Page last updated: 2024-08-18

soman and pralidoxime

soman has been researched along with pralidoxime in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (25.64)	18.7374
1990's	14 (35.90)	18.2507
2000's	12 (30.77)	29.6817
2010's	3 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL	1
Mays, MZ; Murrow, ML; Romano, JA; Terry, MR	1
Shih, T; Valdes, JJ; Whalley, CE	1
Culp, DJ; Marin, MG; McBride, RK; Stone, KK; Zwierzynski, DJ	1
Anderson, DR; Harris, LW; Lennox, WJ; Pastelak, AM; Vanderpool, BA; Woodard, CL	1
Anthony, A; Doebler, JA; Martin, LJ	1
Culp, DJ; Marin, MG; McBride, RK; Zwierzynski, D	1
Grubic, Z; Tomazic, A	1
Doukas, PH; O'Neill, JJ; Sheldon, RJ; Sterling, GH	1
Chou, TC; Li, FZ; Sun, MC	1
Chang, TC; Ferrick, DA; Gray, AP; Kramer, DN; Leverone, TR; Platz, RD	1
Anderson, DR; Harris, LW; Lennox, WJ; Talbot, BG	1
Green, MD; Kaminskis, A; Reid, F	1
Anthony, A; Bocan, TM; Doebler, JA; Moore, RA; Shih, TM	1
Bosković, B; Jovanović, D; Kovacević, V	1
Blick, DW; Brown, GC; Hartgraves, SL; Murphy, MR	1
Smith, AP	1
Koplovitz, I; Stewart, JR	1
Beers, ET; Brennecke, LH; Sparenborg, S	1
Baubichon, D; Blanchet, G; Brochier, G; Clarencon, D; Galonnier, M; Lallement, G; Mestries, JC	1
Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Masqueliez, C; Mestries, JC; Peoc'h, M	1
Knopff, O; Szinicz, L; Widmann, R; Worek, F	1
Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M	1
McDonough, JH; Shih, TM	1
Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Jourdil, N; Lallement, G; Peoc'h, M; Renault, F	1
Go, ML; Loke, WK; Sim, MK	2
Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM	1
Newmark, J	1
Aas, P; Tansø, R; Øydvin, OK	1
Kellar, KJ	1
Bajgar, J; Jun, D; Kuca, K	1
Hrobak, PK	1
Ashani, Y; Colletier, JP; Froment, MT; Greenblatt, HM; Masson, P; Nachon, F; Sanson, B; Silman, I; Sussman, JL; Toker, L; Weik, M	1
Halamek, E; Hoskovcova, M; Kobliha, Z	1
Auta, J; Brown, A; Doctor, BP; Guiodotti, A; Jensen, N; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y; Wood, E	1
de Koning, M; Goeldner, M; Loiodice, M; Nachon, F; Noort, D; Saurel, L; van Grol, M; Wandhammer, M	1
Cadieux, CL; Cerasoli, D; Koenig, JA; Koh, J; McDonough, J; Shih, TM; Wang, H; Zhang, Y	1

Reviews

1 review(s) available for soman and pralidoxime

Article	Year
Therapy for nerve agent poisoning. Archives of neurology, 2004, Volume: 61, Issue:5 Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman	2004

Other Studies

38 other study(ies) available for soman and pralidoxime

Article	Year
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats. Drug and chemical toxicology, 1992, Volume: 15, Issue:4 Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman	1992
Protection from lethality and behavioral incapacitation resulting from intoxication by soman (pinacolyl methylphosphonofluoridate) and treatment with atropine sulfate and 2-PAM chloride in the guinea pig, cavia porcellus. Drug and chemical toxicology, 1991, Volume: 14, Issue:1-2 Topics: Animals; Atropine; Avoidance Learning; Cholinesterase Reactivators; Drug Therapy, Combination; Guinea Pigs; Lethal Dose 50; Male; Pralidoxime Compounds; Soman	1991
A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning. Toxicology letters, 1991, Volume: 55, Issue:2 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Drug Interactions; Lethal Dose 50; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Soman	1991
Variable effects of soman on macromolecular secretion by ferret trachea. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 16, Issue:1 Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Ferrets; L-Lactate Dehydrogenase; Male; Organ Culture Techniques; Pralidoxime Compounds; Soman; Sulfates; Sulfur Radioisotopes; Trachea	1991
Evaluation of several oximes as reactivators of unaged soman-inhibited whole blood acetylcholinesterase in rabbits. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Acetylcholinesterase; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Diaphragm; Dose-Response Relationship, Drug; Imidazoles; Medulla Oblongata; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Soman; Time Factors	1990
Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites. Journal of the neurological sciences, 1985, Volume: 71, Issue:1 Topics: Animals; Antidotes; Cholinesterase Reactivators; Cholinesterases; Corpus Striatum; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA; Soman; Thalamic Nuclei	1985
Effects of soman and its antidotes on tracheal mucociliary transport of ferrets. Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:3 Topics: Animals; Atropine; Blood Pressure; Carbon Dioxide; Cholinesterase Reactivators; Ferrets; Heart Rate; Hydrogen-Ion Concentration; Male; Mucociliary Clearance; Oxygen; Partial Pressure; Pralidoxime Compounds; Reference Values; Soman; Trachea	1989
Mechanism of action of HI-6 on soman inhibition of acetylcholinesterase in preparations of rat and human skeletal muscle; comparison to SAD-128 and PAM-2. Archives of toxicology, 1989, Volume: 63, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Female; Humans; In Vitro Techniques; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman	1989
In vivo protection against soman toxicity by known inhibitors of acetylcholine synthesis in vitro. Biochemical pharmacology, 1988, Feb-01, Volume: 37, Issue:3 Topics: Acetylcholine; Animals; Atropine; Cholinesterase Reactivators; Hemicholinium 3; Kinetics; Lethal Dose 50; Male; Pralidoxime Compounds; Rats; Rats, Inbred Strains; Soman; Structure-Activity Relationship	1988
Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes. Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Reactivators; Erythrocytes; Humans; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman	1986
Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase. Journal of medicinal chemistry, 1985, Volume: 28, Issue:1 Topics: Acetylcholinesterase; Alkylation; Ammonia; Animals; Cholinesterase Inhibitors; Enzyme Activation; Erythrocyte Aging; Organophosphorus Compounds; Pralidoxime Compounds; Quaternary Ammonium Compounds; Rats; Soman; Time Factors	1985
Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality. Life sciences, 1985, Sep-02, Volume: 37, Issue:9 Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Guinea Pigs; Male; Mecamylamine; Organophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Pyridostigmine Bromide; Rats; Soman	1985
Correlation of 2-PAM plasma levels after organophosphate intoxication. Research communications in chemical pathology and pharmacology, 1985, Volume: 49, Issue:2 Topics: Animals; Female; Guinea Pigs; Insecticides; Male; Pralidoxime Compounds; Sarin; Soman	1985
Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments. Neurochemical research, 1983, Volume: 8, Issue:8 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Caudate Nucleus; Cerebral Cortex; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Neurons; Organophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Rats; Rats, Inbred Strains; RNA; Soman	1983
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity	1984
Treatment of nerve gas poisoning. The Medical letter on drugs and therapeutics, 1995, May-12, Volume: 37, Issue:948 Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman	1995
Primate performance decrements following acute soman exposure: failure of chemical countermeasures. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3 Topics: Animals; Atropine; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Macaca mulatta; Male; Pralidoxime Compounds; Psychomotor Performance; Pyridostigmine Bromide; Soman	1994
Long-term effects of the anticholinesterases sarin and soman on latencies of muscle action potentials in mouse diaphragm muscle. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:3 Topics: Action Potentials; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Erythrocytes; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Muscles; Sarin; Soman	1993
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit. Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms	1994
Pharmacological dissociation of the motor and electrical aspects of convulsive status epilepticus induced by the cholinesterase inhibitor soman. Epilepsy research, 1993, Volume: 14, Issue:2 Topics: Analysis of Variance; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Electroencephalography; Guinea Pigs; Image Processing, Computer-Assisted; Male; Pralidoxime Compounds; Pyridostigmine Bromide; Scopolamine; Soman; Status Epilepticus	1993
Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2 Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Macaca fascicularis; Male; Oximes; Poisoning; Pralidoxime Compounds; Prodrugs; Pyridinium Compounds; Soman	1997
Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11. Archives of toxicology, 1998, Volume: 72, Issue:2 Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Diazepam; Drug Combinations; Excitatory Amino Acid Antagonists; Injections, Intravenous; Macaca fascicularis; Male; Muscarinic Antagonists; Neuroprotective Agents; Piperidines; Pralidoxime Compounds; Seizures; Soman; Staining and Labeling; Time Factors	1998
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Archives of toxicology, 1998, Volume: 72, Issue:4 Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman	1998
Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support. Archives of toxicology, 1999, Volume: 73, Issue:2 Topics: Animals; Anticonvulsants; Antidotes; Atropine; Brain; Cerebellum; Cerebral Cortex; Chemical Warfare Agents; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Diazepam; Drug Therapy, Combination; Electrocardiography; Excitatory Amino Acid Antagonists; Haplorhini; Macaca fascicularis; Male; Piperidines; Poisoning; Pralidoxime Compounds; Seizures; Soman; Time Factors	1999
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication. Archives of toxicology, 2000, Volume: 74, Issue:3 Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman	2000
Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics. Archives of toxicology, 2000, Volume: 74, Issue:8 Topics: Animals; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electroencephalography; Macaca fascicularis; Male; Pralidoxime Compounds; Soman	2000
O-Substituted derivatives of pralidoxime: muscarinic properties and protection against soman effects in rats. European journal of pharmacology, 2002, May-10, Volume: 442, Issue:3 Topics: Acetylcholinesterase; Animals; Atropine; Binding, Competitive; Blood Pressure; Brain; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Myocardium; Oximes; Pralidoxime Compounds; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Respiration; Soman; Structure-Activity Relationship; Submandibular Gland	2002
Effects of fosphenytoin on nerve agent-induced status epilepticus. Drug and chemical toxicology, 2004, Volume: 27, Issue:1 Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Injections, Intraperitoneal; Male; Phenytoin; Pralidoxime Compounds; Pyridostigmine Bromide; Soman; Status Epilepticus	2004
Pre-junctional effects of oximes on [3H]-acetylcholine release in rat hippocampal slices during soman intoxication. European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3 Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Potassium; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tritium	2005
Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents. European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Atropine; Benzene Derivatives; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corpus Striatum; Dopamine; Drug Synergism; Electroencephalography; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Mice; Microdialysis; Neuroprotective Agents; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Serotonin; Soman; Survival Rate; Time Factors	2005
Overcoming inhibitions. Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-05, Volume: 103, Issue:36 Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors	2006
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug and chemical toxicology, 2007, Volume: 30, Issue:1 Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime	2007
Nerve agents: implications for anesthesia providers. AANA journal, 2008, Volume: 76, Issue:2 Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors	2008
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime. Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23 Topics: Acetylcholinesterase; Animals; Catalytic Domain; Cholinesterase Inhibitors; Crystallography, X-Ray; Dealkylation; Enzyme Activation; Humans; Kinetics; Models, Molecular; Pralidoxime Compounds; Soman; Torpedo; Water	2009
Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman. Neuro endocrinology letters, 2009, Volume: 30 Suppl 1 Topics: Acetylcholinesterase; Biosensing Techniques; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzymes, Immobilized; Isomerism; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Soman	2009
Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs. Neurotoxicology, 2012, Volume: 33, Issue:2 Topics: Acetylcholinesterase; Analysis of Variance; Animals; Atropine; Benzodiazepines; Body Weight; Brain; Chemical Warfare Agents; Cholinesterase Reactivators; Disease Models, Animal; Drug Administration Schedule; Electrocardiography; Electroencephalography; Guinea Pigs; Imidazoles; Lethal Dose 50; Male; Muscarinic Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Pralidoxime Compounds; Seizures; Soman; Telemetry; Time Factors	2012
A step toward the reactivation of aged cholinesterases--crystal structure of ligands binding to aged human butyrylcholinesterase. Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1 Topics: Alkylation; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Crystallography, X-Ray; Humans; Kinetics; Ligands; Models, Molecular; Phosphorylation; Pralidoxime Compounds; Recombinant Proteins; Serine; Soman	2013
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Half-Life; Humans; Kinetics; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Oximes; Phenols; Pralidoxime Compounds; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship	2016