soman has been researched along with physostigmine in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (29.85) | 18.7374 |
| 1990's | 27 (40.30) | 18.2507 |
| 2000's | 13 (19.40) | 29.6817 |
| 2010's | 7 (10.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harris, LW; Heyl, WC; Moore, RD; Stitcher, DL | 1 |
| Aas, P; Fyllingen, E; Walday, P | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Murrow, ML; Solana, RP; Wade, JV | 1 |
| Karlsson, N; Larsson, R; Puu, G | 1 |
| Anderson, DR; Bowersox, SL; Harris, LW; Lennox, WJ; Pastelak, AM; Vanderpool, BA | 1 |
| Clement, JG | 3 |
| Adams, N; Corcoran, K; Kaminskis, A; Maitland, G; von Bredow, J; Wade, J | 1 |
| Ho, IK; Hoskins, B; Lim, DK | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP | 2 |
| French, MC; Wetherell, JR | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG | 1 |
| Bonds, AB; Corbett, GK; DeBruyn, EJ | 1 |
| Anderson, D; Carchman, RA; Carter, WH; Gennings, C; Harris, LW; Lennox, WJ; Solana, RP | 1 |
| Anderson, DR; Harris, LW; Pastelak, AM; Vanderpool, B | 1 |
| Carchman, RA; Carter, WH; Gennings, C; Harris, LW; Solana, RP; Talbot, BG | 1 |
| Boyle, RM; Campbell, ED; Carchman, RA; Carter, WH; Gennings, C; Harris, LW; Solana, RP; Talbot, BG | 1 |
| Buccafusco, JJ; Chon, SH; Heithold, DL | 1 |
| Gross, CL; Kagey-Sobotka, A; Kilduff, JE; Meier, HL; Papirmeister, B | 1 |
| Ho, IK; Hoskins, B; Ito, Y; Lim, DK; Yu, ZJ | 1 |
| Benschop, HP; De Bisschop, HC; Johnson, MK; Read, DJ; Willems, JL | 1 |
| Davis, LH; Kauffman, FC; Viana, GB | 1 |
| Brecht, KM; Lenz, DE; Maxwell, DM; O'Neill, BL | 1 |
| Brezenoff, HE; McGee, J | 1 |
| Dawson, RM; Gray, PJ | 1 |
| Fonnum, F; Sterri, SH | 1 |
| Bonds, AB; DeBruyn, EJ; Gajewski, YA | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Talbot, BG | 1 |
| Inns, RH; Leadbeater, L; Rylands, JM | 1 |
| Winbladh, B | 1 |
| Anthony, A; Bocan, TM; Doebler, JA; Moore, RA; Shih, TM | 1 |
| Cohen, Y; Coudray-Lucas, C; Prioux-Guyonneau, M; Sentenac, H; Wepierre, J | 2 |
| Anderson, DR; Harris, LW; Lennox, WJ; Swanson, DR; Talbot, BG | 1 |
| Cohen, Y; Coq, HM; Coudray-Lucas, C; Prioux-Guyonneau, M; Tassel, A; Wepierre, J | 1 |
| Harris, LW; Heyl, WC; Stitcher, DL | 1 |
| Wetherell, JR | 1 |
| Blick, DW; Brown, GC; Murphy, MR; Weathersby, FR | 1 |
| Ashani, Y; Doctor, BP; Grunwald, J; Raveh, L | 1 |
| Blick, DW; Brown, GC; Miller, SA; Murphy, MR | 1 |
| Sket, D | 1 |
| Blick, DW; Kerenyi, SZ; Miller, SA; Murphy, MR | 1 |
| Jenden, DJ; Li, MG; Scremin, OU; Shih, TM | 1 |
| Bruijnzeel, PL; Busker, RW; Melchers, BP; Olivier, B; Philippens, IH; Wolthuis, OL | 1 |
| Bruijnzeel, PL; Melchers, BP; Olivier, B; Philippens, IH | 1 |
| Hänninen, O; Tuovinen, K | 1 |
| Bruijnzeel, PL; Groen, B; Melchers, BP; Olivier, B; Philippens, IH; Vanwersch, RA | 1 |
| Ben Nathan, D; Danenberg, HD; Grauer, E; Kapon, J; Kobiler, D; Lustig, S | 1 |
| Baubichon, D; Carpentier, P; Dorandeu, F; Foquin, A; Lallement, G | 1 |
| Bowditch, AP; Crofts, HS; Muggleton, NG; Pearce, PC; Scott, EA | 1 |
| Aas, P; Enger, S; Myhrer, T | 2 |
| Tuovinen, K | 1 |
| Aas, P; Andersen, JM; Myhrer, T; Nguyen, NH | 1 |
| Che, JH; Choi, EK; Ha, YC; Hur, GH; Hwang, SY; Jang, JY; Kim, DJ; Kim, J; Kim, JC; Kim, YB; Park, D; Seong, YH; Shin, S; Yon, JM | 1 |
| Joosen, MJ; Philippens, IH; Vanwersch, RA | 1 |
| Cho, Y; Choi, EK; Huang, ZZ; Hwang, SY; Kang, JK; Kim, JC; Kim, WS; Kim, YB; Nam, SY; Park, SH; Shin, S | 1 |
| Armstrong, S; Mumford, H; Price, M; Scott, L; Wetherell, J | 1 |
| Bumm, R; Eckert, S; Eyer, P; Herkert, NM; Thiermann, H; Weber, G; Worek, F | 1 |
| Joosen, MJ; Smit, AB; van Helden, HP | 1 |
| Hatz, RA; Herkert, NM; Schulz, S; Thiermann, H; Wille, T; Worek, F | 1 |
| Herkert, NM; Thiermann, H; Worek, F | 1 |
| Cho, Y; Ha, YC; Hur, GH; Kim, WS | 1 |
| Aas, P; Enger, S; Mariussen, E; Myhrer, T | 1 |
| Chen, C; Chen, J; Greig, NH; He, J; Iskandar, K; Jacobowitz, DM; Marini, AM; McDonough, JH; Pan, H; Piermartiri, T; Wu, W; Yu, QS | 1 |
67 other study(ies) available for soman and physostigmine
| Article | Year |
|---|---|
Effect of atropine and/or physostigmine on cerebral acetylcholine in rats poisoned with soman.
Topics: Acetylcholine; Animals; Atropine; Brain; Brain Chemistry; Cholinesterase Inhibitors; Drug Interactions; Male; Neostigmine; Organophosphate Poisoning; Physostigmine; Rats; Soman | 1978 |
Effect of calcium antagonists (omega-conotoxin GVIA, verapamil, gallopamil, diltiazem) on bronchial smooth muscle contractions induced by soman.
Topics: Acetylcholinesterase; Animals; Bronchi; Butyrylcholinesterase; Calcium Channel Blockers; Carbachol; Electric Stimulation; Male; Muscle Contraction; Muscle, Smooth; Physostigmine; Rats; Rats, Wistar; Soman; Vagus Nerve | 1992 |
Successful pretreatment/therapy of soman, sarin and VX intoxication.
Topics: Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Phenylpropionates; Physostigmine; Poisoning; Sarin; Soman; Trihexyphenidyl; Tropanes | 1992 |
Protection of guinea pigs against soman poisoning with ferrocene carbamate.
Topics: Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Ferrous Compounds; Guinea Pigs; Lethal Dose 50; Male; Metallocenes; Organometallic Compounds; Oximes; Physostigmine; Pyridinium Compounds; Soman | 1992 |
Acetylcholinesterase inhibition and anti-soman efficacy of homologs of physostigmine.
Topics: Acetylcholinesterase; Animals; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Female; Guinea Pigs; Male; Physostigmine; Soman; Structure-Activity Relationship | 1992 |
Effect of a single dose of an acetylcholinesterase inhibitor on oxotremorine- and nicotine-induced hypothermia in mice.
Topics: Animals; Body Temperature; Cholinesterase Inhibitors; Down-Regulation; Drug Tolerance; Male; Mice; Nicotine; Oxotremorine; Physostigmine; Receptors, Muscarinic; Receptors, Nicotinic; Soman | 1991 |
Efficacy evaluation of physostigmine and anticholinergic adjuncts as a pretreatment for nerve agent intoxication.
Topics: Animals; Cholinesterases; Erythrocytes; Female; Lethal Dose 50; Macaca fascicularis; Male; Nervous System Diseases; Parasympatholytics; Physostigmine; Scopolamine; Soman; Trihexyphenidyl | 1991 |
Trihexyphenidyl enhances physostigmine prophylaxis against soman poisoning in guinea pigs.
Topics: Animals; Body Weight; Brain; Drinking; Drug Interactions; Guinea Pigs; Kinetics; Lethal Dose 50; Male; Membrane Proteins; Physostigmine; Pirenzepine; Quinuclidinyl Benzilate; Reflex; Seizures; Soman; Trihexyphenidyl | 1991 |
Effects of subacute pretreatment with carbamate together with acute adjunct pretreatment against nerve agent exposure.
Topics: Animals; Carbamates; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Physostigmine; Scopolamine; Soman; Trihexyphenidyl | 1991 |
A comparison of the decarbamoylation rates of physostigmine-inhibited plasma and red cell cholinesterases of man with other species.
Topics: Acetylcholinesterase; Animals; Callitrichinae; Cholinesterase Inhibitors; Cholinesterases; Erythrocyte Volume; Erythrocytes; Female; Guinea Pigs; Humans; Macaca mulatta; Male; Physostigmine; Plasma; Plasma Cells; Poisoning; Soman; Species Specificity; Time Factors | 1991 |
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl | 1991 |
Pretreatment with physostigmine, mecamylamine and atropine reduces the impact of soman on the cortical visual evoked potential of the cat.
Topics: Animals; Atropine; Cats; Cholinesterase Inhibitors; Cholinesterases; Depression, Chemical; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Evoked Potentials, Visual; Mecamylamine; Physostigmine; Soman; Time Factors; Visual Cortex | 1991 |
Evaluation of the efficacy of two carbamates, physostigmine and pyridostigmine, when used in conjunction for protection against organophosphate exposure.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Models, Biological; Organophosphorus Compounds; Physostigmine; Pyridostigmine Bromide; Regression Analysis; Soman | 1990 |
Acetylcholinesterase inhibition by (+)physostigmine and efficacy against lethality induced by soman.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Female; Guinea Pigs; Male; Physostigmine; Soman; Stereoisomerism; Trihexyphenidyl | 1990 |
Evaluation of a two-drug combination pretreatment against organophosphorus exposure.
Topics: Animals; Cholinesterase Inhibitors; Drug Therapy, Combination; Erythrocytes; Female; Guinea Pigs; Lethal Dose 50; Male; Phenylpropionates; Physostigmine; Soman; Tropanes | 1990 |
Assessing the efficacy of azaprophen and physostigmine as a pretreatment for soman-induced incapacitation in guinea pigs by response-surface modeling.
Topics: Animals; Confidence Intervals; Drug Therapy, Combination; Female; Guinea Pigs; Male; Models, Biological; Parasympatholytics; Phenylpropionates; Physostigmine; Soman; Tropanes | 1990 |
Long-term behavioral and learning abnormalities produced by the irreversible cholinesterase inhibitor soman: effect of a standard pretreatment regimen and clonidine.
Topics: Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Injections, Intramuscular; Lethal Dose 50; Male; Physostigmine; Rats; Rats, Inbred Strains; Soman; Trihexyphenidyl | 1990 |
Histamine release by esterase inhibitors. The regulation of histamine release from human leukocytes of allergic and non-allergic individuals by the serine esterase inhibitors diisopropyl fluorophosphate and pinacolyl methylphosphorofluoridate.
Topics: Enzyme Inhibitors; Esterases; Histamine Release; Humans; Hypersensitivity; Isoflurophate; Kinetics; Organophosphorus Compounds; Physostigmine; Pyridostigmine Bromide; Soman; Temperature | 1985 |
Effects of subacute administration of physostigmine on blood acetylcholinesterase activity, motor performance, and soman intoxication.
Topics: Acetylcholinesterase; Animals; Male; Motor Activity; Physostigmine; Rats; Scopolamine; Soman | 1989 |
Prevention of soman toxicity after the continuous administration of physostigmine.
Topics: Acetylcholinesterase; Animals; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Guinea Pigs; Infusion Pumps; Male; Physostigmine; Scopolamine; Soman; Time Factors | 1988 |
High doses of soman protect against organophosphorus-induced delayed polyneuropathy but tabun does not.
Topics: Animals; Ataxia; Atropine; Carboxylic Ester Hydrolases; Chickens; Diazepam; Drug Interactions; Female; Isoflurophate; Isomerism; Organophosphates; Organophosphorus Compounds; Physostigmine; Soman | 1988 |
Effects of organophosphates and nerve growth factor on muscarinic receptor binding number in rat pheochromocytoma PC12 cells.
Topics: Animals; Atropine; Cholinesterases; Dose-Response Relationship, Drug; N-Methylscopolamine; Nerve Growth Factors; Organophosphorus Compounds; Pheochromocytoma; Phosphorylation; Physostigmine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Soman; Tumor Cells, Cultured | 1988 |
Effect of carboxylesterase inhibition on carbamate protection against soman toxicity.
Topics: Acetylcholinesterase; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Guinea Pigs; Lethal Dose 50; Male; Organophosphorus Compounds; Physostigmine; Pyridostigmine Bromide; Rabbits; Rats; Rats, Inbred Strains; Soman | 1988 |
Protection by physostigmine against the pressor effect of soman in the rat.
Topics: Acetylcholinesterase; Animals; Blood Pressure; Male; Physostigmine; Rats; Soman | 1987 |
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman | 1987 |
Carboxylesterases in guinea-pig plasma and liver. Tissue specific reactivation by diacetylmonoxime after soman inhibition in vitro.
Topics: Animals; Butanones; Carboxylic Ester Hydrolases; Chromatography, Affinity; Diacetyl; Enzyme Reactivators; Female; Guinea Pigs; In Vitro Techniques; Isoelectric Focusing; Isoelectric Point; Liver; Nitrophenols; Organophosphorus Compounds; Physostigmine; Soman | 1987 |
Anticholinesterase agents affect contrast gain of the cat cortical visual evoked potential.
Topics: Acetylcholine; Animals; Atropine; Cats; Cholinesterase Inhibitors; Evoked Potentials, Visual; Isoflurophate; Physostigmine; Pyridostigmine Bromide; Soman; Visual Cortex; Visual Perception | 1986 |
Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Guinea Pigs; Male; Mecamylamine; Organophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Pyridostigmine Bromide; Rats; Soman | 1985 |
Treatment of poisoning by soman.
Topics: Animals; Antidotes; Atropine; Carbamates; Diazepam; Guinea Pigs; Male; Motor Activity; Organophosphate Poisoning; Parasympatholytics; Phenylpropionates; Physostigmine; Pyridostigmine Bromide; Sarin; Soman; Time Factors | 1985 |
Choroid plexus uptake of acetylcholine.
Topics: Acetylcholine; Albumins; Animals; Biological Transport, Active; Choline; Cholinesterases; Choroid Plexus; Culture Techniques; Depression, Chemical; Iodine Radioisotopes; Methods; Physostigmine; Rabbits; Salicylates; Sarin; Soman; Stimulation, Chemical; Sulfates; Time Factors; Tritium | 1974 |
Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Caudate Nucleus; Cerebral Cortex; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Neurons; Organophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Rats; Rats, Inbred Strains; RNA; Soman | 1983 |
Effects of physostigmine, paraoxon and soman on brain GABA level and metabolism.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Brain; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Organophosphorus Compounds; Paraoxon; Physostigmine; Rats; Rats, Inbred Strains; Soman; Vigabatrin | 1984 |
Toxicity of anticholinesterases: interactions of pyridostigmine and physostigmine with soman.
Topics: Acetylcholinesterase; Animals; Drug Interactions; Lethal Dose 50; Male; Motor Activity; Organophosphorus Compounds; Physostigmine; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Soman | 1984 |
Brain catecholamine metabolism changes and hypothermia in intoxication by anticholinesterase agents.
Topics: alpha-Methyltyrosine; Animals; Brain; Catecholamines; Cholinesterase Inhibitors; Hypothalamus; Hypothermia; Male; Methyltyrosines; Paraoxon; Physostigmine; Rats; Rats, Inbred Strains; Soman | 1983 |
Influence of intoxication by anticholinesterase agents on core temperature in rats: relationships between hypothermia and acetylcholinesterase inhibition in different brain areas.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Cholinesterase Inhibitors; Male; Paraoxon; Physostigmine; Rats; Rats, Inbred Strains; Soman | 1981 |
The effects of pretreatments with carbamates, atropine and mecamylamine on survival and on soman-induced alterations in rat and rabbit brain acetylcholine.
Topics: Acetylcholine; Animals; Atropine; Benactyzine; Brain Chemistry; Carbamates; Male; Mecamylamine; Neostigmine; Organophosphorus Compounds; Physostigmine; Rabbits; Rats; Soman; Time Factors | 1980 |
Continuous administration of low dose rates of physostigmine and hyoscine to guinea-pigs prevents the toxicity and reduces the incapacitation produced by soman poisoning.
Topics: Acetylcholinesterase; Animals; Cerebellum; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Erythrocytes; Guinea Pigs; Hippocampus; Infusion Pumps, Implantable; Male; Medulla Oblongata; Mesencephalon; Osmosis; Physostigmine; Poisoning; Scopolamine; Soman | 1994 |
Behavioral toxicity of anticholinesterases in primates: effects of daily repeated soman exposure.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cholinesterases; Macaca mulatta; Male; Physostigmine; Postural Balance; Psychomotor Performance; Pyridostigmine Bromide; Soman | 1994 |
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Binding Sites; Brain; Cholinesterase Inhibitors; Injections, Intraperitoneal; Kinetics; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Physostigmine; Poisoning; Sesquiterpenes; Soman; Time Factors | 1994 |
Chromodacryorrhea in rats: absence following soman poisoning.
Topics: Acetylcholinesterase; Animals; Brain; Carbachol; Carboxylesterase; Carboxylic Ester Hydrolases; Harderian Gland; Lacrimal Apparatus Diseases; Male; Nicotine; Oxotremorine; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Rats, Sprague-Dawley; Soman | 1994 |
Behavioral toxicity of anticholinesterases in primates: chronic physostigmine and soman interactions.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cholinesterases; Drug Interactions; Injections, Subcutaneous; Macaca mulatta; Male; Physostigmine; Psychomotor Performance; Pyridostigmine Bromide; Soman | 1993 |
Efficacy of antidotes against soman poisoning in female physostigmine-protected rats.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Diazepam; Drug Therapy, Combination; Female; Muscles; Oximes; Physostigmine; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Soman | 1993 |
Efficacy of physostigmine as a pretreatment for organophosphate poisoning.
Topics: Animals; Cholinesterases; Lethal Dose 50; Male; Physostigmine; Poisoning; Rats; Rats, Sprague-Dawley; Soman | 1993 |
Pharmacological nature of soman-induced hypothermia in mice.
Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Hypothalamus; Hypothermia; Male; Mecamylamine; Mice; Nicotine; Obidoxime Chloride; Oximes; Oxotremorine; Physostigmine; Pyridinium Compounds; Soman | 1993 |
Mapping of cerebral metabolic activation in three models of cholinergic convulsions.
Topics: Animals; Autoradiography; Blood Pressure; Body Temperature; Brain Chemistry; Brain Mapping; Cholinesterase Inhibitors; Glucose; Parasympathetic Nervous System; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Soman | 1998 |
Subchronic physostigmine pretreatment in guinea pigs: effective against soman and without side effects.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Cholinesterase Inhibitors; Electroencephalography; Electrophysiology; Evoked Potentials, Visual; Guinea Pigs; Male; Muscarinic Antagonists; Physostigmine; Receptors, Cholinergic; Receptors, Muscarinic; Reflex, Startle; Scopolamine; Soman | 1998 |
Scopolamine augments the efficacy of physostigmine against soman poisoning in guinea pigs.
Topics: Animals; Cholinesterase Inhibitors; Drug Synergism; Electroencephalography; Guinea Pigs; Male; Muscarinic Antagonists; Physostigmine; Reflex, Startle; Scopolamine; Soman | 2000 |
Protection of mice against soman by pretreatment with eptastigmine and physostigmine.
Topics: Animals; Atropine; Blood-Brain Barrier; Brain; Cerebellum; Cholinesterase Inhibitors; Convulsants; Lethal Dose 50; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Physostigmine; Soman | 1999 |
Subchronic physostigmine pretreatment in marmosets: absence of side effects and effectiveness against soman poisoning with negligible postintoxication incapacitation.
Topics: Acetylcholine; Animals; Atropine; Avoidance Learning; Behavior, Animal; Callithrix; Cholinesterase Inhibitors; Electroencephalography; Electrophysiology; Evoked Potentials, Visual; Female; Lethal Dose 50; Male; Physostigmine; Reflex, Startle; Soman | 2000 |
Viral neuroinvasion as a marker for BBB integrity following exposure to cholinesterase inhibitors.
Topics: Alphavirus Infections; Animals; Blood-Brain Barrier; Brain; Central Nervous System Diseases; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Permeability; Physostigmine; Pyridostigmine Bromide; Sindbis Virus; Soman; Viremia | 2001 |
Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Male; Neuroprotective Agents; Physostigmine; Pyridostigmine Bromide; Scopolamine; Seizures; Sesquiterpenes; Soman; Time Factors | 2001 |
Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus).
Topics: Animals; Behavior, Animal; Callithrix; Cholinesterase Inhibitors; Discrimination Learning; Drug Implants; Drug Interactions; Female; Male; Muscarinic Antagonists; Organophosphorus Compounds; Physostigmine; Reversal Learning; Sarin; Scopolamine; Serial Learning; Soman | 2003 |
Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality.
Topics: Animals; Cognition Disorders; Drug Therapy, Combination; Exploratory Behavior; Lethal Dose 50; Male; Physostigmine; Procyclidine; Rats; Rats, Wistar; Scopolamine; Soman | 2004 |
Function of plasma and microsomal enzymes in soman toxicity.
Topics: Animals; Carboxylic Ester Hydrolases; Chemical Warfare Agents; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Enzymes; Inactivation, Metabolic; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Physostigmine; Soman | 2004 |
Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts.
Topics: Animals; Cholinesterase Inhibitors; Convulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Male; Muscarinic Antagonists; Neuroprotective Agents; Physostigmine; Procyclidine; Rats; Rats, Wistar; Scopolamine; Seizures; Soman | 2004 |
Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats.
Topics: Animals; Avoidance Learning; Blood-Brain Barrier; Brain; Capillary Permeability; Cholinesterase Inhibitors; Delayed-Action Preparations; Dose-Response Relationship, Drug; Infusion Pumps; Male; Memory; Muscarinic Antagonists; Physostigmine; Procyclidine; Rats; Rats, Sprague-Dawley; Seizures; Soman; Specific Pathogen-Free Organisms; Time Factors | 2004 |
Stress adversely affects efficacy of physostigmine-scopolamine pretreatment against soman in guinea pigs.
Topics: Animals; Chemical Warfare Agents; Drug Combinations; Electroencephalography; Guinea Pigs; Physostigmine; Reflex, Startle; Scopolamine; Soman; Stress, Physiological | 2005 |
Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs.
Topics: Administration, Cutaneous; Animals; Atropine; Cholinesterase Inhibitors; Dogs; Female; Muscarinic Antagonists; Neuroprotective Agents; Oximes; Physostigmine; Procyclidine; Pyridinium Compounds; Soman | 2005 |
Development of next generation medical countermeasures to nerve agent poisoning.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Dipeptides; Disease Models, Animal; Drug Therapy, Combination; Guinea Pigs; Ileal Diseases; Intussusception; Lethal Dose 50; Male; Neurotoxicity Syndromes; Oximes; Physostigmine; Pyridinium Compounds; Scopolamine Derivatives; Soman; Time Factors | 2007 |
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors.
Topics: Acetylcholinesterase; Carbamates; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Erythrocytes; Humans; Kinetics; Muscle, Skeletal; Physostigmine; Pyridostigmine Bromide; Soman | 2008 |
Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?
Topics: Animals; Atropine; Brain; Carbamates; Chemical Warfare Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Male; Models, Animal; Obidoxime Chloride; Parasympatholytics; Physostigmine; Seizures; Soman; Time Factors; Treatment Outcome | 2011 |
Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Intercostal Muscles; Physostigmine; Soman; Time Factors; Treatment Outcome | 2011 |
In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species.
Topics: Acetylcholinesterase; Animals; Carbamates; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Erythrocytes; Female; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Macaca mulatta; Male; Muscle, Skeletal; Physostigmine; Pyridostigmine Bromide; Soman; Species Specificity; Swine | 2011 |
Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Muscarinic Antagonists; Oximes; Physostigmine; Poisoning; Procyclidine; Pyridinium Compounds; Soman; Transdermal Patch | 2012 |
Determination of anti-convulsant and life-preserving capacities of three types of auto-injector therapies against soman intoxication in rats.
Topics: Animals; Antidotes; Atropine; Benzodiazepines; Cholinesterase Inhibitors; Convulsants; Male; Oximes; Physostigmine; Rats; Rats, Wistar; Scopolamine; Seizures; Soman | 2013 |
Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility.
Topics: Animals; Anticonvulsants; Male; Neuroprotective Agents; Physostigmine; Procyclidine; Rats; Rats, Wistar; Seizures; Soman; Time Factors; Treatment Outcome | 2013 |
(-)-Phenserine attenuates soman-induced neuropathology.
Topics: Animals; Carrier Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Gene Expression Regulation; Homer Scaffolding Proteins; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus | 2014 |