sodium-oxybate and preproenkephalin

sodium-oxybate has been researched along with preproenkephalin* in 1 studies

Other Studies

1 other study(ies) available for sodium-oxybate and preproenkephalin

Article	Year
Prodynorphin and proenkephalin mRNAs are increased in rat brain after acute and chronic administration of gamma-hydroxybutyrate. Neuroscience letters, 1999, Feb-26, Volume: 262, Issue:1 The effects of gamma-hydroxybutyrate (GHB) on prodynorphin (PD) and proenkephalin (PE) mRNA expression were examined using in situ hybridization histochemistry in discrete rat brain structures rich in GHB receptors. A single dose of GHB (500 mg/kg i.p.) increased striatal PE mRNA levels (+60%) between 15 and 90 min after injection. An increase in PD mRNA expression was observed in the frontal cortex (+90%) 6 h after GHB administration. Chronic exposure to GHB (500 mg/kg i.p. twice a day) for 10 days induced significant increases in both PE and PD mRNA levels in different brain regions examined, suggesting that PD and PE mRNA expressions are modulated by the endogenous GHBergic system. Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Brain; Dose-Response Relationship, Drug; Enkephalins; Injections, Intraperitoneal; Male; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sodium Oxybate	1999

Article

Year

Prodynorphin and proenkephalin mRNAs are increased in rat brain after acute and chronic administration of gamma-hydroxybutyrate.

Neuroscience letters, 1999, Feb-26, Volume: 262, Issue:1

The effects of gamma-hydroxybutyrate (GHB) on prodynorphin (PD) and proenkephalin (PE) mRNA expression were examined using in situ hybridization histochemistry in discrete rat brain structures rich in GHB receptors. A single dose of GHB (500 mg/kg i.p.) increased striatal PE mRNA levels (+60%) between 15 and 90 min after injection. An increase in PD mRNA expression was observed in the frontal cortex (+90%) 6 h after GHB administration. Chronic exposure to GHB (500 mg/kg i.p. twice a day) for 10 days induced significant increases in both PE and PD mRNA levels in different brain regions examined, suggesting that PD and PE mRNA expressions are modulated by the endogenous GHBergic system.

Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Brain; Dose-Response Relationship, Drug; Enkephalins; Injections, Intraperitoneal; Male; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sodium Oxybate

1999