sodium-lactate and aluminum-lactate

Monoamine oxidase type B (MAO-B) activity is elevated in certain neurological diseases such as Alzheimer's and Parkinson's disease with respect to age-matched controls; the cause of this elevation is unknown. The documented accumulation of aluminum in certain neurodegenerative diseases prompted us to test the effect of Al3+ on the activity of MAO-B in rat brain homogenate. Results showed that the metal ion significantly increased MAO-B enzymatic activity in a dose-dependent manner, yielding a K(M) of 5.69 microM compared with 34.45 microM in the absence of the metal ion. The Vmax of 45.34 micromol/min was unchanged in the presence of the metal ion.

Topics: Aluminum; Aluminum Compounds; Alzheimer Disease; Animals; Brain; Cell Extracts; Deamination; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Lactates; Male; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Rats; Rats, Wistar; Sodium Lactate; Thermodynamics

Topics: Alum Compounds; Aluminum; Aluminum Compounds; Humans; Lactates; Skin; Sodium; Sodium Lactate; Zirconium