Page last updated: 2024-08-18

soman and asoxime chloride

soman has been researched along with asoxime chloride in 133 studies

Research

Studies (133)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (24.81)	18.7374
1990's	54 (40.60)	18.2507
2000's	21 (15.79)	29.6817
2010's	25 (18.80)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A	1
Anderson, DR; Harris, LW; Lennox, WJ; Woodard, CL	1
Karlsson, N; Larsson, R; Puu, G	1
Boulet, CA; Clement, JG; Hansen, AS	1
Koplovitz, I; Stewart, JR	2
Holmstedt, B; Karlén, B; Kimland, M; Nordgren, I; Palmér, L	1
Busker, RW; de Lange, J; Melchers, BP; van der Wiel, HJ; van Helden, HP; Wolthuis, OL	1
Capacio, BR; Koviak, TA; Shih, TM	1
Bessette, E; Clement, JG; Erhardt, N; Rosario, S	1
Hamilton, MG; Posavad, C	1
Shih, T; Valdes, JJ; Whalley, CE	1
Brecht, KM; Maxwell, DM	1
Demerseman, P; Garrigue, H; Godeneche, D; Hulot, T; Madelmont, JC; Maurizis, JC; Morge, X; Nicolas, C; Sentenac-Roumanou, H; Veyre, A	1
Anderson, DR; Harris, LW; Lennox, WJ; Pastelak, AM; Vanderpool, BA; Woodard, CL	1
Shih, TM	2
Koplovitz, I; Maxwell, DM	1
Broxup, BR; Hamilton, MG; Hand, BT; Lundy, PM; Yipchuck, G	1
Anthony, A; Doebler, JA; Martin, LJ	1
Bosković, B; Krtolica, K; Marinković, S; Poznanović, G; Sevaljević, L	1
Brzin, M; Dekleva, A; Sket, D; Sketelj, J	1
Goulet, JC; Hand, BT; Lundy, PM	1
Hamilton, MG; Lundy, PM	1
Grubic, Z; Tomazic, A	1
van der Wiel, HJ; Van Helden, HP; Wolthuis, OL	3
Xu, XS; Yuan, BL	1
Arbogast, H; Auburger, G; Hallek, M; Reithmann, C; Szinicz, L	1
Clement, JG; Gennings, C; Shiloff, JD	1
Pantelić, D	1
Artursson, E; Bucht, G; Puu, G	1
Chou, TC; Li, FZ; Sun, MC	1
Brzin, M; Sket, D	1
de Jong, LP; Kossen, SP	1
Algers, G; Karlsson, B; Sellström, A	1
Anthony, A; Doebler, JA; Martin, LJ; Shih, TM; Wall, TJ	1
Smith, AP; Wolthuis, OL	1
Benschop, HP; Van Helden, HP; Wolthuis, OL	1
Van der Wiel, HJ; Vanwersch, RA; Wolthuis, O	1
Smith, AP; Van der Wiel, HJ; Wolthuis, OL	1
Van Helden, HP; Wolthuis, OL	1
De Bisschop, HC; Nicaise, M; Willems, JL	1
Bosković, B; Jovanović, D; Kovacević, V	1
Lundy, PM; Shih, TM	1
Fonnum, F; Lyngaas, S; Sterri, SH	1
Clement, JG	2
Clement, JG; Lockwood, PA	1
Benschop, HP; Berends, F; Wolthuis, OL	1
de Jong, LP; Wolring, GZ	1
Dola, T; Lipp, J	1
Kassa, J	7
Clement, JG; Erhardt, N	1
Melchers, BP; Philippens, IH; Wolthuis, OL	1
Doctor, BP; Lenz, DE; Maxwell, DM; Radic, Z; Saxena, A; Taylor, P	1
Busker, RW; van der Wiel, HJ; van Helden, HP; Zijlstra, JJ	1
Lau, WM	1
Adler, M; Deshpande, SS; Filbert, MG; Maxwell, DM	1
Ashani, Y; Asher, JM; Brecht, KM; Caranto, GR; Larrison, RW; Maxwell, DM; Raveh, L; Schutz, MB; Waibel, KH; Wolfe, AD	1
Brank, M; Grubic, Z; Sentjurc, M; Stalc, A	1
Szinicz, L; Worek, F	1
Sket, D	1
Brecht, KM; Doctor, BP; Maxwell, DM; Wolfe, AD	1
Aas, P; Fonnum, F; Haider, T; Walday, P	1
Ivanović-Matić, S; Poznanović, G	1
Bajgar, J; Kassa, J	4
Hallek, M; Szinicz, L	1
Cassel, G; Göransson-Nyberg, A; Jeneskog, T; Karlsson, L; Larsson, R; Lundström, M; Persson, SA	1
Aas, P	1
Cassel, GE; Fosbraey, P	1
Busker, RW; Groen, B; Melchers, BP; Philippens, IH; Zijlstra, JJ	1
Bruijnzeel, PL; Busker, RW; Melchers, BP; van Helden, HP	1
Baubichon, D; Blanchet, G; Brochier, G; Clarencon, D; Galonnier, M; Lallement, G; Mestries, JC	1
Kassa, J; Vachek, J	1
Ang, KW; Cassel, G; Göransson-Nyberg, A; Karlsson, L; Waara, L	1
Fusek, J; Kassa, J	2
Knopff, O; Szinicz, L; Widmann, R; Worek, F	1
Koplovitz, I; Skvorak, JP	1
Cassel, G; Göransson-Nyberg, A	1
Kassa, J; Krejcová, G; Samnaliev, I	1
Kassa, J; Samnaliev, I	1
Berger, BJ; Davidson, C; Hamilton, MG; Hill, I; Lecavalier, P; Lundy, PM; Vair, C; Weatherby, KL	1
Cassel, G; Svensson, I; Waara, L	1
Aas, P; Tansø, R; Øydvin, OK	1
Li, JX; Liu, KL; Liu, YQ; Ruan, JX; Wang, YA; Yue, YJ; Zheng, JQ; Zhou, WX	1
Go, ML; Loke, WK; Sim, MK	1
Cho, Y; Choi, EK; Huang, ZZ; Hwang, SY; Kang, JK; Kim, JC; Kim, WS; Kim, YB; Nam, SY; Park, SH; Shin, S	1
Aas, P; Enger, S; Myhrer, T	1
Reiner, E; Simeon-Rudolf, V	1
Armstrong, S; Mumford, H; Price, M; Scott, L; Wetherell, J	1
Bajgar, J; Jun, D; Kuca, K	1
Baille, V; Carpentier, P; Dorandeu, F; Lallement, G; Mikler, J; Sawyer, T; Testylier, G	1
Karasova, J; Kassa, J	1
Bajgar, J; Jun, D; Kassa, J; Kuca, K	1
Joosen, MJ; Jousma, E; Kuijpers, WC; Lucassen, PJ; Smit, AB; van den Boom, TM; van Helden, HP	1
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J	1
Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S	1
Baati, R; Gillon, E; Jean, L; Mercey, G; Nachon, F; Renard, PY; Saint-André, G; Verdelet, T; Wagner, A	1
Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW	1
Joosen, MJ; Kuijpers, WC; van der Schans, MJ; van Dijk, CG; van Helden, HP; Wortelboer, HM	1
Karasova, JZ; Kassa, J; Tesarova, S	1
Bumm, R; Friess, H; Gerhardus, J; Langer, P; Mihaljevic, AL; Niessen, KV; Seeger, T; Thiermann, H; Worek, F	1
Kassa, J; Kuca, K; Pikula, J; Pohanka, M	1
Bhattacharya, BK; Kumar, S; RamaRao, G; Waghmare, CK	1
Bajgar, J; Kassa, J; Koomlova, M; Musilek, K	1
Cho, Y; Ha, YC; Hur, GH; Kim, WS	1
Antonijević, B; Bokonjić, D; Stojiljković, MP; Vucinić, S	1
Dimov, D; Dimova, I; Kanev, K	1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Green, CE; Qashu, F; Swezey, R; Yang, C	1
Aas, P; Enger, S; Mariussen, E; Myhrer, T	2
Acharya, J; Afley, P; Bhattacharya, BK; RamaRao, G	1
Fokin, VV; Katalinić, M; Kovarik, Z; Maček Hrvat, N; Musilek, K; Paradyse, A; Radić, Z; Sit, RK; Taylor, P; Žunec, S	1
Apland, JP; Chen, J; Grunberg, N; Marini, AM; McDonough, J; Pan, H; Piermartiri, TC	1
Fan, L; Li, W; Luo, Y; Sui, X; Wang, F; Wang, Y; Yang, J; Zhang, X	1
Huang, CQ; Li, S; Li, WH; Li, XZ; Liu, J; Liu, YQ; Wang, YA; Wei, Z; Zhao, J; Zheng, ZB; Zhou, XB	1
Hamelink, J; Joosen, MJA; Klaassen, SD; van den Berg, RM; Vester, SM	1
Thiermann, H; Wille, T; Worek, F	1
Green, AC; Price, ME; Rice, H; Tattersall, JEH; Whitmore, CL	1
Cornelissen, AS; Hesseling, P; Joosen, MJA; Klaassen, SD; Lucassen, PJ; Meerhoff, GF; Vester, SM	1
Bokonjić, D; Jokanović, M; Kilibarda, V; Škrbić, R; Stojiljković, MP; Vulović, M	1

Reviews

2 review(s) available for soman and asoxime chloride

Article	Year
Pharmacological effects of oximes: how relevant are they? Archives of toxicology, 1996, Volume: 70, Issue:12 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Organophosphate Poisoning; Organophosphates; Oximes; Poisoning; Pyridinium Compounds; Receptors, Cholinergic; Respiration; Soman; Synaptic Transmission	1996
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning. Toxicology, 2011, Jul-29, Volume: 285, Issue:3 Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman	2011

Other Studies

131 other study(ies) available for soman and asoxime chloride

Article	Year
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine	2008
The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats. Drug and chemical toxicology, 1992, Volume: 15, Issue:4 Topics: Animals; Antidotes; Cholinesterase Inhibitors; Male; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Soman	1992
Protection of guinea pigs against soman poisoning with ferrocene carbamate. Archives of toxicology, 1992, Volume: 66, Issue:9 Topics: Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Ferrous Compounds; Guinea Pigs; Lethal Dose 50; Male; Metallocenes; Organometallic Compounds; Oximes; Physostigmine; Pyridinium Compounds; Soman	1992
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Archives of toxicology, 1992, Volume: 66, Issue:3 Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman	1992
Efficacy of oxime plus atropine treatment against soman poisoning in the atropinesterase-free rabbit. Drug and chemical toxicology, 1992, Volume: 15, Issue:2 Topics: Animals; Antidotes; Drug Therapy, Combination; Lethal Dose 50; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Soman	1992
Intoxications with anticholinesterases: effect of different combinations of antidotes on the dynamics of acetylcholine in mouse brain. Pharmacology & toxicology, 1992, Volume: 70, Issue:5 Pt 1 Topics: Acetylcholine; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Drug Therapy, Combination; Male; Mice; Oximes; Poisoning; Pyridinium Compounds; Soman	1992
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys. Toxicology and applied pharmacology, 1992, Volume: 115, Issue:1 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Butyrylcholinesterase; Callithrix; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Diaphragm; Diazepam; Enzyme Activation; Oximes; Poisoning; Pyridinium Compounds; Soman	1992
Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neuroscience and biobehavioral reviews, 1991,Fall, Volume: 15, Issue:3 Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Atropine; Brain Chemistry; Choline; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Gas Chromatography-Mass Spectrometry; Male; Oximes; Parasympatholytics; Poisoning; Pyridinium Compounds; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Seizures; Soman	1991
Soman and sarin inhibition of molecular forms of acetylcholinesterase in mice. Time course of recovery and reactivation by the oxime HI-6. Biochemical pharmacology, 1991, Jul-05, Volume: 42, Issue:2 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Hypothalamus; Isoenzymes; Male; Mice; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors	1991
Alteration of calcium influx in rat cortical synaptosomes by soman. Neuroreport, 1991, Volume: 2, Issue:5 Topics: Animals; Calcium; Cerebral Cortex; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Oximes; Potassium Chloride; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Synaptosomes	1991
A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning. Toxicology letters, 1991, Volume: 55, Issue:2 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Drug Interactions; Lethal Dose 50; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Soman	1991
The role of carboxylesterase in species variation of oxime protection against soman. Neuroscience and biobehavioral reviews, 1991,Spring, Volume: 15, Issue:1 Topics: Animals; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Soman; Species Specificity	1991
Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning. Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:7 Topics: Acetylcholinesterase; Animals; Carbon Radioisotopes; Cartilage; Cholinesterase Reactivators; Feces; Glycosaminoglycans; Half-Life; Imidazoles; Intervertebral Disc; Kidney; Male; Molecular Structure; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Tissue Distribution	1990
Evaluation of several oximes as reactivators of unaged soman-inhibited whole blood acetylcholinesterase in rabbits. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Acetylcholinesterase; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Diaphragm; Dose-Response Relationship, Drug; Imidazoles; Medulla Oblongata; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rabbits; Soman; Time Factors	1990
Anticonvulsant effects of diazepam and MK-801 in soman poisoning. Epilepsy research, 1990, Volume: 7, Issue:2 Topics: Animals; Anticonvulsants; Antidotes; Atropine; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Oximes; Pyridinium Compounds; Rats; Soman	1990
Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2 Topics: Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Injections, Intramuscular; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Oximes; Pyridinium Compounds; Soman; Species Specificity	1990
Distribution of the bispyridinium oxime [14C] HI-6 in male and female rats. Archives of toxicology, 1990, Volume: 64, Issue:5 Topics: Animals; Antidotes; Atropine; Autoradiography; Female; Male; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sex Factors; Soman; Tissue Distribution	1990
Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites. Journal of the neurological sciences, 1985, Volume: 71, Issue:1 Topics: Animals; Antidotes; Cholinesterase Reactivators; Cholinesterases; Corpus Striatum; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA; Soman; Thalamic Nuclei	1985
Soman intoxication-induced increase in the levels of mRNAs coding for acute phase reactants. Life sciences, 1987, Aug-03, Volume: 41, Issue:5 Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Antidotes; Atropine; Liver; Male; Nucleic Acid Hybridization; Oximes; Protein Biosynthesis; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA, Messenger; Serum Albumin; Soman; Turpentine	1987
Attenuation of soman-induced lesions of skeletal muscle by acetylcholinesterase reactivating and non-reactivating antidotes. Acta neuropathologica, 1989, Volume: 79, Issue:2 Topics: Acetylcholinesterase; Animals; Antidotes; Male; Muscles; Organophosphate Poisoning; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman	1989
Hormone- and dose schedule-dependent protection by HI-6 against soman and tabun poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 12, Issue:3 Topics: Animals; Body Weight; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Male; Obidoxime Chloride; Orchiectomy; Organophosphates; Organophosphorus Compounds; Ovariectomy; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Species Specificity; Testosterone; Time Factors	1989
HI-6 therapy of soman and tabun poisoning in primates and rodents. Archives of toxicology, 1989, Volume: 63, Issue:2 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Respiratory Muscles; Soman	1989
Mechanism of action of HI-6 on soman inhibition of acetylcholinesterase in preparations of rat and human skeletal muscle; comparison to SAD-128 and PAM-2. Archives of toxicology, 1989, Volume: 63, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Female; Humans; In Vitro Techniques; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman	1989
Prophylactic and therapeutic efficacy of the soman-simulator, pinacolyl dimethylphosphinate. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:6 Topics: Animals; Antidotes; Atropine; Injections, Intravenous; Lethal Dose 50; Male; Neuromuscular Junction; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Synaptic Transmission; Time Factors	1986
Retention of soman in rats, guinea-pigs and marmosets: species-dependent effects of the soman simulator, pinacolyl dimethylphosphinate (PDP). The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Callitrichinae; Electrophorus; Female; Guinea Pigs; Male; Muscles; Oximes; Pyridinium Compounds; Soman; Species Specificity	1988
[Antagonistic effects of 6 drugs on myopathy induced by soman intoxication]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:2 Topics: Animals; Cholinesterase Reactivators; Female; Gallamine Triethiodide; Muscular Diseases; Neomycin; Neuromuscular Junction; Oximes; Pyridinium Compounds; Rats; Soman	1988
Studies on the role of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice. Archives of toxicology, 1988, Volume: 62, Issue:1 Topics: Animals; Antidotes; Atropine; Brain Chemistry; Catecholamines; Cholinesterases; Male; Mice; Mice, Inbred Strains; Motor Activity; Oximes; Pyridinium Compounds; Soman	1988
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice. Archives of toxicology, 1987, Volume: 61, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman	1987
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare]. Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28 Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman	1986
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime. Biochemical pharmacology, 1986, May-01, Volume: 35, Issue:9 Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism	1986
Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes. Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Reactivators; Erythrocytes; Humans; Muscles; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman	1986
Effect of HI-6, applied into the cerebral ventricles, on the inhibition of brain acetylcholinesterase by soman in rats. Neuropharmacology, 1986, Volume: 25, Issue:1 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Reactivators; Injections, Intraventricular; Male; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman	1986
Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2-trimethylpropyl methylphosphonofluoridate (soman). Biochimica et biophysica acta, 1985, Aug-23, Volume: 830, Issue:3 Topics: Acetylcholinesterase; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Kinetics; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman; Stereoisomerism	1985
Soman intoxication and the blood-brain barrier. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:6 Pt 2 Topics: Acetylcholinesterase; Animals; Blood-Brain Barrier; Brain; Capillaries; Cerebrovascular Circulation; In Vitro Techniques; Male; Monoamine Oxidase; Muscle, Smooth, Vascular; Oximes; Pyridinium Compounds; Rabbits; Soman; Time Factors	1985
Effects of HI-6 on brain neuronal RNA and acetylcholinesterase: metabolic responses during acute soman intoxication. Toxicology, 1984, Volume: 33, Issue:3-4 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cerebral Cortex; Cholinesterases; Corpus Striatum; Drug Interactions; Male; Neurons; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA; Soman	1984
HI6 as an antidote to soman poisoning in rhesus monkey respiratory muscles in-vitro. The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:3 Topics: Animals; Antidotes; Cholinesterase Inhibitors; Female; Intercostal Muscles; Macaca mulatta; Male; Muscle Contraction; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman	1983
New simulators in the prophylaxis against soman poisoning: structural specificity for the depot site(s). The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:5 Topics: Animals; Antidotes; Atropine; Chemical Phenomena; Chemistry, Physical; Male; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Structure-Activity Relationship; Synaptic Transmission	1984
The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man. European journal of pharmacology, 1981, Mar-26, Volume: 70, Issue:3 Topics: Adult; Aged; Animals; Antidotes; Chorionic Gonadotropin; Dogs; Electric Stimulation; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Sarin; Soman; Species Specificity; Synaptic Transmission	1981
Analysis of oxime-induced neuromuscular recovery in guinea pig, rat and man following soman poisoning in vitro. European journal of pharmacology, 1981, Mar-26, Volume: 70, Issue:3 Topics: Aged; Animals; Diaphragm; Guinea Pigs; Humans; In Vitro Techniques; Intercostal Muscles; Male; Middle Aged; Neuromuscular Junction; Organ Specificity; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity; Synaptic Transmission; Time Factors	1981
Therapy of organophosphate poisoning: the marmoset as a model for man. British journal of pharmacology, 1983, Volume: 78, Issue:3 Topics: Animals; Antidotes; Callithrix; Cardiovascular System; Humans; In Vitro Techniques; Insecticides; Models, Biological; Neuromuscular Junction; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Soman; Synaptic Transmission	1983
Evidence for an intramuscular depot of the cholinesterase inhibitor soman in the rat. European journal of pharmacology, 1983, May-06, Volume: 89, Issue:3-4 Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Male; Muscles; Neuromuscular Junction; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Synaptic Transmission	1983
Delayed neuropathy by the organophosphorus nerve agents soman and tabun. Archives of toxicology, 1984, Volume: 55, Issue:1 Topics: Animals; Chickens; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Lethal Dose 50; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nervous System Diseases; Pyridinium Compounds; Soman	1984
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity	1984
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning. Journal of neurochemistry, 1983, Volume: 40, Issue:5 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Injections, Intraventricular; Lethal Dose 50; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman	1983
Cholinesterase and carboxylesterase activities in soman poisoned rats treated with bispyridinium mono-oximes HI-6 and HS-6. Biochemical pharmacology, 1983, May-15, Volume: 32, Issue:10 Topics: Animals; Antidotes; Carboxylic Ester Hydrolases; Cholinesterases; Male; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Tritolyl Phosphates	1983
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat. Biochemical pharmacology, 1982, Apr-01, Volume: 31, Issue:7 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nerves; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman	1982
HI-6, an oxime which is an effective antidote of soman poisoning: a structure-activity study. Toxicology and applied pharmacology, 1982, Jun-15, Volume: 64, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterases; Male; Mice; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Soman; Structure-Activity Relationship	1982
Persistence of the anti-cholinesterase soman in rats; antagonism with a non-toxic simulator of this organophosphate. European journal of pharmacology, 1981, Jan-29, Volume: 69, Issue:3 Topics: Acetylcholinesterase; Animals; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Soman; Time Factors	1981
Reactivation of acetylcholinesterase inhibited by 1,2,2'-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. Biochemical pharmacology, 1980, Sep-01, Volume: 29, Issue:17 Topics: Acetylcholinesterase; Animals; Cattle; Cholinesterase Reactivators; Erythrocytes; Kinetics; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman	1980
comparison of the efficacy of HS-6 versus HI-6 when combined with atropine, pyridostigmine and clonazepam for soman poisoning in the monkey. Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 246, Issue:1 Topics: Animals; Atropine; Cholinesterases; Clonazepam; Electroencephalography; Female; Heart Rate; Macaca mulatta; Male; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Respiration; Soman	1980
Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats. Toxicology, 1995, Aug-25, Volume: 101, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Reactivators; Cortisone; Female; Liver; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase	1995
In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human. Archives of toxicology, 1994, Volume: 68, Issue:10 Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Humans; In Vitro Techniques; Macaca fascicularis; Male; Muscle, Skeletal; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Soman; Species Specificity; Tissue Preservation	1994
Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4 Topics: Animals; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Conditioning, Operant; Electroencephalography; Guinea Pigs; Lethal Dose 50; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiratory Mechanics; Soman	1994
The role of glutamate-199 in the aging of cholinesterase. Biochemical and biophysical research communications, 1993, Nov-30, Volume: 197, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Mutation; Oximes; Pyridinium Compounds; Soman; Titrimetry; Torpedo	1993
The functional role of molecular forms of acetylcholinesterase in neuromuscular transmission. Neurochemical research, 1994, Volume: 19, Issue:6 Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Isoenzymes; Kinetics; Male; Neuromuscular Junction; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Synaptic Transmission	1994
Protection by tacrine and some adjuncts against the depressant effects of soman in guinea-pig atrium. General pharmacology, 1993, Volume: 24, Issue:6 Topics: Animals; Atropine; Cholinesterase Reactivators; Female; Glycopyrrolate; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Oximes; Parasympatholytics; Pyridinium Compounds; Soman; Tacrine	1993
Contribution of direct actions of the oxime HI-6 in reversing soman-induced muscle weakness in the rat diaphragm. European journal of pharmacology, 1994, Jan-03, Volume: 270, Issue:1 Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Diaphragm; Electrophysiology; In Vitro Techniques; Male; Muscle Contraction; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Soman	1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit. Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms	1994
Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes. Biochemical pharmacology, 1994, Jan-20, Volume: 47, Issue:2 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Inactivation, Metabolic; Lethal Dose 50; Mice; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman	1994
Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats. Archives of toxicology, 1993, Volume: 67, Issue:9 Topics: Animals; Antidotes; Brain; Cholinesterase Reactivators; Cholinesterases; Enzyme Activation; Heart; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Soman; Tissue Distribution	1993
The influence of soman simulator on reactivation by HI-6 of soman-inhibited acetylcholinesterase in preparations of rat and human skeletal muscle. Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2 Topics: Acetylcholine; Animals; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Electron Spin Resonance Spectroscopy; Electrophorus; Humans; In Vitro Techniques; Models, Biological; Motor Endplate; Muscles; Oximes; Phosphorylation; Pyridinium Compounds; Rats; Soman	1993
Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethanesulfonate versus HI 6 dichloride. Pharmacology & toxicology, 1993, Volume: 72, Issue:1 Topics: Acetylcholinesterase; Anesthesia; Animals; Antidotes; Atropine; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Erythrocytes; Female; Guinea Pigs; Hemodynamics; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration; Soman	1993
Efficacy of antidotes against soman poisoning in female physostigmine-protected rats. Pharmacology & toxicology, 1993, Volume: 72, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Diazepam; Drug Therapy, Combination; Female; Muscles; Oximes; Physostigmine; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1993
Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesterase. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Male; Mice; Mice, Inbred ICR; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Soman	1993
Pharmacological nature of soman-induced hypothermia in mice. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3 Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Hypothalamus; Hypothermia; Male; Mecamylamine; Mice; Nicotine; Obidoxime Chloride; Oximes; Oxotremorine; Physostigmine; Pyridinium Compounds; Soman	1993
Effect of pyridostigmine pretreatment, HI-6 and Toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure. Archives of toxicology, 1993, Volume: 67, Issue:3 Topics: Administration, Inhalation; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electric Stimulation; Male; Muscle Contraction; Muscle, Smooth; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trachea	1993
HI-6 therapy and the acute phase response in the rat. Toxicology, 1996, Jan-08, Volume: 106, Issue:1-3 Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Antidotes; Atropine; Blood Proteins; Blotting, Northern; Corticosterone; Immunoelectrophoresis; Injections, Intraperitoneal; Liver; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; RNA, Messenger; Soman; Turpentine	1996
[Comparison of the effect of HI-6 oxime and its derivatives in combination with benactyzine on cholinergic and stress effects of soman in rats]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1996, Volume: 45, Issue:3 Topics: Animals; Antidotes; Benactyzine; Cholinesterase Inhibitors; Cholinesterases; Corticosterone; Drug Therapy, Combination; Male; Oximes; Parasympatholytics; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase	1996
The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats. Human & experimental toxicology, 1996, Volume: 15, Issue:5 Topics: Animals; Antidotes; Benactyzine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Corticosterone; Diaphragm; Drug Therapy, Combination; Liver; Male; Muscarinic Antagonists; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trihexyphenidyl; Tyrosine Transaminase	1996
Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro. Archives of toxicology, 1995, Volume: 70, Issue:1 Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Interactions; Enzyme Activation; Erythrocytes; Humans; Kinetics; Methantheline; Oximes; Pyridinium Compounds; Quaternary Ammonium Compounds; Soman	1995
Treatment of organophosphate poisoning in pigs: antidote administration by a new binary autoinjector. Archives of toxicology, 1995, Volume: 70, Issue:1 Topics: Animals; Antidotes; Atropine; Drug Combinations; Injections, Intramuscular; Injections, Jet; Male; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman; Swine	1995
In vitro effects of toxogonin, HI-6 and HLö-7 on the release of [3H]acetylcholine from peripheral cholinergic nerves in rat airway smooth muscle. European journal of pharmacology, 1996, Apr-22, Volume: 301, Issue:1-3 Topics: Acetylcholine; Acetylcholinesterase; Animals; Bronchi; Butyrylcholinesterase; Calcium Channel Blockers; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Male; Muscle, Smooth; Obidoxime Chloride; Oximes; Parasympathetic Nervous System; Peripheral Nerves; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1996
Measurement of the oxime HI-6 after peripheral administration in tandem with neurotransmitter levels in striatal dialysates: effects of soman intoxication. Journal of pharmacological and toxicological methods, 1996, Volume: 35, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Neurotransmitter Agents; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1996
Comparison of the efficacy of single or repeated HI-6 treatment following soman poisoning in guinea pigs and marmoset monkeys. Toxicology, 1996, Sep-02, Volume: 112, Issue:3 Topics: Animals; Antidotes; Area Under Curve; Atropine; Avoidance Learning; Behavior, Animal; Callithrix; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Electroencephalography; Female; Guinea Pigs; Half-Life; Injections, Intramuscular; Injections, Subcutaneous; Lethal Dose 50; Male; Muscarinic Antagonists; Neurophysiology; Oximes; Pyridinium Compounds; Soman	1996
Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats. Toxicology, 1997, Jan-15, Volume: 116, Issue:1-3 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Benactyzine; Biperiden; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corticosterone; Diaphragm; Drug Interactions; Liver; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Stress, Physiological; Tyrosine Transaminase	1997
Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2 Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Macaca fascicularis; Male; Oximes; Poisoning; Pralidoxime Compounds; Prodrugs; Pyridinium Compounds; Soman	1997
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice. Acta medica (Hradec Kralove), 1996, Volume: 39, Issue:1 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman	1996
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice]. Casopis lekaru ceskych, 1997, Feb-12, Volume: 136, Issue:4 Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman	1997
Pharmacokinetics and effects of HI 6 in blood and brain of soman-intoxicated rats: a microdialysis study. European journal of pharmacology, 1997, Jul-30, Volume: 332, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dopamine; Enzyme Activation; Male; Microdialysis; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1997
Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats. Human & experimental toxicology, 1997, Volume: 16, Issue:10 Topics: Acetylcholinesterase; Animals; Antidotes; Benactyzine; Blood Pressure; Brain; Central Nervous System Diseases; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Drug Therapy, Combination; Electrocardiography; Heart Rate; Male; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Respiration; Soman; Trihexyphenidyl	1997
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Archives of toxicology, 1998, Volume: 72, Issue:4 Topics: Acetylcholinesterase; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Soman	1998
Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats. Epilepsy research, 1998, Volume: 30, Issue:2 Topics: Animals; Cholinesterase Reactivators; Convulsants; Electroencephalography; Male; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus	1998
Changes of acetylcholinesterase activity in various parts of brain following nontreated and treated soman poisoning in rats. Molecular and chemical neuropathology, 1998, Volume: 33, Issue:3 Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1998
[The effect of pharmacologic prophylaxis with Panpal on acetylcholinesterase activity in the diaphragm and various parts of the brain in rats during treated and untreated Soman poisoning]. Casopis lekaru ceskych, 1998, May-18, Volume: 137, Issue:10 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Benactyzine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Drug Combinations; Male; Oximes; Poisoning; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trihexyphenidyl	1998
A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats. Human & experimental toxicology, 1998, Volume: 17, Issue:6 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Liver; Male; Obidoxime Chloride; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase	1998
[Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1999, Volume: 48, Issue:1 Topics: Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Pyridinium Compounds; Soman	1999
[Comparison of the reactivating effect of BI-6, a new asymmetrical bispyridinium oxime, with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats]. Casopis lekaru ceskych, 1999, Aug-30, Volume: 138, Issue:17 Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Male; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1999
The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats. Toxicology, 2000, Nov-23, Volume: 154, Issue:1-3 Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Blood Pressure; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electrocardiography; Heart Rate; Male; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Scopolamine; Soman	2000
[Effect of diazepam on the effectiveness of antidote therapy in eliminating the acute lethal effects of soman in mice]. Casopis lekaru ceskych, 2001, Volume: 140, Issue:16 Topics: Acute Disease; Animals; Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Male; Mice; Mice, Inbred Strains; Oximes; Poisoning; Pyridinium Compounds; Soman	2001
Cardiopulmonary effects of HI-6 treatment in soman intoxication. Journal of applied toxicology : JAT, 2001, Volume: 21 Suppl 1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Blood Pressure; Chemical Warfare Agents; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Regional Blood Flow; Respiration; Soman	2001
A comparison of the neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in soman-poisoned rats. Acta medica (Hradec Kralove), 2003, Volume: 46, Issue:3 Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Drug Therapy, Combination; Male; Neuroprotective Agents; Oximes; Premedication; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trihexyphenidyl	2003
Assessment of the therapeutic and anticonvulsive efficacy of a drug combination consisting of trihexyphenidyle and HI-6 in soman-poisoned rats. Acta medica (Hradec Kralove), 2004, Volume: 47, Issue:3 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Convulsants; Drug Therapy, Combination; Male; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Trihexyphenidyl	2004
The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning. Toxicology, 2005, Mar-30, Volume: 208, Issue:3 Topics: Animals; Atropine; Chemical Warfare Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neuroprotective Agents; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman; Swine; Time Factors	2005
Effects of HI 6, diazepam and atropine on soman-induced IL-1 beta protein in rat brain. Neurotoxicology, 2005, Volume: 26, Issue:2 Topics: Animals; Atropine; Brain; Diazepam; Drug Therapy, Combination; Electroencephalography; Interleukin-1; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman	2005
Pre-junctional effects of oximes on [3H]-acetylcholine release in rat hippocampal slices during soman intoxication. European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3 Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Oximes; Potassium; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tritium	2005
Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms. Life sciences, 2005, Nov-26, Volume: 78, Issue:2 Topics: Animals; Anticonvulsants; Aza Compounds; Behavior, Animal; Brain Chemistry; Cells, Cultured; Cholinergic Antagonists; Cholinesterase Inhibitors; Convulsants; Electroencephalography; Excitatory Amino Acid Agonists; Female; Glycolates; Hippocampus; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Oximes; Parasympathetic Nervous System; Pentylenetetrazole; Pyridinium Compounds; Quinuclidines; Rats; Rats, Wistar; Seizures; Soman	2005
Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents. European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Atropine; Benzene Derivatives; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corpus Striatum; Dopamine; Drug Synergism; Electroencephalography; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Mice; Microdialysis; Neuroprotective Agents; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Serotonin; Soman; Survival Rate; Time Factors	2005
Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs. European journal of pharmacology, 2005, Nov-21, Volume: 525, Issue:1-3 Topics: Administration, Cutaneous; Animals; Atropine; Cholinesterase Inhibitors; Dogs; Female; Muscarinic Antagonists; Neuroprotective Agents; Oximes; Physostigmine; Procyclidine; Pyridinium Compounds; Soman	2005
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2 Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Dipeptides; Drug Combinations; Lethal Dose 50; Male; Oximes; Pentobarbital; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman	2006
Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman. Arhiv za higijenu rada i toksikologiju, 2006, Volume: 57, Issue:2 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Trimedoxime	2006
Development of next generation medical countermeasures to nerve agent poisoning. Toxicology, 2007, Apr-20, Volume: 233, Issue:1-3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Dipeptides; Disease Models, Animal; Drug Therapy, Combination; Guinea Pigs; Ileal Diseases; Intussusception; Lethal Dose 50; Male; Neurotoxicity Syndromes; Oximes; Physostigmine; Pyridinium Compounds; Scopolamine Derivatives; Soman; Time Factors	2007
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug and chemical toxicology, 2007, Volume: 30, Issue:1 Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime	2007
Protective effects of S+ ketamine and atropine against lethality and brain damage during soman-induced status epilepticus in guinea-pigs. Toxicology, 2007, May-20, Volume: 234, Issue:3 Topics: Animals; Atropine; Brain Damage, Chronic; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Guinea Pigs; Ketamine; Lethal Dose 50; Male; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Soman; Status Epilepticus; Stereoisomerism	2007
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats. Drug and chemical toxicology, 2007, Volume: 30, Issue:2 Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Structure-Activity Relationship	2007
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats. Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:5 Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Muscarinic Antagonists; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Soman	2007
Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology, 2009, Volume: 30, Issue:1 Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Cholinesterase Reactivators; Corpus Striatum; Doublecortin Protein; Hippocampus; Male; Maze Learning; Neurogenesis; Olanzapine; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Seizures; Soman	2009
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice. Toxicology mechanisms and methods, 2009, Volume: 19, Issue:9 Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Male; Mice; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Trimedoxime	2009
A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats. Toxicology mechanisms and methods, 2010, Volume: 20, Issue:8 Topics: Animals; Atropine; Behavior, Animal; Chemical Warfare Agents; Drug Therapy, Combination; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman	2010
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase. Chemical communications (Cambridge, England), 2011, May-14, Volume: 47, Issue:18 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Molecular Structure; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridines; Pyridinium Compounds; Soman	2011
Increasing oxime efficacy by blood-brain barrier modulation. Toxicology letters, 2011, Sep-25, Volume: 206, Issue:1 Topics: Animals; Antidotes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Electrophoresis, Capillary; Male; Microdialysis; Oximes; Pyridinium Compounds; Quinolines; Rats; Rats, Wistar; Seizures; Soman	2011
A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats. Drug and chemical toxicology, 2011, Volume: 34, Issue:3 Topics: Animals; Behavior, Animal; Drug Therapy, Combination; Male; Molecular Structure; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Trimedoxime	2011
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6. Toxicology letters, 2011, Sep-25, Volume: 206, Issue:1 Topics: Acetylcholinesterase; Aged; Chemical Warfare Agents; Cholinesterase Reactivators; Electric Stimulation; Humans; In Vitro Techniques; Intercostal Muscles; Muscle Strength; Neuromuscular Junction; Organophosphates; Oximes; Pyridinium Compounds; Sarin; Soman	2011
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model. Bratislavske lekarske listy, 2011, Volume: 112, Issue:10 Topics: Animals; Antidotes; Atropine; Biomarkers; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Trimedoxime	2011
Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication. Toxicology, 2011, Dec-18, Volume: 290, Issue:2-3 Topics: Acetylcholinesterase; Animals; Atropine; Cerebellum; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Drug Therapy, Combination; Gene Expression Regulation; Hippocampus; Olfactory Pathways; Oximes; Phosphorylation; Polymerase Chain Reaction; Pyridinium Compounds; Rats; Rats, Wistar; Soman	2011
A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice. Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:4 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Isoquinolines; Lethal Dose 50; Male; Mice; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Soman	2012
Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys. Environmental toxicology and pharmacology, 2012, Volume: 33, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Muscarinic Antagonists; Oximes; Physostigmine; Poisoning; Procyclidine; Pyridinium Compounds; Soman; Transdermal Patch	2012
[Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos]. Vojnosanitetski pregled, 2011, Volume: 68, Issue:12 Topics: Animals; Antidotes; Cholinesterase Reactivators; Dichlorvos; Drug Therapy, Combination; Male; Memantine; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman	2011
Correlation between butyrylcholinesterase variants and sensitivity to soman toxicity. Acta biochimica Polonica, 2012, Volume: 59, Issue:2 Topics: Adult; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Gene Frequency; Genetic Association Studies; Humans; In Vitro Techniques; Male; Middle Aged; Oximes; Polymorphism, Genetic; Pyridinium Compounds; Soman	2012
Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: Animals; Anticonvulsants; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Electroencephalography; Fluoresceins; Fluorescent Dyes; Injections, Intramuscular; Isoquinolines; Male; Muscarinic Antagonists; Nerve Degeneration; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Soman; Tetrazoles; Tissue Fixation	2013
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats. European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3 Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cyclopropanes; Drug Interactions; Glycine; Levetiracetam; Male; Oximes; Piracetam; Procyclidine; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Seizures; Soman	2013
Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes. BMC neuroscience, 2014, Apr-04, Volume: 15 Topics: Animals; Antidotes; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; GABA Modulators; Male; Midazolam; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Survival Rate; Treatment Outcome	2014
Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes. Chemical research in toxicology, 2015, May-18, Volume: 28, Issue:5 Topics: Acetylcholinesterase; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Mice; Models, Molecular; Oximes; Point Mutation; Pyridinium Compounds; Soman	2015
Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. Neuromolecular medicine, 2015, Volume: 17, Issue:3 Topics: alpha-Linolenic Acid; Animals; Antigens, Nuclear; Atropine Derivatives; Avoidance Learning; Brain Damage, Chronic; Brain-Derived Neurotrophic Factor; Diazepam; DNA Replication; Doublecortin Domain Proteins; Electroshock; Exploratory Behavior; Hippocampus; Male; Mechanistic Target of Rapamycin Complex 1; Microtubule-Associated Proteins; Multiprotein Complexes; Nerve Tissue Proteins; Neurogenesis; Neuropeptides; Neuroprotective Agents; Neurotoxins; Oximes; Proto-Oncogene Proteins c-akt; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; Sirolimus; Soman; Status Epilepticus; TOR Serine-Threonine Kinases	2015
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats. Neurotoxicology, 2015, Volume: 50 Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Levetiracetam; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Piracetam; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman	2015
Rapid-releasing of HI-6 via brain-targeted mesoporous silica nanoparticles for nerve agent detoxification. Nanoscale, 2016, May-05, Volume: 8, Issue:18 Topics: Animals; Brain; Drug Liberation; Mice; Nanoparticles; Nerve Agents; Oximes; Pyridinium Compounds; Rats; Silicon Dioxide; Soman; Zebrafish	2016
Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase. Toxicology letters, 2016, Mar-30, Volume: 246 Topics: Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Oximes; Pyridinium Compounds; Soman	2016
Increasing nerve agent treatment efficacy by P-glycoprotein inhibition. Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B Topics: Acetylcholinesterase; Animals; ATP Binding Cassette Transporter, Subfamily B; Atropine; Blood-Brain Barrier; Brain; Dogs; Madin Darby Canine Kidney Cells; Male; Nerve Agents; Oximes; Pyridinium Compounds; Quinolines; Rats; Rats, Wistar; Seizures; Soman; Substrate Specificity	2016
The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study. Toxicology letters, 2018, Sep-01, Volume: 293 Topics: Acetylcholinesterase; Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Erythrocytes; Guinea Pigs; Humans; Kinetics; Oximes; Pyridinium Compounds; Soman; Species Specificity	2018
Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point. Toxicology letters, 2018, Sep-01, Volume: 293 Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Endpoint Determination; Guinea Pigs; Injections, Intramuscular; Lethal Dose 50; Nicotinic Antagonists; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman; Survival Analysis	2018
Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. Neurotoxicology, 2018, Volume: 68 Topics: Animals; Anticonvulsants; Astrocytes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Male; Microglia; Neurons; Neuroprotective Agents; Oximes; Pyridinium Compounds; Quinolines; Rats, Wistar; Seizures; Soman	2018
Prophylactic potential of memantine against soman poisoning in rats. Toxicology, 2019, 03-15, Volume: 416 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; GPI-Linked Proteins; Male; Memantine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Soman; Synaptic Transmission	2019