sodium-pertechnetate-tc-99m and iotrolan

A rabbit model was used to assess the effects of intracarotid injections of ionic monomer (meglumine iothalamate), non-ionic monomer (iohexol, iopromide), and non-ionic dimer (iotrol) contrast materials on the blood-brain barrier. The degree of blood-brain barrier damage was assessed qualitatively using Evans' blue dye, and quantitatively by calculating the difference in pertechnetate uptake between injected and non-injected hemispheres. The results showed that the non-ionic dimer, iotrol, had the least effect on the blood-brain barrier, and that although iopromide and iohexol produced greater damage than iotrol, the ionic compound, meglumine iothalamate, caused the greatest disruption to the blood-brain barrier. The implications of these findings are discussed.

Topics: Animals; Blood-Brain Barrier; Carotid Arteries; Contrast Media; Evans Blue; Female; Injections, Intra-Arterial; Iohexol; Iothalamate Meglumine; Male; Rabbits; Sodium Pertechnetate Tc 99m; Triiodobenzoic Acids