sodium-dodecyl-sulfate and celastrol

Two polymorphs of celastrol were discovered and fully characterized by X-ray powder diffraction, thermogravimetry analysis, and differential scanning calorimetry. The single-crystal structures of form I and the isostructural solvate of form II were disclosed by single-crystal X-ray diffraction. The apparent solubility and wettability of both the crystalline forms were determined. It was found that surfactant can significantly improve the solubility of celastrol up to more than 10

Topics: Crystallization; Crystallography, X-Ray; Models, Molecular; Pentacyclic Triterpenes; Polysorbates; Powder Diffraction; Sodium Dodecyl Sulfate; Solubility; Surface-Active Agents; Tripterygium; Triterpenes; Wettability; X-Ray Diffraction