sodium-hypochlorite and glycine-chloramine

Chemomechanical caries removal is an excellent method for minimally invasive caries excavation, and the removal agents are either sodium hypochlorite (NaOCl)- or enzyme-based. The NaOCl-based agents include GK-101, GK-101E (Caridex) and Carisolv, and the enzyme-based agents include Papacarie and the experimental material, Biosolv. This review outlines the changes in chemomechanical caries removal methods and focuses on recently published laboratory and clinical studies. The historical development, mechanism of action, excavation time and biological effects on pulp and dental hard tissues are described. Based on existing evidence, the currently available chemomechanical caries removal methods are viable alternatives to conventional rotary instrument methods. Chemomechanical methods could be extremely useful in very anxious, disabled and paediatric patients. It does seem some of these agents would still benefit from quicker excavation times in order to achieve more universal acceptance. However, as a means of conserving the caries-affected dentine, chemomechanical caries removal is possibly much more successful than conventional rotary instrumentation.

Topics: Aminobutyrates; Chloramines; Dental Caries; Dental Cavity Preparation; Disinfectants; Equipment Design; Glutamic Acid; Glycine; Hardness; Humans; Leucine; Lysine; Papain; Sodium Hypochlorite

A study was designed to assess the effects of the sodium salt of N-monochloroglycine (NMG) and sodium hypochlorite on the activity of salivary amylase. Concentrations of each agent were varied to determine the concentration at which the threshold and total inhibition of enzyme would be obtained. The data indicated that NMG at concentrations of 0.10% (w/v) does not affect amylase activity, whereas sodium hypochlorite at concentrations of 0.05% (w/v) totally inhibits salivary amylase activity.

Topics: Amylases; Chloramines; Chlorine; Glycine; Humans; Saliva; Sodium Hypochlorite