sodium-pertechnetate-tc-99m and 1-2-distearoyllecithin

sodium-pertechnetate-tc-99m has been researched along with 1-2-distearoyllecithin* in 2 studies

Other Studies

2 other study(ies) available for sodium-pertechnetate-tc-99m and 1-2-distearoyllecithin

Article	Year
Use of liposomes as carriers for radiation synovectomy. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1988, Volume: 15, Issue:2 Using [99mTc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99mTc-containing liposomes into the knee joints of rabbits, retention of 99mTc in the knee was more than 200 times greater than following injection of nonencapsulated [99mTc]pertechnetate. The knee clearance biologic half time of 99mTc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111In(oxine), a knee clearance biologic half time of greater than 1200 h was observed. Topics: Animals; Indium Radioisotopes; Liposomes; Organometallic Compounds; Oxyquinoline; Permeability; Phosphatidylcholines; Rabbits; Sodium Pertechnetate Tc 99m; Sphingomyelins; Synovial Membrane; Tissue Distribution	1988
Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1986, Volume: 13, Issue:3 Multilamellar liposomes composed of eight different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) were prepared containing [99mTc]pertechnetate. The in vitro permeability of the liposome preparations in buffer and serum were measured by both dialysis and direct exposure. Liposomes composed of 25-33% SM were least permeable exhibiting leakage half-times of approximately 70 h in buffer and 52 h in serum. Pertechnetate-containing liposomes of three different lipid compositions were injected into mice and the biodistribution of 99mTc activity was determined. All preparations were taken up primarily by the lungs and liver. The half-time for clearance of 99mTc activity ranged from 24.8 to 30.6 h for the liver and 25.3 to 33.0 h for the lungs. Topics: Animals; Female; Liposomes; Mice; Mice, Inbred Strains; Phosphatidylcholines; Sodium Pertechnetate Tc 99m; Sphingomyelins; Structure-Activity Relationship; Tissue Distribution	1986

Article

Year

Use of liposomes as carriers for radiation synovectomy.

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1988, Volume: 15, Issue:2

Using [99mTc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99mTc-containing liposomes into the knee joints of rabbits, retention of 99mTc in the knee was more than 200 times greater than following injection of nonencapsulated [99mTc]pertechnetate. The knee clearance biologic half time of 99mTc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111In(oxine), a knee clearance biologic half time of greater than 1200 h was observed.

Topics: Animals; Indium Radioisotopes; Liposomes; Organometallic Compounds; Oxyquinoline; Permeability; Phosphatidylcholines; Rabbits; Sodium Pertechnetate Tc 99m; Sphingomyelins; Synovial Membrane; Tissue Distribution

1988

Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio.

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1986, Volume: 13, Issue:3

Multilamellar liposomes composed of eight different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) were prepared containing [99mTc]pertechnetate. The in vitro permeability of the liposome preparations in buffer and serum were measured by both dialysis and direct exposure. Liposomes composed of 25-33% SM were least permeable exhibiting leakage half-times of approximately 70 h in buffer and 52 h in serum. Pertechnetate-containing liposomes of three different lipid compositions were injected into mice and the biodistribution of 99mTc activity was determined. All preparations were taken up primarily by the lungs and liver. The half-time for clearance of 99mTc activity ranged from 24.8 to 30.6 h for the liver and 25.3 to 33.0 h for the lungs.

Topics: Animals; Female; Liposomes; Mice; Mice, Inbred Strains; Phosphatidylcholines; Sodium Pertechnetate Tc 99m; Sphingomyelins; Structure-Activity Relationship; Tissue Distribution

1986