soman has been researched along with sarin in 231 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (29.44) | 18.7374 |
| 1990's | 47 (20.35) | 18.2507 |
| 2000's | 49 (21.21) | 29.6817 |
| 2010's | 58 (25.11) | 24.3611 |
| 2020's | 9 (3.90) | 2.80 |
| Authors | Studies |
|---|---|
| Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A | 1 |
| Gordon, JJ; Leadbeater, L | 1 |
| Hauser, W; Weger, N | 1 |
| Brimblecombe, RW; French, MC; Webb, SN | 1 |
| Bosković, B | 1 |
| Lanks, KW; Lieske, CN; Papirmeister, B | 1 |
| Broomfield, CA; Harris, LW; Heyl, WC; Stitcher, DL | 1 |
| Adams, GK; O'Leary, JF; Yamamura, HI | 1 |
| Bajgar, J | 3 |
| Anderson, DR; Harris, LW; Lennox, WJ; Murrow, ML; Solana, RP; Wade, JV | 1 |
| Dettbarn, WD; Gupta, RC | 1 |
| Boulet, CA; Clement, JG; Hansen, AS | 1 |
| Maxwell, DM | 1 |
| Fiekers, JF; Heppner, TJ | 1 |
| Freeman, SE; Lau, WM; Szilagyi, M | 2 |
| Bokonjić, D; Rosić, N | 1 |
| Bessette, E; Clement, JG; Erhardt, N; Rosario, S | 1 |
| Rosenberg, P; Schupper, H | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG | 1 |
| Broomfield, CA; Castro, CA; Finger, AV; Lenz, DE; Maxwell, DM; Solana, RP | 1 |
| Bide, RW; Parker, D; Sawyer, TW; Thomas, N; Weiss, MT | 1 |
| Baraka, A | 1 |
| Crain, R; Rosenberg, P; Supernovich, C | 1 |
| Naseem, SM | 1 |
| Eldefrawi, AT; Eldefrawi, ME; Silveira, CL | 1 |
| Anzueto, A; deLemos, RA; Hamil, H; Jenkinson, SG; Johnson, D; Moore, G; Seidenfeld, J | 1 |
| Nieminen, SA; Sirkka, U; Ylitalo, P | 1 |
| Heikkinen, O; Lecklin, A; Nieminen, SA; Ylitalo, P | 1 |
| Dewey, WL; Tripathi, HL | 1 |
| Goldstein, BD | 1 |
| Shih, TM; Whalley, CE | 1 |
| Bucci, TJ; Crowell, JA; Dacre, JC; Parker, RM | 1 |
| Jokanović, M | 2 |
| Ho, IK; Hoskins, B; Liu, DD | 1 |
| Ho, IK; Hoskins, B; Liu, DD; Watanabe, HK | 1 |
| Boucher, LJ; Broomfield, CA; Fox-Talbot, MK; Lenz, DE; Little, JS; MacIver, B | 1 |
| Chou, TC; Sun, MC; Zhang, H | 1 |
| Drewes, LR; Singh, AK; Zeleznikar, RJ | 1 |
| Drewes, LR; Singh, AK | 1 |
| Chang, TC; Dretchen, KL; Gray, AP; Henderson, TR; Platz, RD; Takahashi, K | 1 |
| Dacre, JC; Goldman, M; Klein, AK; Nasr, ML | 1 |
| Pantelić, D | 1 |
| Haraldsson, S; Lundberg, S; Marchner, H | 1 |
| Artursson, E; Bucht, G; Puu, G | 1 |
| Andersen, RA; Fonnum, F; Malthe-Sørenssen, D; Odden, E | 1 |
| Désiré, B; Saint-André, S | 2 |
| Sipponen, KB | 1 |
| Graham, JS; Jaax, NK; McLeod, CG; Singer, AW | 1 |
| Goldman, M; Klein, AK; Nasr, ML | 1 |
| Dawson, RM; Gray, PJ | 1 |
| Fincher, DR; Goldstein, BD; Searle, JR | 1 |
| Fernando, JC; Ho, IK; Hoskins, B | 1 |
| Dulaney, MD; Fernando, JC; Ho, IK; Hoskins, B; Lim, DK; Liu, DD; Watanabe, HK | 1 |
| Beers, ET; Glenn, JF; Rickett, DL | 1 |
| Lynch, MR; Rice, MA; Robinson, SE | 1 |
| Flynn, CJ; Wecker, L | 1 |
| Chou, TC; Li, FZ; Sun, MC | 1 |
| Albuquerque, EX; Boyne, AF; Deshpande, SS; Meshul, CK | 1 |
| Fernando, JC; Ho, IK; Hoskins, B; Lim, DK | 1 |
| Green, MD; Kaminskis, A; Reid, F | 1 |
| Berman, HA; Edery, H | 1 |
| Alberts, P; Ogren, VR | 1 |
| Dulaney, MD; Ho, IK; Hoskins, B | 1 |
| Inns, RH; Leadbeater, L; Rylands, JM | 1 |
| Bruckert, HJ; Franzes, N; Hochrainer, D; Krügel, M; Oldiges, H; Schoene, K | 1 |
| Winbladh, B | 1 |
| Heath, C; Preston, E | 1 |
| Angelov, A | 1 |
| Sidell, FR | 1 |
| Liu, CH; Pei, SQ; Wang, ZX; Zhao, DL | 1 |
| Van der Wiel, HJ; Vanwersch, RA; Wolthuis, O | 1 |
| Ellin, RI; Shih, ML | 1 |
| Ho, IK; Hoskins, B; Sivam, SP | 1 |
| Harvey, B; Sellers, DJ; Watts, P | 1 |
| Beck, HC; Benschop, HP; Van den Berg, GR | 1 |
| Binenfeld, Z; Maksimović, M; Markov, V | 1 |
| Frew, R; Lundy, PM | 1 |
| Clement, JG; Copeman, HT | 1 |
| Hopff, WH; Riggio, G; Waser, PG | 1 |
| Lundy, PM; Shih, TM | 1 |
| Clement, JG; Filbert, M | 1 |
| Clement, JG | 1 |
| Ellin, RI; Groff, WA; Kaminskis, A | 1 |
| Sterri, SH | 1 |
| Alkalay, D; Cohen, G; Kadar, T; Raveh, L; Sahar, R; Shapira, S | 1 |
| Hänninen, O; Kaliste-Korhonen, E; Raushel, FM; Tuovinen, K | 2 |
| Smith, AP | 1 |
| Blank, JA; Fricke, RF; Hobson, DW; Koplovitz, I; Olson, CT; Rockwood, GA; Scharf, BA | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Ashani, Y; Asher, JM; Brecht, KM; Caranto, GR; Larrison, RW; Maxwell, DM; Raveh, L; Schutz, MB; Waibel, KH; Wolfe, AD | 1 |
| Ashani, Y; Cohen, E; Grunwald, J; Marcus, D; Papier, Y; Raveh, L | 1 |
| Jokanović, M; Kosanović, M; Maksimović, M | 1 |
| Degenhardt-Langelaan, CE; Kientz, CE | 1 |
| Broomfield, CA; Davies, HG; Furlong, CE; Keifer, M; Richter, RJ; Sowalla, J | 1 |
| La Du, BN | 1 |
| Bajgar, J; Kassa, J | 1 |
| Belkin, M; Solberg, Y | 1 |
| Ianno, LV; Musiĭchuk, IuI | 1 |
| Holstege, CP; Kirk, M; Sidell, FR | 1 |
| Becker, G; Kawan, A; Szinicz, L | 1 |
| Iwase, H; Kobayashi, M; Matsuda, Y; Nagao, M; Nakajima, M; Niijima, H; Takatori, T | 1 |
| Black, RM; Harrison, JM; Read, RW | 1 |
| Barak, D; Greenblatt, HM; Harel, M; Kryger, G; Millard, CB; Ordentlich, A; Raves, ML; Segall, Y; Shafferman, A; Silman, I; Sussman, JL | 1 |
| Broomfield, CA; Lockridge, O; Millard, CB | 1 |
| Cheng, TC; DeFrank, JJ; Rastogi, VK | 1 |
| Maxwell, DM; Sweeney, RE | 1 |
| Broomfield, CA; Platteborze, PL | 1 |
| Popov, BN; Xie, Y | 1 |
| McDonough, JH; Shih, TM | 1 |
| Isobe, I; Iwasa, M; Koyama, H; Maeno, Y; Nagao, M; Nakajima, M; Niijima, H; Takatori, T | 1 |
| Barcza, T; Cheng, TC; DeFrank, JJ; Hong, K; Jaing, J; Jaszberenyi, JC; Madec, J; McGuinn, WD; Papahadjopoulos, D; Pei, L; Petrikovics, I; Song, ZH; Sylvester, D; Tamulinas, C; Way, JL; Yin, R | 1 |
| Cheng, TC; DeFrank, JJ; Hill, CM; Li, WS; Raushel, FM | 1 |
| D'Agostino, PA; Hancock, JR; Provost, LR | 1 |
| Hamazaki, T; Kataoka, M; Seto, Y; Takesako, H; Tsuge, K | 1 |
| Chen-Goodspeed, M; Li, WS; Lum, KT; Raushel, FM; Sogorb, MA | 1 |
| Abraham, S; Kadar, T; Oz, N; Sahar, R | 1 |
| Brubaker, KL; Kimmell, TA; O'Neill, HJ; Schneider, JF; Sytsma, LF | 1 |
| Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG | 1 |
| Amundson, DE; Devereaux, A; Lazarus, AA; Parrish, JS | 1 |
| Collins, GE; Mulchandani, A; Pumera, M; Wang, J | 1 |
| Bowditch, AP; Crofts, HS; Muggleton, NG; Pearce, PC; Scott, EA | 1 |
| Klauchek, VV; Skodich, PE; Zhukov, VE | 1 |
| Bueters, TJ; Harrison, PK; Ijzerman, AP; Tattersall, JE; van Helden, HP | 1 |
| Huebner, HJ; Li, Y; Lum, KT; Phillips, TD; Raushel, FM | 1 |
| LOOMIS, TA; SALAFSKY, B | 1 |
| HEILBRONN, E; TOLAGEN, B | 1 |
| Ashani, Y; Pistinner, S | 1 |
| Bajgar, J; Sevelová, L; Vachek, J | 1 |
| Adams, TK; Capacio, BR; Korte, WD; Smith, JR; Whalley, CE | 1 |
| Niven, AS; Roop, SA | 1 |
| Newmark, J | 1 |
| Feng, C; Xie, J | 1 |
| Chenier, CL; D'Agostino, PA; Hancock, JR; Lepage, CR | 1 |
| Seto, Y; Tsuge, K | 1 |
| Cohen, O; Kronman, C; Mazor, O; Ordentlich, A; Raveh, L; Shafferman, A | 1 |
| Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA | 1 |
| Kellar, KJ | 1 |
| Le Guével, E; Moutiers, G; Rodriguez-Dafonte, P; Terrier, F | 1 |
| Bajgar, J; Bartosova, L; Blaha, V; Fusek, J; Hajek, P; Jun, D; Krs, O; Kuca, K; Slizova, D | 1 |
| Gorbunova, ZI; Khodakovskaia, OA; Malochkina, EI; Sheluchenko, VV; Zotova, TA | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Froment, MT; Li, H; Lockridge, O; Masson, P; Nachon, F; Schopfer, LM | 1 |
| Curtin, BF; Dhoieam, P; Doctor, BP; Gordon, RK; Nambiar, MP; Seetharam, KI | 1 |
| Dawson, RM; Kotsonis, SE; Pantelidis, S; Rose, HR | 1 |
| Hrobak, PK | 1 |
| Grigoryan, H; Lockridge, O; Masson, P; Schopfer, LM; Terry, AV; Thompson, CM | 1 |
| Beck, JM; Hadad, CM | 1 |
| Asojo, O; Carlson, JE; Carr, J; Ding, SJ; Hinrichs, SH; Li, B; Li, Y; Lockridge, O; Masson, P; Nachon, F; Schopfer, LM; Thompson, CM; Tong, L; Xue, W | 1 |
| Kanamori-Kataoka, M; Seto, Y | 2 |
| Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Pereira, EF | 1 |
| Bahnson, BJ; Cerasoli, DM; Epstein, TM; Kirby, SD; Samanta, U | 1 |
| Akkerman, M; Albuquerque, EX; Alkondon, M; Aracava, Y; Merchenthaler, I; Pereira, EF | 1 |
| Barakat, NH; Beck, JM; Cashman, JR; Gilley, CB; Hadad, CM; MacDonald, M; Okolotowicz, K; Vyas, S; Zhang, J; Zheng, X | 1 |
| Cashman, JR; Gilley, C; Lockridge, O; MacDonald, M; Nachon, F; Schopfer, LM; Zhang, J | 1 |
| Dale, TJ; Rebek, J | 1 |
| Charova, TA; Frolov, AS | 1 |
| Blum, MM; Gäb, J; Hellweg, T; Kehe, K; Melzer, M; Wellert, S | 1 |
| Halamek, E; Hoskovcova, M; Kobliha, Z | 1 |
| McDonough, JH; O'Donnell, JC; Shih, TM | 1 |
| Blum, MM; Gäb, J; John, H; Melzer, M | 1 |
| Meyerhoff, ME; Meyeroff, ME; Ramanathan, M; Simonian, AL; Wang, L; Wild, JR | 1 |
| Thiermann, H; Wille, T; Worek, F | 2 |
| Blum, MM; Gäb, J; John, H | 1 |
| Ling, EA; Loke, WK; Tang, FR | 1 |
| Alamneh, Y; Biggemann, L; Doctor, BP; Nambiar, MP; Perkins, MW; Rezk, P; Sciuto, AM; Valiyaveettil, M | 1 |
| Alamneh, Y; Doctor, BP; Nambiar, MP; Perkins, MW; Rezk, P; Sciuto, AM; Valiyaveettil, M | 1 |
| Cashman, JR; Kalisiak, J; Ralph, EC; Zhang, J | 1 |
| Acharya, JN; Bhattacharya, BK; RamaRao, G | 1 |
| Kaljurand, M; Kubáň, P; Makarõtševa, N; Seiman, A; Vaher, M | 1 |
| Doctor, BP; Marshall, S; Morthole, V; Nambiar, MP; Oguntayo, S; Perkins, MW; Pierre, Z; Rezk, P; Sciuto, AM; Song, J | 1 |
| Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW | 1 |
| Bird, M; Chad, JE; Green, AC; Price, M; Tattersall, JE; Timperley, CM; Turner, SR | 1 |
| Bumm, R; Friess, H; Gerhardus, J; Langer, P; Mihaljevic, AL; Niessen, KV; Seeger, T; Thiermann, H; Worek, F | 1 |
| Aleixandre, M; Cané, C; Fernández, MJ; Fontecha, J; Gràcia, I; Horrillo, MC; Matatagui, D | 1 |
| Dubey, DK; Kanaujia, PK; Pardasani, D; Purohit, AK; Tak, V | 1 |
| Costero, AM; Gil, S; Gotor, R; Martínez-Máñez, R; Parra, M; Sancenón, F | 1 |
| Gor, GY; Lee, MT; Neimark, AV; Vishnyakov, A | 1 |
| Grunden, AM; Semcer, RL; Shah, SS; Theriot, CM | 1 |
| Bao, Y; Chen, J; Lin, Y; Liu, Q; Wu, B; Xie, J | 1 |
| Creasy, WR; Fry, RA; McGarvey, DJ | 1 |
| Barondeau, DP; Bigley, AN; Fox, N; Harvey, SP; Raushel, FM; Tsai, PC | 1 |
| Collins, JL; Lee, R; Peng, X; Pierre, Z; Sciuto, AM; Witriol, A | 1 |
| Cerasoli, DM; Chilukuri, N; Harrison, J; Hodgins, SM; Kasten, SA; Oliver, ZP; Otto, TC; Reeves, TE; Rezk, P | 1 |
| Bahnson, BJ; Cerasoli, DM; Kirby, SD; Norris, JR; Richard Smith, J | 1 |
| Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R | 1 |
| Bragg, W; Hamelin, EI; Johnson, RC; Shaner, RL; Swaim, LL | 1 |
| Li, D; Li, J; Liu, X; Marriott, PJ; Rose, G | 1 |
| Ringer, JM | 1 |
| Coleman, RM; Crow, BS; Hamelin, EI; Jakubowski, EM; Johnson, RC; Lawrence, RJ; Schulze, ND; Shaner, RL | 1 |
| Chen, J; Feng, J; Guo, L; Li, C; Lin, Y; Liu, Q; Wu, B; Xie, J; Yan, L | 1 |
| Cashman, JR; Dwyer, M; Javor, S; Ryan, DA; Smith, EM; Wang, B; Zhang, J | 1 |
| Barba-Bon, A; Costero, AM; Gil, S; Martínez-Máñez, R; Sancenón, F | 1 |
| Blake, TA; Brewer, BN; Carter, MD; Crenshaw, MD; Crow, BS; Evans, RA; Garton, JW; Johnson, RC; Pantazides, BG; Perez, JW; Quiñones-González, J; Read, RW; Riches, JR; Stubbs, SJ; Thomas, JD; Tomcik, DJ; Watson, CM | 1 |
| Cerasoli, DM; Dephillipo, T; Jones, JL; Kasten, SA; Zulli, S | 1 |
| Ikeda, T; Kondo, T; Kurimata, N; Nagashima, H; Nagoya, T; Seto, Y; Unoke, S | 1 |
| Płusa, T; Sokołowski, R | 1 |
| Caetano, MS; da Cunha, EF; de Castro, AA; Mancini, DT; Ramalho, TC; Rocha, EP; Silva, TC | 1 |
| Cadieux, CL; Cerasoli, D; Koenig, JA; Koh, J; McDonough, J; Shih, TM; Wang, H; Zhang, Y | 1 |
| Biyikal, M; Climent, E; Costero, AM; Dropa, T; Gawlitza, K; Martínez-Máñez, R; Rurack, K; Urban, M | 1 |
| Appel, AS; Logue, BA; McDonough, JH; McMonagle, JD | 1 |
| Ash, T; Banu, T; Das, AK; Debnath, T | 1 |
| Neumaier, K; Seeger, T; Thiermann, H; Wille, T; Worek, F | 1 |
| Anslyn, EV; Phillips, ST; Reuther, JF; Sun, X | 1 |
| Baygildiev, T; Braun, A; Koryagina, N; Rodin, I; Rybalchenko, I; Shpigun, O; Stavrianidi, A; Zatirakha, A | 1 |
| Dagan, S; Elgarisi, M; Madmon, M; Weissberg, A | 2 |
| Bae, SY; Bigley, AN; Harvey, SP; Height, JJ; McMahon, LR; Myslinski, JM; Raushel, FM | 1 |
| Beste, A; Shih, TM; Taylor, DE; Thomas, TP | 1 |
| Andjelkovic, B; Koskela, H; Kuitunen, ML; Pettersson, A; Rapinoja, ML; Vanninen, P | 1 |
| Brown, AA; Coleman, RM; Hamelin, EI; Johnson, RC; Kaplan, P; Perez, J; Platanitis, K; Schulze, N; Seymour, C; Shaner, RL | 1 |
| Alcaraz, A; Hok, S; Leif, RN; Salazar, EP; Valdez, CA; Vu, AK | 1 |
| Bai, X; Du, M; Gong, A; Huo, B; Lai, Y; Li, M; Shen, A; Yang, Y | 1 |
| Escher, B; Job, L; Köhler, A; Skerra, A; Worek, F | 1 |
| Garrett, TJ; Goldberger, BA; Rubin, KM | 1 |
| Bouknight, KD; Compton, JR; Guelta, MA; Harvey, SP; Jurkouich, KM; Khavrutskii, IV; Legler, PM | 1 |
| Chen, J; Gao, R; Guo, L; Lin, Y; Liu, H; Liu, Q; Liu, Y; Lu, X; Wang, H; Wu, J; Xie, J; Xu, B; Zhang, M; Zhang, Y | 1 |
| Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM | 1 |
| Hughes, GT; Kelly, JT; Malloy, TA; Piatkowski, T; Qualley, A; Rubenstein, MH | 1 |
| Acon-Chen, C; Loughery, TN; Shih, TM; Whitten, KA | 1 |
| Leif, RN; Valdez, CA | 1 |
| Ahrens, A; Allers, M; Bock, H; Ficks, A; Hitzemann, M; Zimmermann, S | 1 |
12 review(s) available for soman and sarin
| Article | Year |
|---|---|
Chemical warfare--the nerve gases.
Topics: Antidotes; Chemical Warfare Agents; Gas Poisoning; Humans; Organophosphate Poisoning; Organophosphates; Protective Clothing; Sarin; Soman | 1991 |
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission | 1997 |
Chemical warfare. Nerve agent poisoning.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 1997 |
Alteromonas prolidase for organophosphorus G-agent decontamination.
Topics: Aryldialkylphosphatase; Chemical Warfare Agents; Decontamination; Dipeptidases; Esterases; Gram-Negative Aerobic Bacteria; Organophosphates; Organophosphorus Compounds; Sarin; Soman | 1999 |
A review of nerve agent exposure for the critical care physician.
Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 2002 |
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.
Topics: Antidotes; Arsenicals; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Information Services; Internet; Irritants; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Primary Prevention; Protective Clothing; Sarin; Soman | 2002 |
Inhalational exposure to nerve agents.
Topics: Chemical Warfare Agents; Disaster Planning; Humans; Lung Diseases; Lung Injury; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman; United States | 2004 |
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
Comparison of status epilepticus models induced by pilocarpine and nerve agents - a systematic review of the underlying aetiology and adopted therapeutic approaches.
Topics: Animals; Brain; Chemical Warfare Agents; Humans; Pilocarpine; Sarin; Soman; Status Epilepticus | 2011 |
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning.
Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 2011 |
[Today's threat of use of organophosphorus compounds].
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Environmental Exposure; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Seizures; Soman | 2015 |
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
Topics: Alkylation; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methylation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2021 |
1 trial(s) available for soman and sarin
| Article | Year |
|---|---|
Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates.
Topics: Adult; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Cyanosis; Depression; Electrocardiography; Epistaxis; Humans; Insecticides; Male; Mental Disorders; Middle Aged; Placebos; Pralidoxime Compounds; Pyridinium Compounds; Respiration; Sarin; Scopolamine; Soman; Sulfisoxazole; Tachycardia; Time Factors | 1974 |
218 other study(ies) available for soman and sarin
| Article | Year |
|---|---|
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine | 2008 |
The prophylactic use of l-methyl, 2-hydroxyiminomethylpyridinium methanesulfonate (P2S) in the treatment of organophosphate poisoning.
Topics: Animals; Atropine; Drug Therapy, Combination; Female; Guinea Pigs; Lethal Dose 50; Mesylates; Organophosphate Poisoning; Pralidoxime Compounds; Rabbits; Sarin; Soman; Time Factors | 1977 |
Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.
Topics: Animals; Antidotes; Aspartate Aminotransferases; Atropine; Benactyzine; Cholinesterase Inhibitors; Cholinesterases; Creatine Kinase; Dogs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Pyridinium Compounds; Sarin; Soman | 1979 |
Effects of certain muscarinic antagonists on the actions of anticholinesterases on cat skeletal muscle.
Topics: Acetylcholinesterase; Animals; Cats; Cholinesterase Inhibitors; Drug Interactions; Female; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neostigmine; Parasympatholytics; Sarin; Soman | 1979 |
The influence of 2-/o-cresyl/-4 H-1 : 3 : 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cyclic P-Oxides; Drug Interactions; Liver; Male; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sarin; Soman; Structure-Activity Relationship | 1979 |
Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. II. Characterization of the reactivating components.
Topics: Acetylcholinesterase; Animals; Electrophorus; Enzyme Activation; Isoflurophate; Kinetics; Molecular Weight; Organophosphorus Compounds; Phenylacetates; Sarin; Soman | 1977 |
Effects of 1,1'-oxydimethylene bis-(4-tert-butylpyridinium chloride) (SAD-128) and decamethonium on reactivation of soman- and sarin-inhibited cholinesterase by oximes.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Decamethonium Compounds; Drug Interactions; Enzyme Reactivators; Erythrocytes; Humans; In Vitro Techniques; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rabbits; Sarin; Soman | 1978 |
Recovery of central respiratory function following anticholinesterase intoxication.
Topics: Acetylcholinesterase; Animals; Brain Stem; Cholinesterase Inhibitors; Female; Guinea Pigs; Male; Organophosphorus Compounds; Paralysis; Phrenic Nerve; Respiration; Sarin; Soman; Time Factors | 1976 |
Biological monitoring of exposure to nerve agents.
Topics: Acetylcholinesterase; Animals; Brain; Diaphragm; Dogs; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Salivation; Sarin; Seizures; Soman | 1992 |
Successful pretreatment/therapy of soman, sarin and VX intoxication.
Topics: Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Phenylpropionates; Physostigmine; Poisoning; Sarin; Soman; Trihexyphenidyl; Tropanes | 1992 |
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine | 1992 |
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman | 1992 |
The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds.
Topics: Acetylcholinesterase; Animals; Brain; Carboxylic Ester Hydrolases; In Vitro Techniques; Kinetics; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Paraoxon; Rats; Rats, Inbred Strains; Sarin; Soman; Substrate Specificity | 1992 |
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission | 1991 |
The influence of inhibitors and other factors on cholinesterases.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Female; Organophosphorus Compounds; Organothiophosphates; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1991 |
Effects of some organophosphorus compounds on the binding of a radioligand (8-cyclopentyl 1, 3-[3H]dipropylxanthine) to adenosine receptors in ovine cardiac membranes.
Topics: Animals; Cholinesterase Inhibitors; In Vitro Techniques; Myocardium; Organophosphates; Potassium Channels; Receptors, Purinergic; Sarin; Sheep; Soman; Xanthines | 1991 |
Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds.
Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Male; Midazolam; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Soman and sarin inhibition of molecular forms of acetylcholinesterase in mice. Time course of recovery and reactivation by the oxime HI-6.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Hypothalamus; Isoenzymes; Male; Mice; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors | 1991 |
Effects of diisopropyl phosphofluoridate, sarin and soman on the accessibility of proteins, in the electroplax membrane, to lactoperoxidase-catalyzed iodination.
Topics: Animals; Cell Membrane Permeability; Cholinesterases; Electrophoresis, Polyacrylamide Gel; Electrophorus; In Vitro Techniques; Iodine Radioisotopes; Isoflurophate; Lactoperoxidase; Lipid Bilayers; Macromolecular Substances; Membrane Proteins; Molecular Weight; Proteins; Sarin; Soman | 1991 |
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl | 1991 |
Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.
Topics: Animals; Behavior, Animal; Butyrylcholinesterase; Learning; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Poisoning; Sarin; Soman | 1991 |
Efficacy of an oximate-based skin decontaminant against organophosphate nerve agents determined in vivo and in vitro.
Topics: Acetylcholinesterase; Animals; Brain; Chick Embryo; Cholinesterase Inhibitors; Decontamination; Diacetyl; Female; Male; Neurons; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Effect of soman and sarin on phosphatidylcholine asymmetry in the electroplax from the electric eel.
Topics: Animals; Cell Membrane; Cholesterol; Electric Organ; Electrophorus; Kinetics; Lipid Bilayers; Membrane Lipids; Phosphatidylcholines; Sarin; Soman | 1991 |
Effect of organophosphates on dopamine and muscarinic receptor binding in rat brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Female; N-Methylscopolamine; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Sarin; Scopolamine Derivatives; Soman; Spiperone | 1990 |
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
Topics: Animals; Cholinesterase Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Echothiophate Iodide; Insecticides; Male; Myocardium; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sarin; Soman; Tritium | 1990 |
Acute inhalation toxicity of soman and sarin in baboons.
Topics: Administration, Inhalation; Airway Resistance; Animals; Apnea; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bronchoalveolar Lavage Fluid; Diaphragm; Heart Block; Hemodynamics; Hypoxia; Injections, Intravenous; Lung; Neutrophils; Organophosphorus Compounds; Papio; Respiration; Sarin; Soman | 1990 |
Neurobehavioral toxicity with low doses of sarin and soman.
Topics: Animals; Avoidance Learning; Behavior, Animal; Male; Nervous System Diseases; Nociceptors; Organophosphorus Compounds; Postural Balance; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Sarin; Soman | 1990 |
Acute behavioural effects of the organophosphates sarin and soman in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Male; Motor Activity; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1990 |
Comparison of the effects of diisopropylfluorophosphate, sarin, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Isoflurophate; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphates; Organophosphorus Compounds; Sarin; Soman | 1989 |
Changes in spinal cord reflexes following subchronic exposure to soman and sarin.
Topics: Action Potentials; Animals; Cats; Cordotomy; Female; Ganglia, Spinal; Male; Motor Neurons; Neuromuscular Junction; Neurons, Afferent; Organophosphorus Compounds; Quipazine; Reflex, Monosynaptic; Sarin; Soman; Spinal Cord | 1989 |
Effects of soman and sarin on high affinity choline uptake by rat brain synaptosomes.
Topics: Acetylcholinesterase; Animals; Brain; Choline; In Vitro Techniques; Male; Organophosphorus Compounds; Rats; Sarin; Soman; Synaptosomes | 1989 |
Neuropathy target esterase in hens after sarin and soman.
Topics: Animals; Chickens; Dose-Response Relationship, Drug; Esterases; Female; Nervous System Diseases; Organophosphorus Compounds; Sarin; Soman; Tritolyl Phosphates | 1989 |
Role of carboxylesterase in soman, sarin and tabun poisoning in rats.
Topics: Animals; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Hydrogen-Ion Concentration; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Phenobarbital; Rats; Rats, Inbred Strains; Sarin; Soman; Tritolyl Phosphates | 1989 |
Acute effects of soman, sarin, and tabun on microsomal and cytosolic components of the calmodulin system in rat striatum.
Topics: Adenylyl Cyclases; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Calmodulin; Corpus Striatum; Cytosol; Guanylate Cyclase; Microsomes; Organophosphates; Organophosphorus Compounds; Phosphoric Diester Hydrolases; Protein Kinases; Rats; Rats, Inbred Strains; Sarin; Soman | 1986 |
Acute effects of Soman, Sarin, and Tabun on cyclic nucleotide metabolism in rat striatum.
Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Male; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1986 |
Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP).
Topics: Animals; Hydrolases; Hydrolysis; Isoflurophate; Kinetics; Liver; Magnesium; Male; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman; Stereoisomerism | 1989 |
Enzymatic synthesis of sarin and soman.
Topics: Animals; In Vitro Techniques; Organophosphorus Compounds; Phosphoric Monoester Hydrolases; Rabbits; Sarin; Soman | 1985 |
Analysis of soman and sarin in blood utilizing a sensitive gas chromatography-mass spectrometry method.
Topics: Acetylcholinesterase; Blood Proteins; Cholinesterases; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Organophosphorus Compounds; Perchlorates; Protein Binding; Sarin; Soman; Time Factors | 1985 |
Binding of some organophosphorus compounds at adenosine receptors in guinea pig brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cholinesterase Inhibitors; Guinea Pigs; Kinetics; Organophosphates; Organophosphorus Compounds; Receptors, Purinergic; Sarin; Soman | 1988 |
Choline transport and metabolism in soman- or sarin-intoxicated brain.
Topics: Acetylcholine; Animals; Biological Transport; Blood-Brain Barrier; Brain; Choline; Cholinesterase Inhibitors; Dogs; In Vitro Techniques; Organophosphate Poisoning; Organophosphorus Compounds; Sarin; Soman | 1988 |
Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes.
Topics: Acetylcholinesterase; Aging; Animals; Antidotes; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Guinea Pigs; Lethal Dose 50; Mice; Naphthalenes; Naphthylvinylpyridine; Pyridines; Sarin; Soman; Structure-Activity Relationship | 1988 |
SCE induction in Chinese hamster ovary cells (CHO) exposed to G agents.
Topics: Animals; Biotransformation; Cell Line; Cricetinae; Microsomes, Liver; Mutagenicity Tests; Organophosphorus Compounds; Sarin; Sister Chromatid Exchange; Soman | 1988 |
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare].
Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman | 1986 |
[The effect of inhibition and activation of ali-esterase on the acute toxicity of organophosphates in rats].
Topics: Acute Disease; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Enzyme Activation; Organophosphates; Organophosphorus Compounds; Rats; Sarin; Soman; Tritolyl Phosphates | 1986 |
Organophosphorus anticholinesterases do not mediate analgesia through inhibition of enkephalin degradation.
Topics: Acetylcholinesterase; Aminopeptidases; Analgesia; Animals; Brain; Cholinesterase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Leucine; Enkephalins; Isoflurophate; Male; Neprilysin; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman; Synaptosomes | 1986 |
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism | 1986 |
Effects of organophosphates on presynaptic events in the vascularly perfused phrenic nerve-hemidiaphragm preparation from the rat.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Isoflurophate; Male; Muscles; Organophosphorus Compounds; Organothiophosphorus Compounds; Perfusion; Phrenic Nerve; Rats; Rats, Inbred Strains; Sarin; Soman; Synapses | 1987 |
Inactivation of sarin and soman by cyclodextrins in vitro.
Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Dextrins; gamma-Cyclodextrins; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Starch | 1987 |
Detector for organophosphorus compounds in liquid chromatography based on the cholinesterase inhibition reaction.
Topics: Acetylcholinesterase; Air; Animals; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Electrophorus; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Spectrophotometry, Ultraviolet | 1987 |
Cardiomyopathy in Soman and Sarin intoxicated rats.
Topics: Animals; Brain; Heart; Male; Myocardium; Necrosis; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Seizures; Soman | 1987 |
The effects of in vitro exposure to the neurotoxins sarin (GB) and soman (GD) on unscheduled DNA synthesis by rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Dimethyl Sulfoxide; DNA; DNA Damage; DNA Repair; Liver; Male; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1987 |
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman | 1987 |
Electrophysiological changes in the primary sensory neuron following subchronic soman and sarin: alterations in sensory receptor function.
Topics: Animals; Cats; Electric Conductivity; Electrophysiology; Mechanoreceptors; Neurons, Afferent; Organophosphorus Compounds; Proprioception; Sarin; Sensory Receptor Cells; Soman | 1987 |
Hypersensitivity to antimuscarinic agents following brief exposure to Soman and Sarin.
Topics: Animals; Atropine; Atropine Derivatives; Drug Hypersensitivity; Male; Organophosphorus Compounds; Parasympatholytics; Rats; Rats, Inbred Strains; Sarin; Soman; Stereotyped Behavior; Tremor | 1986 |
Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.
Topics: Animals; Cholinesterase Inhibitors; Corpus Striatum; Injections, Subcutaneous; Male; Mastication; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Seizures; Soman; Tremor | 1986 |
Central respiratory effects versus neuromuscular actions of nerve agents.
Topics: Animals; Cats; Cholinesterase Inhibitors; Diaphragm; Female; Male; Neuromuscular Junction; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Respiratory Center; Respiratory Insufficiency; Sarin; Soman | 1986 |
Dissociation of locomotor depression and ChE activity after DFP, soman and sarin.
Topics: Animals; Brain; Brain Mapping; Cholinergic Fibers; Cholinesterases; Corpus Striatum; Isoflurophate; Male; Motor Activity; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1986 |
Elevated choline levels in brain. A non-cholinergic component of organophosphate toxicity.
Topics: Acetylcholinesterase; Animals; Brain; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Isoflurophate; Male; Microwaves; Paraoxon; Rats; Rats, Inbred Strains; Sarin; Soman | 1986 |
Interaction of soman with beta-cyclodextrin.
Topics: Acetylcholinesterase; Animals; beta-Cyclodextrins; Binding Sites; Cholinesterase Inhibitors; Cyclodextrins; Dextrins; Drug Interactions; Electrophorus; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Starch | 1986 |
Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Reactivators; Erythrocytes; Humans; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman | 1986 |
Comparison of the ultrastructural myopathy induced by anticholinesterase agents at the end plates of rat soleus and extensor muscles.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Electrophysiology; Female; Microscopy, Electron; Motor Endplate; Muscular Diseases; Nerve Endings; Neuromuscular Junction; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Sarin; Soman; Time Factors | 1985 |
Variability of neurotoxicity of and lack of tolerance to the anticholinesterases soman and sarin in the rat.
Topics: Animals; Body Temperature; Cholinesterase Inhibitors; Drug Tolerance; Male; Nervous System; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Seizures; Soman; Tremor | 1985 |
Correlation of 2-PAM plasma levels after organophosphate intoxication.
Topics: Animals; Female; Guinea Pigs; Insecticides; Male; Pralidoxime Compounds; Sarin; Soman | 1985 |
Yohimbine antagonism of the vasodepression elicited by organophosphates applied on ventral medulla oblongata.
Topics: Animals; Atropine; Blood Pressure; Cats; Cholinesterase Inhibitors; Electrocardiography; Female; Injections, Intraventricular; Male; Medulla Oblongata; Norepinephrine; Organophosphorus Compounds; Respiration; Sarin; Soman; Yohimbine | 1985 |
Sarin and soman depress [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.
Topics: Acetylcholine; Animals; Electric Stimulation; Guinea Pigs; Ileum; Myenteric Plexus; Organophosphorus Compounds; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Soman | 1985 |
Studies on low dose sub-acute administration of soman, sarin and tabun in the rat.
Topics: Acetylcholinesterase; Animals; Body Weight; Brain; Cholinesterase Inhibitors; Growth; Insecticides; Male; Organophosphates; Rats; Rats, Inbred Strains; Sarin; Soman; Time Factors | 1985 |
Treatment of poisoning by soman.
Topics: Animals; Antidotes; Atropine; Carbamates; Diazepam; Guinea Pigs; Male; Motor Activity; Organophosphate Poisoning; Parasympatholytics; Phenylpropionates; Physostigmine; Pyridostigmine Bromide; Sarin; Soman; Time Factors | 1985 |
The protective effect of oxime pretreatment upon the inhalative toxicity of sarin and soman in rats.
Topics: Aerosols; Animals; Organophosphorus Compounds; Oximes; Rats; Rats, Inbred Strains; Sarin; Soman; Time Factors | 1985 |
Choroid plexus uptake of acetylcholine.
Topics: Acetylcholine; Albumins; Animals; Biological Transport, Active; Choline; Cholinesterases; Choroid Plexus; Culture Techniques; Depression, Chemical; Iodine Radioisotopes; Methods; Physostigmine; Rabbits; Salicylates; Sarin; Soman; Stimulation, Chemical; Sulfates; Time Factors; Tritium | 1974 |
Atropine-insensitive vasodilatation and hypotension in the organophosphate-poisoned rabbit.
Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Cholinesterase Inhibitors; Forelimb; Heart Rate; Hypotension; Isoflurophate; Organophosphate Poisoning; Rabbits; Respiration, Artificial; Sarin; Soman; Vascular Resistance; Vasodilator Agents | 1972 |
[The effect of streptomycin on neuromuscular conductivity in cats treated with several phosphoorganic cholinesterase inhibitors].
Topics: Animals; Cats; Cholinesterase Inhibitors; Female; Male; Neuromuscular Junction; Organophosphorus Compounds; Sarin; Soman; Streptomycin | 1973 |
[Effect of soman, sarin and VX on specific binding of 3H-quinuclidinyl benzilate in rat cerebral cortex homogenates].
Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; In Vitro Techniques; Male; Organophosphorus Compounds; Organothiophosphorus Compounds; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Sarin; Soman; Tritium | 1983 |
The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man.
Topics: Adult; Aged; Animals; Antidotes; Chorionic Gonadotropin; Dogs; Electric Stimulation; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman; Species Specificity; Synaptic Transmission | 1981 |
Stability of aqueous solutions of sarin and soman: influence of concentration and an equation for determining concentration.
Topics: Chemical Phenomena; Chemistry; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Sarin; Solutions; Soman | 1984 |
An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Corpus Striatum; Erythrocytes; gamma-Aminobutyric Acid; In Vitro Techniques; Isoflurophate; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Parasympathetic Nervous System; Rats; Rats, Inbred Strains; Sarin; Soman | 1984 |
The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents.
Topics: Cholinesterase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism | 1984 |
[Direct reactions of pyridinium oximes with organophosphorus compounds].
Topics: Chemical Phenomena; Chemical Warfare Agents; Chemistry; Drug Interactions; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Evidence of reduced uptake of convulsant in brain following prostaglandin E2.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Dinoprostone; Injections, Intraventricular; Male; Mice; Organophosphorus Compounds; Prostaglandins E; Sarin; Soman | 1984 |
Soman and sarin induce a long-lasting naloxone-reversible analgesia in mice.
Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Hot Temperature; Male; Mice; Naloxone; Organophosphorus Compounds; Reaction Time; Sarin; Soman | 1984 |
Blockade of acetylcholine synthesis in organophosphate poisoning.
Topics: Acetylcholine; Animals; Drug Interactions; Female; Lethal Dose 50; Male; Methyl Methanesulfonate; Mice; Organophosphorus Compounds; Rats; Sarin; Soman; Time Factors | 1984 |
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Injections, Intraventricular; Lethal Dose 50; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1983 |
Antidote effect of sodium fluoride against organophosphate poisoning in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Drug Interactions; Fluorides; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Sarin; Sodium Fluoride; Soman | 1983 |
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nerves; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1982 |
The stability of sarin and soman in dilute aqueous solutions and the catalytic effect of acetate ion.
Topics: Acetates; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Organophosphorus Compounds; Sarin; Solutions; Soman; Temperature | 1981 |
Factors modifying the toxicity of organophosphorus compounds including dichlorvos.
Topics: Acetylcholinesterase; Animals; Cholinesterases; Dichlorvos; Enzyme Activation; Esterases; Guinea Pigs; Insecticides; Lethal Dose 50; Mice; Rats; Sarin; Soman | 1981 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
Sarin-induced neuropathology in rats.
Topics: Animals; Brain; Brain Diseases; Male; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Soman | 1995 |
Phosphotriesterase--a promising candidate for use in detoxification of organophosphates.
Topics: Adult; Animals; Aryldialkylphosphatase; Brain; Cholinesterase Reactivators; Cholinesterases; Esterases; Female; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred Strains; Middle Aged; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Sarin; Soman | 1994 |
Long-term effects of the anticholinesterases sarin and soman on latencies of muscle action potentials in mouse diaphragm muscle.
Topics: Action Potentials; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Erythrocytes; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Muscles; Sarin; Soman | 1993 |
Efficacy of tacrine as a nerve agent pretreatment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Chemical Warfare Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Mice; Organophosphates; Sarin; Soman; Tacrine | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Inactivation, Metabolic; Lethal Dose 50; Mice; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 1994 |
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
Topics: Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Neutralization Tests; Organophosphates; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman | 1993 |
Interaction of organophosphorus compounds with carboxylesterases in the rat.
Topics: Animals; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Enzyme Reactivators; In Vitro Techniques; Inactivation, Metabolic; Kinetics; Liver; Male; Rats; Rats, Wistar; Sarin; Soman | 1996 |
Protection of organophosphate-inactivated esterases with phosphotriesterase.
Topics: Animals; Aryldialkylphosphatase; Biological Availability; Brain; Cholinesterase Inhibitors; Drug Antagonism; Esterases; Isoflurophate; Lung; Male; Mice; Sarin; Soman; Time Factors | 1996 |
Capillary gas chromatographic analysis of nerve agents using large volume injections.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, Gas; Hydrogen-Ion Concentration; Isoflurophate; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Water | 1996 |
The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin.
Topics: Aryldialkylphosphatase; Chemical Warfare Agents; Drug Resistance; Esterases; Homozygote; Humans; Isoenzymes; Organophosphorus Compounds; Polymorphism, Genetic; Sarin; Soman; South America | 1996 |
Structural and functional diversity of paraoxonases.
Topics: Aryldialkylphosphatase; Esterases; Genetic Variation; Organophosphorus Compounds; Sarin; Soman | 1996 |
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 1996 |
Update on Gulf War illness.
Topics: Chemical Warfare Agents; Humans; Persian Gulf Syndrome; Sarin; Soman; Time Factors | 1997 |
[Acute poisoning by neuroparalytic agents and its long-term effects].
Topics: Acute Disease; Adult; Chemical Industry; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Occupational Diseases; Occupations; Organothiophosphorus Compounds; Sarin; Soman; Time Factors | 1997 |
Direct reaction of oximes with sarin, soman, or tabun in vitro.
Topics: Antidotes; Cholinesterase Inhibitors; Half-Life; Organophosphates; Oximes; Sarin; Soman; Spectrophotometry, Ultraviolet | 1997 |
Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Organothiophosphorus Compounds; Rats; Rats, Wistar; Sarin; Soman | 1997 |
Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains.
Topics: Animals; Behavior, Animal; Brain; Chemical Warfare Agents; Enzyme Activation; Male; Organophosphorus Compounds; Phosphorylation; Rats; Rats, Wistar; Sarin; Soman; Type C Phospholipases | 1999 |
The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site.
Topics: Biomarkers; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Protein Binding; Sarin; Serum Albumin; Soman; Tyrosine | 1999 |
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Topics: Acetylcholinesterase; Acetylthiocholine; Acylation; Animals; Binding Sites; Butyrylthiocholine; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Enzyme Activation; Humans; Hydrolysis; Isoflurophate; Kinetics; Models, Molecular; Sarin; Soman; Torpedo | 1999 |
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.
Topics: Animals; Benzoylcholine; Binding Sites; Butyrylcholinesterase; Butyrylthiocholine; Cephamycins; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Design; Echothiophate Iodide; Humans; Hydrolysis; Inactivation, Metabolic; Kinetics; Mutagenesis, Site-Directed; Organophosphates; Organothiophosphorus Compounds; Protein Engineering; Sarin; Soman; Torpedo | 1999 |
A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Esterases; Isoflurophate; Lethal Dose 50; Models, Biological; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1999 |
Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni).
Topics: Animals; Baculoviridae; Butyrylcholinesterase; Cells, Cultured; Cholinesterase Inhibitors; COS Cells; Glycosylation; Humans; Hydrolysis; Larva; Lepidoptera; Organophosphates; Organophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman | 2000 |
Catalyzed hydrolysis of nerve gases by metal chelate compounds and potentiometric detection of the byproducts.
Topics: Catalysis; Chelating Agents; Chemical Warfare Agents; Cholinesterase Inhibitors; Copper; Hydrolysis; Isoflurophate; Potentiometry; Sarin; Soman | 2000 |
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman | 2000 |
The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains.
Topics: Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Coloring Agents; Cytosol; Diphosphonates; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Luminescent Measurements; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Sarin; Soman; Threonine; Tyrosine | 2000 |
Long circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism.
Topics: Animals; Aryldialkylphosphatase; Cholinesterase Inhibitors; Drug Carriers; Esterases; Isoflurophate; Lethal Dose 50; Liposomes; Male; Mice; Mice, Inbred BALB C; Sarin; Soman; Substrate Specificity | 2000 |
Stereochemical specificity of organophosphorus acid anhydrolase toward p-nitrophenyl analogs of soman and sarin.
Topics: Alteromonas; Aryldialkylphosphatase; Catalysis; Escherichia coli; Esterases; Hydrolysis; Sarin; Soman; Stereoisomerism; Substrate Specificity | 2001 |
Determination of sarin, soman and their hydrolysis products in soil by packed capillary liquid chromatography-electrospray mass spectrometry.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Hydrolysis; Reproducibility of Results; Sarin; Soil; Soman; Spectrometry, Mass, Electrospray Ionization | 2001 |
Effect of pedological characteristics on aqueous soil extraction recovery and tert-butyldimethylsilylation yield for gas chromatography-mass spectrometry of nerve gas hydrolysis products from soils.
Topics: Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Hydrolysis; Organophosphates; Organophosphorus Compounds; Organosilicon Compounds; Sarin; Silanes; Soil Pollutants; Soman; Water | 2001 |
Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.
Topics: Aryldialkylphosphatase; Chemical Warfare Agents; Esterases; Hydrolysis; Inactivation, Metabolic; Kinetics; Molecular Conformation; Mutagenesis, Site-Directed; Sarin; Soman | 2001 |
QTc prolongation and cardiac lesions following acute organophosphate poisoning in rats.
Topics: Acute Disease; Animals; Body Weight; Chemical Warfare Agents; Cholinesterase Inhibitors; Electrocardiography; Heart Diseases; Long QT Syndrome; Myocardium; Organophosphate Poisoning; Rats; Rats, Sprague-Dawley; Sarin; Soman | 2001 |
Development of an analytical methodology for sarin (GB) and soman (GD) in various military-related wastes.
Topics: Calibration; Chemical Warfare Agents; Reference Standards; Reproducibility of Results; Sarin; Sensitivity and Specificity; Soman | 2002 |
Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector.
Topics: Chemical Warfare Agents; Electric Conductivity; Electrophoresis; Microchemistry; Miniaturization; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Soman | 2002 |
Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus).
Topics: Animals; Behavior, Animal; Callithrix; Cholinesterase Inhibitors; Discrimination Learning; Drug Implants; Drug Interactions; Female; Male; Muscarinic Antagonists; Organophosphorus Compounds; Physostigmine; Reversal Learning; Sarin; Scopolamine; Serial Learning; Soman | 2003 |
[Scientific principles of sanitary and hygienic basis of chemical weapons demolishment].
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Conservation of Natural Resources; Environmental Exposure; Environmental Monitoring; Humans; Hygiene; Russia; Sanitation; Sarin; Soman | 2002 |
Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Deoxyadenosines; Guinea Pigs; Hippocampus; Male; Microelectrodes; Neurons; Receptor, Adenosine A1; Sarin; Seizures; Soman; Structure-Activity Relationship; Xanthines | 2003 |
Organophosphate nerve agent toxicity in Hydra attenuata.
Topics: Administration, Oral; Animals; Artemia; Biological Assay; Chemical Warfare Agents; Hydra; Models, Molecular; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism; Structure-Activity Relationship; Time Factors; Toxicity Tests | 2003 |
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.
Topics: Atropine; Cholinesterase Inhibitors; Enzyme Inhibitors; Mice; Neostigmine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pharmacology; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Rats; Research; Sarin; Soman; Toxicology | 1963 |
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology | 1965 |
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Erythrocytes; Esterases; Humans; In Vitro Techniques; Inactivation, Metabolic; Models, Biological; Nervous System Diseases; Neuroprotective Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman | 2004 |
Inhalation apparatus for generating sarin and soman toxic vapors.
Topics: Administration, Inhalation; Aerosols; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Sarin; Soman; Toxicology | 2003 |
The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Fluorides; Guinea Pigs; Humans; Kidney; Lethal Dose 50; Macaca mulatta; Sarin; Soman | 2004 |
[Determination of five nerve agents in contaminated serum by gas chromatography].
Topics: Chemical Warfare Agents; Chromatography, Gas; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Serum; Soman | 2005 |
Liquid chromatography electrospray tandem mass spectrometric and desorption electrospray ionization tandem mass spectrometric analysis of chemical warfare agents in office media typically collected during a forensic investigation.
Topics: Central Nervous System Agents; Chemical Warfare Agents; Chromatography, Liquid; Forensic Medicine; Organophosphates; Organophosphorus Compounds; Reproducibility of Results; Sarin; Sensitivity and Specificity; Soman; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2006 |
Detection of human butyrylcholinesterase-nerve gas adducts by liquid chromatography-mass spectrometric analysis after in gel chymotryptic digestion.
Topics: Amino Acid Sequence; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Molecular Structure; Organothiophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization | 2006 |
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Topics: Acetylcholinesterase; Animals; Binding Sites; Butyrylcholinesterase; Humans; Lethal Dose 50; Male; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Polyethylene Glycols; Recombinant Proteins; Sarin; Soman; Survival Analysis; Tissue Distribution | 2006 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors | 2006 |
Overcoming inhibitions.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors | 2006 |
Revisiting the reactivity of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of sarin, soman and DFP under mild conditions.
Topics: Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Organophosphonates; Organophosphorus Compounds; Oximes; Phenols; Sarin; Soman | 2006 |
Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study.
Topics: Acetylcholinesterase; Animals; Apoptosis; Basal Ganglia; Chemical Warfare Agents; Cholinesterase Inhibitors; Female; Frontal Lobe; Rats; Rats, Wistar; Sarin; Soman | 2007 |
[Studying chronic effects caused by alkaline products of from bituminous-salt masses obtained through destruction of sarin, soman and RVX].
Topics: Animals; Chemical Warfare Agents; Hazardous Waste; Hydrocarbons; Male; Organothiophosphates; Rats; Rats, Wistar; Salts; Sarin; Soman; Water | 2006 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.
Topics: Butyrylcholinesterase; Catalytic Domain; Chemical Warfare Agents; Cholinesterase Inhibitors; Deuterium Oxide; Dichlorvos; Echothiophate Iodide; Enzyme Stability; Humans; Insecticides; Isoflurophate; Malathion; Molecular Structure; Peptide Mapping; Sarin; Serine; Soman; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin | 2007 |
Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryldialkylphosphatase; Butyrylcholinesterase; Cell Line; Chemical Warfare Agents; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Mice; Resveratrol; Sarin; Soman; Stilbenes | 2008 |
Degradation of nerve agents by an organophosphate-degrading agent (OpdA).
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Organophosphates; Organophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman | 2008 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.
Topics: Binding Sites; Biotin; Chlorpyrifos; Cholinesterase Inhibitors; Isoflurophate; Organophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tubulin; Tyrosine | 2008 |
Hydrolysis of nerve agents by model nucleophiles: a computational study.
Topics: Chemical Warfare Agents; Hydrolysis; Organothiophosphorus Compounds; Sarin; Soman | 2008 |
Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Topics: Albumins; Biotin; Chlorpyrifos; Chromatography, Liquid; Crystallography, X-Ray; Dichlorvos; Humans; Hydrogen-Ion Concentration; Isoflurophate; Models, Molecular; Molecular Structure; Organophosphorus Compounds; Reproducibility of Results; Sarin; Serine; Soman; Staining and Labeling; Tandem Mass Spectrometry; Tyrosine | 2008 |
Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R).
Topics: Aryldialkylphosphatase; Electrophoresis, Capillary; Genotype; Humans; Hydrolysis; Molecular Structure; Open Reading Frames; Organothiophosphorus Compounds; Polymerase Chain Reaction; Polymorphism, Genetic; Sarin; Soman | 2009 |
Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition.
Topics: Acetylcholinesterase; Age Factors; Animals; Animals, Newborn; Cholinesterase Inhibitors; Female; Guinea Pigs; Male; Organophosphorus Compounds; Sarin; Sex Characteristics; Soman | 2009 |
Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetylcholinesterase; Animals; Brain; Cattle; Chemical Warfare Agents; Crystallography, X-Ray; Dealkylation; Humans; Insecticides; Paraoxon; Sarin; Soman; Synapses | 2009 |
Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Female; Galantamine; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Nerve Degeneration; Organ Culture Techniques; Organophosphate Poisoning; Organophosphorus Compounds; Sarin; Soman; Treatment Outcome | 2010 |
Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Computer Simulation; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Sarin; Soman; Stereoisomerism | 2009 |
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
Topics: Amino Acid Sequence; Butyrylcholinesterase; Catalytic Domain; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Molecular Sequence Data; Organophosphates; Organophosphorus Compounds; Peptides; Sarin; Soman; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiocholine; Trypsin | 2009 |
Hydroxy oximes as organophosphorus nerve agent sensors.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Organophosphates; Organophosphorus Compounds; Oximes; Sarin; Soman | 2009 |
[Cardio-vascular diseases in individuals having long-term effects of acute sarin and soman poisonings].
Topics: Acute Disease; Cardiovascular Diseases; Chemical Industry; Chemical Warfare Agents; Cholinesterase Inhibitors; Data Interpretation, Statistical; Electrocardiography; Female; Follow-Up Studies; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Myocardial Ischemia; Neurocirculatory Asthenia; Occupational Diseases; Sarin; Soman; Time Factors | 2009 |
Monitoring the hydrolysis of toxic organophosphonate nerve agents in aqueous buffer and in bicontinuous microemulsions by use of diisopropyl fluorophosphatase (DFPase) with (1)H- (31)P HSQC NMR spectroscopy.
Topics: Animals; Biosensing Techniques; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Hydrolysis; Limit of Detection; Loligo; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman | 2010 |
Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman.
Topics: Acetylcholinesterase; Biosensing Techniques; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzymes, Immobilized; Isomerism; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Soman | 2009 |
Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs.
Topics: Acetylcholine; Animals; Brain; Chemical Warfare Agents; Choline; Cholinesterase Inhibitors; Corpus Striatum; Electroencephalography; Guinea Pigs; Male; Organothiophosphorus Compounds; Sarin; Seizures; Soman | 2010 |
Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds--characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Chemical; Organophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tromethamine | 2010 |
Monitoring of diisopropyl fluorophosphate hydrolysis by fluoride-selective polymeric films using absorbance spectroscopy.
Topics: Absorption; Biocatalysis; Chemical Warfare Agents; Fluorides; Hydrolysis; Isoflurophate; Phosphoric Monoester Hydrolases; Polymers; Sarin; Soman; Spectrophotometry, Ultraviolet | 2010 |
Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes.
Topics: Acetylcholinesterase; Buffers; Cholinesterase Inhibitors; Drug Interactions; Erythrocytes; Humans; Kinetics; Organophosphates; Oximes; Paraoxon; Sarin; Soman | 2011 |
Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer: implications for analytical and toxicological investigations.
Topics: Buffers; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Diphosphates; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Organophosphorus Compounds; Phosphates; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization | 2011 |
Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs.
Topics: Animals; Aryldialkylphosphatase; Blood Gas Analysis; Blood Pressure; Catalytic Domain; Free Radical Scavengers; Guinea Pigs; Humans; Male; Protective Agents; Rabbits; Sarin; Soman | 2011 |
Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs.
Topics: Acute Lung Injury; Animals; Aryldialkylphosphatase; Brain; Chemical Warfare Agents; Cholinesterases; Guinea Pigs; Humans; Inhalation Exposure; Injections, Intravenous; Instillation, Drug; Kaplan-Meier Estimate; Longevity; Male; Neuroprotective Agents; Oxygen; Rabbits; Recombinant Proteins; Sarin; Soman | 2011 |
Amidine-oximes: reactivators for organophosphate exposure.
Topics: Acetylcholinesterase; Amidines; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Enzyme Reactivators; Female; Humans; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Permeability; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship | 2011 |
Changes of protein oxidation, calpain and cytoskeletal proteins (alpha tubulin and pNF-H) levels in rat brain after nerve agent poisoning.
Topics: Animals; Brain Chemistry; Calpain; Chemical Warfare Agents; Cholinesterases; Female; Neurofilament Proteins; Oxidation-Reduction; Phosphorylation; Proteins; Rats; Rats, Wistar; Sarin; Soman; Tubulin | 2011 |
In situ determination of nerve agents in various matrices by portable capillary electropherograph with contactless conductivity detection.
Topics: Chemical Warfare Agents; Chromatography, High Pressure Liquid; Drug Stability; Electric Conductivity; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry; Linear Models; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Sensitivity and Specificity; Soil; Soman; Specimen Handling | 2011 |
Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs.
Topics: Acetylcholinesterase; Administration, Inhalation; Animals; Atropine; Body Weight; Bronchoalveolar Lavage Fluid; Butyrylcholinesterase; Chemical Warfare Agents; Guinea Pigs; Heart Rate; Inhalation Exposure; Lethal Dose 50; Lung; Male; Plethysmography, Whole Body; Respiratory Tract Diseases; Sarin; Soman; Tidal Volume; Trachea | 2011 |
Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.
Topics: Animals; Cell Line, Tumor; Chemical Warfare Agents; Diaphragm; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ion Channel Gating; Male; Muscle Contraction; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Poisoning; Pyridinium Compounds; Sarin; Soman | 2011 |
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
Topics: Acetylcholinesterase; Aged; Chemical Warfare Agents; Cholinesterase Reactivators; Electric Stimulation; Humans; In Vitro Techniques; Intercostal Muscles; Muscle Strength; Neuromuscular Junction; Organophosphates; Oximes; Pyridinium Compounds; Sarin; Soman | 2011 |
Array of Love-wave sensors based on quartz/Novolac to detect CWA simulants.
Topics: Acetone; Acoustics; Biosensing Techniques; Chemical Warfare Agents; Ethanol; Ethylene Dichlorides; Hexanes; Humans; Mechlorethamine; Methylene Chloride; Organophosphorus Compounds; Phosgene; Polymers; Principal Component Analysis; Propylene Glycols; Quartz; Reproducibility of Results; Sarin; Solvents; Soman | 2011 |
Selective enrichment of the degradation products of organophosphorus nerve agents by zirconia based solid-phase extraction.
Topics: Adsorption; Chemical Warfare Agents; Neurotransmitter Agents; Organophosphorus Compounds; Sarin; Sensitivity and Specificity; Solid Phase Extraction; Soman; Zirconium | 2011 |
A molecular probe for the highly selective chromogenic detection of DFP, a mimic of Sarin and Soman nerve agents.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Chromogenic Compounds; Isoflurophate; Molecular Probes; Molecular Structure; Sarin; Soman | 2011 |
Interactions of phosphororganic agents with water and components of polyelectrolyte membranes.
Topics: Electrolytes; Hydrogen Bonding; Isoflurophate; Lipid Bilayers; Models, Chemical; Organophosphorus Compounds; Polystyrenes; Sarin; Solvents; Soman; Thermodynamics; Water | 2011 |
Improving the catalytic activity of hyperthermophilic Pyrococcus horikoshii prolidase for detoxification of organophosphorus nerve agents over a broad range of temperatures.
Topics: Biotransformation; Chemical Warfare Agents; Dipeptidases; Enzyme Stability; Hydrogen-Ion Concentration; Mutant Proteins; Mutation; Organophosphates; Pyrococcus horikoshii; Sarin; Soman; Temperature | 2011 |
Quantification of nerve agent adducts with albumin in rat plasma using liquid chromatography-isotope dilution tandem mass spectrometry.
Topics: Animals; Biomarkers; Butyrylcholinesterase; Chromatography, Liquid; Limit of Detection; Male; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sarin; Serum Albumin; Soman; Tandem Mass Spectrometry; Tyrosine | 2012 |
Reaction of nerve agents with phosphate buffer at pH 7.
Topics: Buffers; Chemical Warfare Agents; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Organothiophosphorus Compounds; Phosphates; Sarin; Soman; Water | 2012 |
Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.
Topics: Bacterial Proteins; Catalysis; Catalytic Domain; Chemical Warfare Agents; Crystallography, X-Ray; Enterobacter aerogenes; Gene Library; High-Throughput Screening Assays; Hydrolysis; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Organophosphorus Compounds; Phosphoric Diester Hydrolases; Phosphoric Triester Hydrolases; Recombinant Proteins; Sarin; Soman; Stereoisomerism | 2012 |
Determination of LCt(50)s in anesthetized rats exposed to aerosolized nerve agents.
Topics: Administration, Inhalation; Aerosols; Anesthesia; Animals; Chemical Warfare Agents; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Neurotoxins; Organothiophosphorus Compounds; Rats; Sarin; Soman | 2013 |
Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection.
Topics: Animals; Antidotes; Aryldialkylphosphatase; Chemical Warfare Agents; Chlorpyrifos; Guinea Pigs; Humans; Male; Mice; Moths; Organophosphates; Organophosphorus Compounds; Pesticides; Recombinant Proteins; Sarin; Soman | 2013 |
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
Topics: Amino Acid Substitution; Antidotes; Aryldialkylphosphatase; Catalytic Domain; Chemical Warfare Agents; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman; Substrate Specificity | 2013 |
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman | 2013 |
Comparison of high-resolution and tandem mass spectrometry for the analysis of nerve agent metabolites in urine.
Topics: Chemical Warfare Agents; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Tandem Mass Spectrometry | 2013 |
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).
Topics: Aryldialkylphosphatase; Aurintricarboxylic Acid; Butyrylcholinesterase; Calcium; Chemical Warfare Agents; Cholinesterase Inhibitors; Edetic Acid; Freezing; Half-Life; Humans; Inactivation, Metabolic; Organophosphates; Organophosphorus Compounds; Plasma; Sarin; Soman | 2014 |
Organophosphorus pesticide and ester analysis by using comprehensive two-dimensional gas chromatography with flame photometric detection.
Topics: Calibration; Chemical Warfare; Chromatography, Gas; Gasoline; Hydrocarbons; Kerosene; Limit of Detection; Organophosphates; Organophosphorus Compounds; Pesticides; Phosphorus; Photometry; Sarin; Soil; Soil Pollutants; Soman; Temperature | 2013 |
Detection of nerve agents using proton transfer reaction mass spectrometry with ammonia as reagent gas.
Topics: Ammonia; Chemical Warfare Agents; Mass Spectrometry; Models, Chemical; Organophosphates; Organophosphonates; Organophosphorus Compounds; Protons; Sarin; Soman; Water | 2013 |
Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.
Topics: Ammonium Compounds; Biotransformation; Buffers; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Fluorides; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Limit of Detection; Organophosphorus Compounds; Organothiophosphorus Compounds; Quaternary Ammonium Compounds; Sarin; Solid Phase Extraction; Soman; Tandem Mass Spectrometry | 2014 |
Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
Topics: Biotransformation; Chemical Warfare Agents; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Indicator Dilution Techniques; Limit of Detection; Liquid-Liquid Extraction; Organophosphonates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2014 |
Novel human butyrylcholinesterase variants: toward organophosphonate detoxication.
Topics: Butyrylcholinesterase; Butyrylthiocholine; Chemical Warfare Agents; Cholinesterase Inhibitors; Directed Molecular Evolution; Humans; Hydrolysis; Kinetics; Molecular Dynamics Simulation; Organophosphorus Compounds; Recombinant Proteins; Sarin; Soman | 2014 |
Selective chromo-fluorogenic detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) with a unique probe based on a boron dipyrromethene (BODIPY) dye.
Topics: Acetonitriles; Boron Compounds; Chemical Warfare Agents; Color; Colorimetry; Humans; Limit of Detection; Membranes, Artificial; Molecular Mimicry; Molecular Probes; Organophosphates; Phosphorylation; Reagent Strips; Sarin; Silica Gel; Solvents; Soman; Substrate Specificity | 2014 |
Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.
Topics: Blood Chemical Analysis; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Organophosphorus Compounds; Organothiophosphorus Compounds; Reproducibility of Results; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Time Factors; Tyrosine | 2014 |
Chiral separation of G-type chemical warfare nerve agents via analytical supercritical fluid chromatography.
Topics: Chemical Warfare Agents; Chromatography, Supercritical Fluid; Mass Spectrometry; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2014 |
Identification of chemical warfare agents from vapor samples using a field-portable capillary gas chromatography/membrane-interfaced electron ionization quadrupole mass spectrometry instrument with Tri-Bed concentrator.
Topics: Chemical Warfare Agents; Chemistry Techniques, Analytical; Gas Chromatography-Mass Spectrometry; Gases; Mechlorethamine; Mustard Gas; Organophosphates; Sarin; Soman | 2015 |
Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis.
Topics: Adsorption; Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Phenols; Polymers; Sarin; Soman; Volatilization | 2015 |
Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase.
Topics: Aluminum; Catalytic Domain; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Metals; Molecular Docking Simulation; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman; Stereoisomerism | 2016 |
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Half-Life; Humans; Kinetics; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Oximes; Phenols; Pralidoxime Compounds; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship | 2016 |
A Rapid and Sensitive Strip-Based Quick Test for Nerve Agents Tabun, Sarin, and Soman Using BODIPY-Modified Silica Materials.
Topics: Boron Compounds; Chemical Warfare Agents; Nerve Agents; Organophosphates; Prothrombin Time; Sarin; Silicon Dioxide; Soman | 2016 |
Analysis of Nerve Agent Metabolites from Hair for Long-Term Verification of Nerve Agent Exposure.
Topics: Chemical Warfare Agents; Chromatography, High Pressure Liquid; Hair; Humans; Limit of Detection; Nerve Agents; Organophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Exploration of Unimolecular Gas-Phase Detoxication Pathways of Sarin and Soman: A Computational Study from the Perspective of Reaction Energetics and Kinetics.
Topics: Gases; Kinetics; Molecular Structure; Phase Transition; Sarin; Soman; Thermodynamics | 2016 |
Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study.
Topics: Animals; Arsenicals; Blister; Chemical Warfare Agents; Cholinesterase Inhibitors; Cockroaches; Female; Male; Mustard Gas; Nerve Agents; Organophosphorus Compounds; Pilot Projects; Sarin; Soman | 2016 |
Coupling Activity-Based Detection, Target Amplification, Colorimetric and Fluorometric Signal Amplification, for Quantitative Chemosensing of Fluoride Generated from Nerve Agents.
Topics: Colorimetry; Fluorescent Dyes; Fluorides; Isoflurophate; Nerve Agents; Organophosphorus Compounds; Oximes; Phosphates; Sarin; Soman; Spectrometry, Fluorescence | 2017 |
Rapid IC-MS/MS determination of methylphosphonic acid in urine of rats exposed to organophosphorus nerve agents.
Topics: Animals; Limit of Detection; Linear Models; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Reproducibility of Results; Sarin; Soman; Tandem Mass Spectrometry | 2017 |
Determination of trace amounts of G-type nerve agents in aqueous samples utilizing "in vial" instantaneous derivatization and liquid chromatography-tandem mass spectrometry.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Hydrolysis; Limit of Detection; Nerve Agents; Sarin; Soman; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2017 |
An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aryldialkylphosphatase; Biocatalysis; Kinetics; Mutagenesis, Site-Directed; Nerve Agents; Organophosphorus Compounds; Recombinant Proteins; Sarin; Soman; Stereoisomerism; Substrate Specificity | 2018 |
Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A
Topics: Acetylcholinesterase; Adenosine; Adenosine A1 Receptor Agonists; Animals; Molecular Structure; Nerve Agents; Organophosphorus Compounds; Quantum Theory; Rats; Sarin; Soman; Thermodynamics | 2018 |
pH-Dependent Piecewise Linear Correlation of
Topics: Chemical Warfare Agents; Humans; Hydrogen; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nerve Agents; Phosphorus Isotopes; Sarin; Soman | 2018 |
Investigation of dried blood sampling with liquid chromatography tandem mass spectrometry to confirm human exposure to nerve agents.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Tandem Mass Spectrometry | 2018 |
Aqueous extraction followed by derivatization and liquid chromatography-mass spectrometry analysis: A unique strategy for trace detection and identification of G-nerve agents in environmental matrices.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Hydrolysis; Limit of Detection; Nerve Agents; Organophosphorus Compounds; Sarin; Soil; Soman; Tandem Mass Spectrometry; Water | 2018 |
Methylation protocol for the retrospective detection of isopropyl-, pinacolyl- and cyclohexylmethylphosphonic acids, indicative markers for the nerve agents sarin, soman and cyclosarin, at low levels in soils using EI-GC-MS.
Topics: Biomarkers; Gas Chromatography-Mass Spectrometry; Methylation; Nerve Agents; Organophosphorus Compounds; Retrospective Studies; Sarin; Soil; Soil Pollutants; Soman | 2019 |
"Covalent-Assembly"-Based Fluorescent Probe for Detection of a Nerve-Agent Mimic (DCP) via Lossen Rearrangement.
Topics: Aniline Compounds; Biphenyl Compounds; Chemical Warfare Agents; Fluorescent Dyes; Humans; Isocyanates; Kinetics; Limit of Detection; Molecular Mimicry; Organophosphates; Organophosphorus Compounds; Phenanthridines; Sarin; Soman; Spectrometry, Fluorescence | 2019 |
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Topics: Antidotes; Bacterial Proteins; Caulobacteraceae; Drug Stability; Enzyme Stability; Hot Temperature; Mutation; Nerve Agents; Organophosphate Poisoning; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidation-Reduction; Phosphoric Triester Hydrolases; Protein Denaturation; Recombinant Proteins; Sarin; Soman | 2020 |
Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
Topics: Animals; Bone and Bones; Chemical Warfare Agents; Chromatography, Liquid; Humans; Limit of Detection; Nerve Agents; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Swine | 2020 |
Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A.
Topics: Acetylcholinesterase; Binding Sites; Cathepsin A; Cell Line; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Gene Expression; GPI-Linked Proteins; HEK293 Cells; Humans; Isoflurophate; Kinetics; Models, Molecular; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Sarin; Soman; Substrate Specificity; Time Factors | 2020 |
Sensitive Untargeted Screening of Nerve Agents and Their Degradation Products Using Liquid Chromatography-High Resolution Mass Spectrometry.
Topics: Chemical Warfare Agents; Chromatography, Liquid; Databases, Chemical; Mass Spectrometry; Organothiophosphorus Compounds; Sarin; Sensitivity and Specificity; Small Molecule Libraries; Soman | 2020 |
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors | 2020 |
Improving Quantification of tabun, sarin, soman, cyclosarin, and sulfur mustard by focusing agents: A field portable gas chromatography-mass spectrometry study.
Topics: Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organophosphorus Compounds; Reference Standards; Sarin; Soman | 2021 |
Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Brain; Deoxyadenosines; Disease Models, Animal; Drug Administration Schedule; Injections, Intramuscular; Male; Neuroprotective Agents; Norbornanes; Rats, Sprague-Dawley; Sarin; Soman; Status Epilepticus; Time Factors | 2021 |
Detection of Chemical Warfare Agents with a Miniaturized High-Performance Drift Tube Ion Mobility Spectrometer Using High-Energetic Photons for Ionization.
Topics: Chemical Warfare Agents; Mustard Gas; Nerve Agents; Sarin; Soman | 2022 |