sodium-hypochlorite has been researched along with mestanolone* in 1 studies
1 other study(ies) available for sodium-hypochlorite and mestanolone
| Article | Year |
|---|---|
Efficient oxidizing methods for the synthesis of oxandrolone intermediates.
Mild, efficient and eco-friendly oxidation of 17alpha-methylandrostan-3beta-17beta-diol (1) has been studied with three different reagents viz. pentavalent iodine reagent 2-iodoxy benzoic acid (IBX) in DMSO at 65 degrees C, sodium hypochlorite and H2O2/Na2WO4 under phase transfer conditions to give 17beta-hydroxy-17alpha-methylandrostan-3-one (mestanolone 2), a drug intermediate as oxidized product. The H2O2/Na2WO4/PTC gave mestanolone in high yield and purity whereas sodium hypochlorite/PTC system yielded some chlorinated material along with the mestanolone. However, 1 with 2.5 equivalent of IBX gave 17beta-hydroxy-17alpha-methyl-Delta1-androsten-3-one (3) under the similar reaction conditions in good yield and single step reaction. Topics: Androstane-3,17-diol; Benzoic Acid; Chlorine; Dihydrotestosterone; Iodine; Models, Chemical; Oxandrolone; Oxidation-Reduction; Sodium Hypochlorite | 2004 |