sodium-borohydride has been researched along with phenanthroindolizidine* in 1 studies
1 other study(ies) available for sodium-borohydride and phenanthroindolizidine
| Article | Year |
|---|---|
Cyano Group Removal from Cyano-Promoted Aza-Diels-Alder Adducts: Synthesis and Structure-Activity Relationship of Phenanthroindolizidines and Phenanthroquinolizidines.
Phenanthroindolizidines and phenanthroquinolizidines were concisely synthesized by the reductive decyanization of cyano-promoted intramolecular aza-Diels-Alder cycloadducts followed by aryl-aryl coupling. Cyano groups were removed from α-aminoacrylonitriles via treatment with sodium borohydride in 2-propanol in almost quantitative yields; a possible mechanism was proposed and examined using D-labeling experiments. A systematic study of the effects of the phenanthrene substitution pattern on the anticancer activity against three human cancer cell lines was discussed. Topics: 2-Propanol; Antineoplastic Agents; Borohydrides; Catalysis; Drug Screening Assays, Antitumor; Humans; Indolizines; Molecular Structure; Phenanthrolines; Quinolizines; Structure-Activity Relationship | 2016 |