sodium-bromide and dicyanmethane

Electrochemically induced catalytic multicomponent transformation of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized pyrano[2,3-c]pyrazole system in 78-99} yields. The developed efficient electrocatalytic approach to medicinally relevant spirocyclic [indole-3,4'-pyrano[2,3-c]pyrazoles] is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a novel example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reaction strategy.

Topics: Bromides; Catalysis; Cyclization; Electrochemistry; Ethanol; Isatin; Models, Chemical; Molecular Structure; Nitriles; Pyrazolones; Sodium Compounds; Spiro Compounds