Journal of chromatography. A, 2015, Aug-07, Volume: 1406

    Topics: Chemical Warfare Agents; Chemistry Techniques, Analytical; Gas Chromatography-Mass Spectrometry; Gases; Mechlorethamine; Mustard Gas; Organophosphates; Sarin; Soman

2015
Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis.
    Journal of chromatography. A, 2015, Sep-04, Volume: 1410

    Topics: Adsorption; Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Phenols; Polymers; Sarin; Soman; Volatilization

2015
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
    Neurotoxicology, 2015, Volume: 50

    Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman

2015
Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase.
    Combinatorial chemistry & high throughput screening, 2016, Volume: 19, Issue:4

    Topics: Aluminum; Catalytic Domain; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Metals; Molecular Docking Simulation; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman; Stereoisomerism

2016
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
    Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B

    Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Half-Life; Humans; Kinetics; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Oximes; Phenols; Pralidoxime Compounds; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship

2016
A Rapid and Sensitive Strip-Based Quick Test for Nerve Agents Tabun, Sarin, and Soman Using BODIPY-Modified Silica Materials.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Aug-01, Volume: 22, Issue:32

    Topics: Boron Compounds; Chemical Warfare Agents; Nerve Agents; Organophosphates; Prothrombin Time; Sarin; Silicon Dioxide; Soman

2016
Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:4

    Topics: Animals; Antidotes; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Humans; Lethal Dose 50; Male; Mice; Nerve Agents; Nicotinic Agonists; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman; Treatment Outcome

2018
Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication.
    International journal of molecular sciences, 2018, Apr-23, Volume: 19, Issue:4

    Topics: Biodegradation, Environmental; Chemical Warfare Agents; Organophosphates; Organophosphorus Compounds; Phosphoric Triester Hydrolases; Principal Component Analysis; Soman

2018
"Covalent-Assembly"-Based Fluorescent Probe for Detection of a Nerve-Agent Mimic (DCP) via Lossen Rearrangement.
    Analytical chemistry, 2019, 09-03, Volume: 91, Issue:17

    Topics: Aniline Compounds; Biphenyl Compounds; Chemical Warfare Agents; Fluorescent Dyes; Humans; Isocyanates; Kinetics; Limit of Detection; Molecular Mimicry; Organophosphates; Organophosphorus Compounds; Phenanthridines; Sarin; Soman; Spectrometry, Fluorescence

2019
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
    Toxicology mechanisms and methods, 2020, Volume: 30, Issue:9

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors

2020
Improving Quantification of tabun, sarin, soman, cyclosarin, and sulfur mustard by focusing agents: A field portable gas chromatography-mass spectrometry study.
    Journal of chromatography. A, 2021, Jan-11, Volume: 1636

    Topics: Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organophosphorus Compounds; Reference Standards; Sarin; Soman

2021