sodium-nitrite and ferulic-acid

sodium-nitrite has been researched along with ferulic-acid* in 2 studies

Other Studies

2 other study(ies) available for sodium-nitrite and ferulic-acid

Article	Year
[The action of inhibitors of the amine nitrosation reaction in human gastric juice and in the body of animals]. Voprosy onkologii, 1989, Volume: 35, Issue:1 The effect of ascorbic, ferulic and caffeic acids on dimethylamine and amidopyrine nitrosation in a medium containing 3 samples of total gastric juice taken from 10 humans (pH = 6.1; 3.2 and 1.7) was studied versus the amount of inhibitor added to the medium. The resultant relationship proved bizarre, the inhibitor at low concentrations stimulating nitrosation in some situations. When gastric juice concentration in the medium was further lowered by dilution with a buffer at relevant value of pH, the paradoxical effect of inhibition gradually disappeared. Topics: Aminopyrine; Animals; Ascorbic Acid; Caffeic Acids; Chromatography, Gas; Coumaric Acids; Dimethylamines; Gastric Juice; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Mice, Inbred Strains; Nitrosamines; Sodium Nitrite	1989
Caffeic and ferulic acid as blockers of nitrosamine formation. Carcinogenesis, 1984, Volume: 5, Issue:3 Caffeic acid and ferulic acid, which are naturally occurring phenols present in a wide variety of plants, were examined for their ability to react with nitrite in vitro and to inhibit nitrosamine formation in vivo. Their activities were compared with other phenols (butylated hydroxyanisole and Trolox) and with a non-phenolic polyhydroxylated compound, glycerol guaiacolate. In simulated gastric fluid, caffeic acid and ferulic acid reacted rapidly and completely with an equimolar quantity of sodium nitrite. In rats receiving aminopyrine and nitrite, caffeic acid and ferulic acid blocked the elevation of serum N-nitrosodimethylamine (NDMA) levels and the serum glutamic pyruvic transaminase levels associated with hepatotoxicity. Neither phenol had any effect on serum levels of NDMA in rats treated with NDMA. In both the in vitro (reaction with nitrite) and in vivo (inhibition of hepatotoxicity) systems, caffeic acid was more effective than ferulic acid. Butylated hydroxyanisole and Trolox were partially effective, and glycerol guaiacolate was inactive. The results of this study suggest that dietary caffeic acid and ferulic acid may play a role in the body's defense against carcinogenesis by inhibiting the formation of N-nitroso compounds. Topics: Alanine Transaminase; Aminopyrine; Animals; Caffeic Acids; Cholagogues and Choleretics; Cinnamates; Coumaric Acids; Gastric Juice; Kinetics; Male; Mutagenicity Tests; Mutation; Nitrites; Nitrosamines; Phenols; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium Nitrite	1984

Article

Year

[The action of inhibitors of the amine nitrosation reaction in human gastric juice and in the body of animals].

Voprosy onkologii, 1989, Volume: 35, Issue:1

The effect of ascorbic, ferulic and caffeic acids on dimethylamine and amidopyrine nitrosation in a medium containing 3 samples of total gastric juice taken from 10 humans (pH = 6.1; 3.2 and 1.7) was studied versus the amount of inhibitor added to the medium. The resultant relationship proved bizarre, the inhibitor at low concentrations stimulating nitrosation in some situations. When gastric juice concentration in the medium was further lowered by dilution with a buffer at relevant value of pH, the paradoxical effect of inhibition gradually disappeared.

Topics: Aminopyrine; Animals; Ascorbic Acid; Caffeic Acids; Chromatography, Gas; Coumaric Acids; Dimethylamines; Gastric Juice; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Mice, Inbred Strains; Nitrosamines; Sodium Nitrite

1989

Caffeic and ferulic acid as blockers of nitrosamine formation.

Carcinogenesis, 1984, Volume: 5, Issue:3

Caffeic acid and ferulic acid, which are naturally occurring phenols present in a wide variety of plants, were examined for their ability to react with nitrite in vitro and to inhibit nitrosamine formation in vivo. Their activities were compared with other phenols (butylated hydroxyanisole and Trolox) and with a non-phenolic polyhydroxylated compound, glycerol guaiacolate. In simulated gastric fluid, caffeic acid and ferulic acid reacted rapidly and completely with an equimolar quantity of sodium nitrite. In rats receiving aminopyrine and nitrite, caffeic acid and ferulic acid blocked the elevation of serum N-nitrosodimethylamine (NDMA) levels and the serum glutamic pyruvic transaminase levels associated with hepatotoxicity. Neither phenol had any effect on serum levels of NDMA in rats treated with NDMA. In both the in vitro (reaction with nitrite) and in vivo (inhibition of hepatotoxicity) systems, caffeic acid was more effective than ferulic acid. Butylated hydroxyanisole and Trolox were partially effective, and glycerol guaiacolate was inactive. The results of this study suggest that dietary caffeic acid and ferulic acid may play a role in the body's defense against carcinogenesis by inhibiting the formation of N-nitroso compounds.

Topics: Alanine Transaminase; Aminopyrine; Animals; Caffeic Acids; Cholagogues and Choleretics; Cinnamates; Coumaric Acids; Gastric Juice; Kinetics; Male; Mutagenicity Tests; Mutation; Nitrites; Nitrosamines; Phenols; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium Nitrite

1984