snx-7081 has been researched along with tanespimycin* in 1 studies
1 other study(ies) available for snx-7081 and tanespimycin
| Article | Year |
|---|---|
The novel Hsp-90 inhibitor SNX7081 is significantly more potent than 17-AAG against primary CLL cells and a range of haematological cell lines, irrespective of lesions in the TP53 pathway.
Inhibitors of heat-shockprotein 90 (Hsp90) have been proposed as a novel therapeutic option for Chronic Lymphocytic Leukaemia (CLL), particularly as their mechanism of action appears independent of mutations of ATM or TP53. We investigated the activity of a novel Hsp90 inhibitor, SNX7081, against a panel of eight haematological cell lines and 23 CLL patient samples. SNX7081 displayed significant effects on cell cycle distribution, apoptotic rate and levels of ZAP-70 in the cell lines and in the patient samples, irrespective of TP53 status. Our findings suggest SNX7081 may represent a promising therapeutic option for aggressive CLL. Topics: Antineoplastic Agents; Apoptosis; Benzamides; Benzoquinones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Genes, p53; Hematologic Neoplasms; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Leukemia, Lymphocytic, Chronic, B-Cell; Mutation; Neoplasm Proteins; Tumor Cells, Cultured; ZAP-70 Protein-Tyrosine Kinase | 2010 |