sodium-nitrite and 1-nitrosopiperazine

sodium-nitrite has been researched along with 1-nitrosopiperazine* in 1 studies

Other Studies

1 other study(ies) available for sodium-nitrite and 1-nitrosopiperazine

Article	Year
Excretion of N-mononitrosopiperazine in urine in workers manufacturing piperazine. International archives of occupational and environmental health, 1988, Volume: 60, Issue:1 Piperazine has been shown to nitrosate in vivo to N-mononitrosopiperazine (MNPZ) by oral intake. Urine from workers exposed to piperazine in a chemical plant was analysed for nitrosamines by gas chromatography-thermal energy analysis. In five out of 11 exposed cases, MNPZ excretion in urine was 0.3 to 4.7 micrograms/24 h (during and after a work shift). In four cases, MNPZ was detected in some urine samples, and in two cases MNPZ was not detected (less than 0.1 ng/ml). The individual excretion was strongly dependent on piperazine exposure, which ranged from 0.06 to 1.7 mg/m3 (time-weighted average; Spearman's rank correlation 0.78, P = 0.01). The MNPZ excretion showed no significant correlation with nitrite or nitrate in saliva (both: r = 0.50, P = 0.10). Topics: Adult; Air Pollutants, Occupational; Chemical Industry; Humans; Male; Middle Aged; Nitrates; Nitrosamines; Piperazine; Piperazines; Saliva; Sodium Nitrite	1988

Article

Year

Excretion of N-mononitrosopiperazine in urine in workers manufacturing piperazine.

International archives of occupational and environmental health, 1988, Volume: 60, Issue:1

Piperazine has been shown to nitrosate in vivo to N-mononitrosopiperazine (MNPZ) by oral intake. Urine from workers exposed to piperazine in a chemical plant was analysed for nitrosamines by gas chromatography-thermal energy analysis. In five out of 11 exposed cases, MNPZ excretion in urine was 0.3 to 4.7 micrograms/24 h (during and after a work shift). In four cases, MNPZ was detected in some urine samples, and in two cases MNPZ was not detected (less than 0.1 ng/ml). The individual excretion was strongly dependent on piperazine exposure, which ranged from 0.06 to 1.7 mg/m3 (time-weighted average; Spearman's rank correlation 0.78, P = 0.01). The MNPZ excretion showed no significant correlation with nitrite or nitrate in saliva (both: r = 0.50, P = 0.10).

Topics: Adult; Air Pollutants, Occupational; Chemical Industry; Humans; Male; Middle Aged; Nitrates; Nitrosamines; Piperazine; Piperazines; Saliva; Sodium Nitrite

1988