Page last updated: 2024-09-04

sodium salicylate and ibuprofen

sodium salicylate has been researched along with ibuprofen in 24 studies

Compound Research Comparison

Studies
(sodium salicylate)
Trials
(sodium salicylate)
Recent Studies (post-2010)
(sodium salicylate)
Studies
(ibuprofen)
Trials
(ibuprofen)
Recent Studies (post-2010) (ibuprofen)
2,0315017110,2451,7814,267

Protein Interaction Comparison

ProteinTaxonomysodium salicylate (IC50)ibuprofen (IC50)
Prostaglandin G/H synthase 1 Bos taurus (cattle)2.9
Prostaglandin G/H synthase 2 Bos taurus (cattle)1.1
AlbuminBos taurus (cattle)3
Prostaglandin G/H synthase 1Ovis aries (sheep)4.0919
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.22
Prostaglandin G/H synthase 1Homo sapiens (human)1.6273
Caspase-1Homo sapiens (human)7.2667
Substance-P receptorCavia porcellus (domestic guinea pig)1.1
Prostaglandin G/H synthase 2Homo sapiens (human)3.0687
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)1.3
Aldo-keto reductase family 1 member C3Homo sapiens (human)10
Caspase-3Homo sapiens (human)7.2667
Caspase-4Homo sapiens (human)7.2667
4-aminobutyrate aminotransferase, mitochondrialRattus norvegicus (Norway rat)1.1
Caspase-5Homo sapiens (human)7.2667
Caspase-9Homo sapiens (human)7.2667
Prostaglandin G/H synthase 2Ovis aries (sheep)1.1375
Mu-type opioid receptorCavia porcellus (domestic guinea pig)2.9
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)5
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.54
Solute carrier family 22 member 6Homo sapiens (human)8
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)1.3

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199010 (41.67)18.7374
1990's10 (41.67)18.2507
2000's1 (4.17)29.6817
2010's3 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brown, KA; Collins, AJ1
Adkinson, NF; Kordansky, D; Norman, PS; Rosenthal, RR1
Chen, M; Robertson, RP1
Gieldanowski, J1
Ghosh, P; Horsburgh, BA; McKenzie, LS; Taylor, TK1
Deodger, ShD; Dik, VS; Grennan, DM; Li, P; Starrok, RD1
Drews, G; Garrino, MG; Henquin, JC1
Aou, S; Hori, T; Niijima, A; Oomura, Y1
Miyazaki, M; Toda, N; Yamamoto, M1
Fujimoto, W; Metz, S; Robertson, RP1
Kuna, ST; Levine, S1
Fujimoto, WY; Metz, SA; Robertson, RP1
Aeberhard, EE; Arabolos, NS; Barrett, CT; Castro, FE; Griscavage, JM; Henderson, SA; Ignarro, LJ1
Brandt, KD; Cole, CA; Hugenberg, ST1
Akarasereenont, P; Flower, RJ; Mitchell, JA; Thiemermann, C; Vane, JR1
McCrory, RM; Scott, EM; Tariq, VN1
Kolyada, AY; Madias, NE; Savikovsky, N1
Alpert, D; Schwenger, P; Skolnik, EY; Vilcek, J1
Ahmad, M; Li, WQ; Morin, I; Su, S; Zafarullah, M1
Callery, MP; McDade, TP; Perugini, RA; Vittimberga, FJ1
Brooks, G; Crabbe, MJ; Harper, JV; Shattock, MJ; Wang, Y; Yu, XM1
Gaissmaier, T; Hopf, C; Hüllen, V; Siebenhaar, M; Todorova, V1
Leão, RM; Zugaib, J1
Bhaskarla, C; Nandi, D; Sadhir, I; Sreedharan, S; Verma, T1

Trials

1 trial(s) available for sodium salicylate and ibuprofen

ArticleYear
Asthma improved by nonsteroidal anti-inflammatory drugs.
    Annals of internal medicine, 1978, Volume: 88, Issue:4

    Topics: Airway Resistance; Anti-Inflammatory Agents; Aspirin; Asthma; Clinical Trials as Topic; Female; Forced Expiratory Volume; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Middle Aged; Phenylbutazone; Placebos; Respiratory Function Tests; Sodium Salicylate; Spirometry; Tartrazine

1978

Other Studies

23 other study(ies) available for sodium salicylate and ibuprofen

ArticleYear
Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.
    Annals of the rheumatic diseases, 1977, Volume: 36, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Migration Inhibition; Cell Movement; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indomethacin; Leukocytes; Phenylbutazone; Rats; Sodium Salicylate

1977
Effects of prostaglandin synthesis inhibitors on human insulin secretion and carbohydrates tolerance.
    Prostaglandins, 1979, Volume: 18, Issue:4

    Topics: Adult; Aspirin; Blood Glucose; Dose-Response Relationship, Drug; Glucose Tolerance Test; Humans; Ibuprofen; Indomethacin; Insulin; Insulin Secretion; Male; Middle Aged; Prostaglandin Antagonists; Prostaglandins E; Secretory Rate; Sodium Salicylate

1979
Nonsteroid anti-inflammatory drugs in the treatment of immunologic iridocyclitis in the rabbit.
    Archivum immunologiae et therapiae experimentalis, 1977, Volume: 25, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Aqueous Humor; Female; Ibuprofen; Indomethacin; Male; Orosomucoid; Oxyphenbutazone; Proteins; Rabbits; Sialic Acids; Sodium Salicylate; Uveitis, Anterior

1977
Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage.
    Annals of the rheumatic diseases, 1976, Volume: 35, Issue:6

    Topics: Aged; Aging; Anti-Inflammatory Agents; Cartilage, Articular; Depression, Chemical; Flurbiprofen; Glycosaminoglycans; Humans; Hydrocortisone; Ibuprofen; In Vitro Techniques; Indomethacin; Middle Aged; Sodium Salicylate

1976
[Evaluation of the effectiveness of antirheumatic preparations].
    Terapevticheskii arkhiv, 1975, Volume: 47, Issue:11

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Evaluation; Female; Humans; Ibuprofen; Indomethacin; Joints; Male; Meprobamate; Methods; Middle Aged; Prednisolone; Sodium Salicylate

1975
Ionic, electrical, and secretory effects of inhibitors of arachidonic acid metabolism in mouse pancreatic beta-cells.
    Diabetes, 1992, Volume: 41, Issue:5

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Aspirin; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclooxygenase Inhibitors; Electric Conductivity; Female; Glucose; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Insulin; Islets of Langerhans; Lipoxygenase Inhibitors; Membrane Potentials; Mice; Microelectrodes; Potassium; Potassium Channels; Radioimmunoassay; Rubidium Radioisotopes; Sodium Salicylate

1992
The effects of interleukin-1 beta on the activity of adrenal, splenic and renal sympathetic nerves in the rat.
    Journal of the autonomic nervous system, 1991, Volume: 36, Issue:3

    Topics: Adrenal Glands; Anesthesia; Animals; Blood Pressure; Ibuprofen; Interleukin-1; Kidney; Male; Neurons; Neurons, Efferent; Rats; Rats, Inbred Strains; Recombinant Proteins; Sodium Salicylate; Spleen; Sympathetic Nervous System

1991
Interaction between non-steroidal antiinflammatory agents and sodium salicylate in the relaxant response of dog renal arteries to angiotensin II.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 274, Issue:2

    Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Dogs; Epoprostenol; Female; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Meclofenamic Acid; Muscle Relaxation; Muscle, Smooth, Vascular; Renal Artery; Sodium Salicylate

1985
Modulation of insulin secretion by cyclic AMP and prostaglandin E: the effects of theophylline, sodium salicylate and tolbutamide.
    Metabolism: clinical and experimental, 1982, Volume: 31, Issue:10

    Topics: Animals; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; Ibuprofen; Insulin; Insulin Secretion; Islets of Langerhans; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium Salicylate; Theophylline; Tolbutamide

1982
Relationship between cyclooxygenase activity (COA) inhibition and stimulation of ventilation by salicylate.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3

    Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Hydroxybenzoates; Ibuprofen; Indomethacin; Infusions, Intra-Arterial; Respiration; Salicylates; Sodium Chloride; Sodium Salicylate

1981
Inhibition of prostaglandin E synthesis augments glucose-induced insulin secretion is cultured pancreas.
    Diabetes, 1981, Volume: 30, Issue:7

    Topics: Animals; Cells, Cultured; Glucose; Ibuprofen; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Prostaglandins E; Rats; Sodium Salicylate

1981
Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene.
    Biochemical and biophysical research communications, 1995, Mar-28, Volume: 208, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression; Ibuprofen; Indomethacin; Isoenzymes; Kinetics; Macrophages, Alveolar; Nitric Oxide Synthase; Rats; Sodium Salicylate

1995
Effect of sodium salicylate, aspirin, and ibuprofen on enzymes required by the chondrocyte for synthesis of chondroitin sulfate.
    The Journal of rheumatology, 1993, Volume: 20, Issue:12

    Topics: Animals; Aspirin; Cartilage, Articular; Cattle; Chondroitin Sulfates; Dose-Response Relationship, Drug; Glucuronosyltransferase; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Ibuprofen; Sodium Salicylate; Uridine Diphosphate Glucose Dehydrogenase

1993
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Dec-15, Volume: 90, Issue:24

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blotting, Western; Cattle; Cell Line; Cell Survival; Cyclooxygenase Inhibitors; Eicosanoids; Endothelium, Vascular; Enzyme Induction; Ibuprofen; Indomethacin; Kinetics; Macrophages; Mice; Models, Biological; Prostaglandin-Endoperoxide Synthases; Sodium Salicylate

1993
Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:12

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis; Densitometry; Drug Synergism; Fluconazole; Humans; Ibuprofen; Microbial Sensitivity Tests; Parabens; Sodium Salicylate

1995
Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: evidence for tissue specificity.
    Biochemical and biophysical research communications, 1996, Mar-27, Volume: 220, Issue:3

    Topics: Animals; Aorta; Base Sequence; Cell Survival; Cells, Cultured; DNA Primers; Enhancer Elements, Genetic; Gene Expression; Gene Expression Regulation, Enzymologic; Humans; Ibuprofen; Isoenzymes; Lipopolysaccharides; Luciferases; Macrophages; Mice; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Specificity; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Restriction Mapping; Saphenous Vein; Sodium Salicylate; Transcription, Genetic; Transfection

1996
Cell-type-specific activation of c-Jun N-terminal kinase by salicylates.
    Journal of cellular physiology, 1999, Volume: 179, Issue:1

    Topics: Acetaminophen; Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; Colonic Neoplasms; COS Cells; Cyclooxygenase Inhibitors; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Hypertonic Solutions; Ibuprofen; Indomethacin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Organ Specificity; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Saline Solution, Hypertonic; Signal Transduction; Sodium Salicylate; Sorbitol; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1999
Induction of stromelysin gene expression by tumor necrosis factor alpha is inhibited by dexamethasone, salicylate, and N-acetylcysteine in synovial fibroblasts.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Cattle; Cells, Cultured; Dexamethasone; Fibroblasts; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Ibuprofen; Indomethacin; Matrix Metalloproteinase 3; Proline; Sodium Salicylate; Synovial Membrane; Thiocarbamates; Tissue Inhibitor of Metalloproteinase-3; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vitamin E

1999
Sodium salicylate inhibits macrophage TNF-alpha production and alters MAPK activation.
    The Journal of surgical research, 1999, Jun-15, Volume: 84, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Dinoprostone; Enzyme Activation; Ibuprofen; Lipopolysaccharides; Macrophages; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Sodium Salicylate; Tumor Necrosis Factor-alpha

1999
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle.
    The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Cell Division; Cell Line; Diclofenac; Dose-Response Relationship, Drug; Flow Cytometry; Ibuprofen; Indomethacin; Muscle, Smooth, Vascular; Rats; Sodium Salicylate; Sulindac

2003
Therapeutic drug monitoring in dried blood spots using liquid microjunction surface sampling and high resolution mass spectrometry.
    The Analyst, 2016, Feb-07, Volume: 141, Issue:3

    Topics: Acetaminophen; Chromatography, Liquid; Dried Blood Spot Testing; Drug Monitoring; Feasibility Studies; Humans; Ibuprofen; Point-of-Care Systems; Sodium Salicylate; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tolbutamide; Uric Acid

2016
Enhancement of Endocannabinoid-dependent Depolarization-induced Suppression of Excitation in Glycinergic Neurons by Prolonged Exposure to High Doses of Salicylate.
    Neuroscience, 2018, 04-15, Volume: 376

    Topics: Animals; Calcium; Cochlear Nucleus; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Glycine; Ibuprofen; Male; Neurons; Rats, Wistar; Receptor, Cannabinoid, CB1; Sodium Salicylate; Synapses; Tinnitus; Tissue Culture Techniques

2018
Non-steroidal anti-inflammatory drugs, acetaminophen and ibuprofen, induce phenotypic antibiotic resistance in Escherichia coli: roles of marA and acrB.
    FEMS microbiology letters, 2018, 11-01, Volume: 365, Issue:22

    Topics: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; DNA-Binding Proteins; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Ibuprofen; Microscopy, Atomic Force; Multidrug Resistance-Associated Proteins; Protease La; Sodium Salicylate; Transcription Factors

2018