sodium-butyrate and entinostat

sodium-butyrate has been researched along with entinostat* in 1 studies

Other Studies

1 other study(ies) available for sodium-butyrate and entinostat

ArticleYear
Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives.
    Journal of medicinal chemistry, 1999, Jul-29, Volume: 42, Issue:15

    Newly synthesized benzamide derivatives were evaluated for their inhibitory activity against histone deacetylase. The structure of these derivatives was unrelated to the known inhibitors, and IC(50) values of the active compounds were in the range of 2-50 microM. Structure-activity relationship on the benzanilide moiety showed that the 2'-substituent, an amino or hydroxy group, was indispensable for inhibitory activity. Although the electronic influence of the substituent in the anilide moiety showed only a small effect on inhibitory activity, the steric factor in the anilide moiety, especially at positions 3'and 4', played an important role in interaction with the enzyme. Among these benzamide derivatives, MS-275 (1), which showed significant antitumor activity in vivo, has been selected for further investigation.

    Topics: Antineoplastic Agents; Benzamides; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Pyridines; Structure-Activity Relationship

1999