Page last updated: 2024-08-26

sn 38 and camptothecin

sn 38 has been researched along with camptothecin in 22 studies

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (27.27)	18.2507
2000's	8 (36.36)	29.6817
2010's	6 (27.27)	24.3611
2020's	2 (9.09)	2.80

Authors

Authors	Studies
Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL	1
Ejima, A; Kawato, Y; Matsumoto, K; Mitsui, I; Ohsuki, S; Sato, K; Sugimori, M; Tagawa, H; Uoto, K; Yasuoka, M	1
Burke, TG; Mi, Z	2
Fan, Y; Kohn, KW; Pommier, Y; Shi, LM; Weinstein, JN	1
Ejima, A; Hirota, Y; Kawato, Y; Mitsui, I; Ohsuki, S; Sato, K; Sugimori, M; Terasawa, H; Uoto, K	1
Bingcang, AL; Bom, D; Burke, TG; Chavan, AJ; Curran, DP; Du, W; Fraley, KA; Kohlhagen, G; Kruszewski, S; Latus, LJ; Pommier, Y; Thompson Strode, J; Zimmer, SG	1
Chang, K; Choi, WS; Im, GJ; Kim, DK; Kim, JS; Kim, TK; Kim, YW; Lee, JY; Lee, N; Ryu, DH	1
Beretta, G; Biasotti, B; Carenini, N; Carminati, P; Dallavalle, S; De Cesare, M; Ferrari, A; Gallo, G; Martinelli, R; Marzi, M; Merlini, L; Penco, S; Perego, P; Pisano, C; Pratesi, G; Tinti, MO; Zunino, F	1
Bearss, D; Manikumar, G; Von Hoff, DD; Wadkins, RM; Wall, ME; Wani, MC	1
Battistuzzi, G; Beretta, GL; Cabri, W; De Cesare, M; Giannini, G; Marastoni, E; Marzi, M; Pisano, C; Vesci, L; Zunino, F	1
Feng, W; LaVoie, EJ; Liu, AA; Liu, LF; Satyanarayana, M; Tsai, YC	1
Basili, S; Battaglia, A; Beretta, GL; Bombardelli, E; Fontana, G; Guerrini, A; Moro, S; Samorì, C; Tinelli, S; Varchi, G; Zunino, F	1
Jiang, C; Jin, W; Li, M; Lou, L; Tang, W; You, T; Zheng, C	1
Chen, Y; Huang, Q; Lu, W; Luo, Y; Tong, L; Yu, S	1
Huang, Q; Lu, W; Wang, L	1
Chen, Y; Huang, Q; Huang, Y; Lu, W; Tong, L; Wang, L; Zhang, J	1
Chang, LC; Goto, M; Hung, HY; Kuo, DH; Kuo, SC; Lee, KH; Liu, YQ; Morris-Natschke, SL; Nan, X; Pan, SL; Qian, K; Teng, CM; Wang, CY; Wang, MJ; Wu, TS; Wu, YC; Yang, JS; Yang, L; Yang, XM; Zhao, XB; Zhao, YL	1
Fujimoto, M; Fukuda, T; Ishibashi, F; Iwao, M; Nanjo, Y; Natsui, Y; Okazaki, F; To, H; Yoshida, K	1
Deng, T; Jiang, ZX; Mao, X; Xiao, Y; Yang, Z; Zheng, X	1
Benedetti, P; Bizzarri, BM; Botta, L; Cesarini, S; Cirigliano, A; Filippi, S; Fiorucci, D; Negri, R; Paiardini, A; Rinaldi, T; Saladino, R; Zippilli, C	1
Chan, YW; Chang, CL; Chang, LH; Chao, YT; Chen, SF; Chen, YC; Chen, YF; Chou, SY; Chuang, SH; Gao, YS; Hsu, PC; Hsueh, WY; Huang, GR; Huang, HY; Huang, JJ; Huang, MS; Huang, PH; Huang, SY; Huang, YC; Jian, BH; Kao, YF; Lai, CH; Lee, YE; Lin, HS; Lin, JC; Lin, SF; Lin, YH; Liu, HH; Lo, TH; Lu, YY; Teng, LW; Wang, SY; Wei, WY; Yang, SC; Yuan, TT	1

Reviews

1 review(s) available for sn 38 and camptothecin

Article	Year
Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European journal of medicinal chemistry, 2013, Volume: 63 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors	2013

Other Studies

21 other study(ies) available for sn 38 and camptothecin

Article	Year
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous	1991
Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues. Journal of medicinal chemistry, 1994, Sep-16, Volume: 37, Issue:19 Topics: Animals; Antineoplastic Agents; Camptothecin; Drug Screening Assays, Antitumor; Leukemia P388; Mice; Neoplasms, Experimental; Polycyclic Compounds; Structure-Activity Relationship; Tumor Cells, Cultured	1994
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1 Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Half-Life; Irinotecan; Kinetics; Lactones; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Topotecan	1994
Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin. Journal of medicinal chemistry, 1993, Aug-20, Volume: 36, Issue:17 Topics: Antineoplastic Agents, Phytogenic; Binding Sites; Camptothecin; Half-Life; Humans; Irinotecan; Lactones; Serum Albumin; Structure-Activity Relationship	1993
Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13 Topics: Amino Acid Substitution; Antineoplastic Agents; Binding Sites; Camptothecin; DNA; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Enzyme Inhibitors; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Conformation; Mutation; Protein Conformation; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Topoisomerase I Inhibitors	1998
Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13 Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Irinotecan; Leukemia P388; Mice; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1998
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity. Journal of medicinal chemistry, 2000, Oct-19, Volume: 43, Issue:21 Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; Drug Screening Assays, Antitumor; Drug Stability; Electrophoresis, Agar Gel; Humans; Hydrolysis; Kinetics; Mice; Mice, Nude; Organosilicon Compounds; Spectrometry, Fluorescence; Structure-Activity Relationship; Tumor Cells, Cultured	2000
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues. Journal of medicinal chemistry, 2001, May-10, Volume: 44, Issue:10 Topics: Animals; Antineoplastic Agents; Camptothecin; Cholinesterase Inhibitors; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Structure-Activity Relationship; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity. Journal of medicinal chemistry, 2001, Sep-27, Volume: 44, Issue:20 Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Imines; Immunoblotting; Inhibitory Concentration 50; Mice; Mice, Nude; Quantitative Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction. Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Ketones; Structure-Activity Relationship; Topoisomerase I Inhibitors	2004
E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation. Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2008
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Bioorganic & medicinal chemistry, 2009, Apr-01, Volume: 17, Issue:7 Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type I; Humans; Phenanthridines; Topoisomerase I Inhibitors	2009
Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins. Journal of medicinal chemistry, 2009, Feb-26, Volume: 52, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; Computer Simulation; Models, Molecular; Protein Binding; Quantitative Structure-Activity Relationship; Stereoisomerism; Thermodynamics	2009
7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hydrolysis; Inhibitory Concentration 50; Irinotecan; Models, Chemical; Rhodamines; Structure-Activity Relationship; Topotecan	2009
Synthesis and biological evaluation of new homocamptothecin analogs. European journal of medicinal chemistry, 2012, Volume: 54 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA Topoisomerases, Type I; Drug Stability; Humans; Structure-Activity Relationship; Topoisomerase I Inhibitors	2012
Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs. Bioorganic & medicinal chemistry letters, 2014, Mar-15, Volume: 24, Issue:6 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; DNA Topoisomerases, Type I; HCT116 Cells; HT29 Cells; Humans; Microwaves; Topoisomerase I Inhibitors	2014
Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents. Journal of medicinal chemistry, 2014, Jul-24, Volume: 57, Issue:14 Topics: Amidines; Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; HCT116 Cells; Humans; KB Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Conformation; Neoplasms, Experimental; Structure-Activity Relationship; Sulfonamides; Topoisomerase I Inhibitors	2014
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold. Bioorganic & medicinal chemistry, 2019, 01-15, Volume: 27, Issue:2 Topics: Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Coumarins; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Male; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Topoisomerase I Inhibitors	2019
Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs. Bioorganic & medicinal chemistry letters, 2019, 02-15, Volume: 29, Issue:4 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Liberation; Ethylene Glycols; Humans; Irinotecan; Prodrugs	2019
Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1. ACS medicinal chemistry letters, 2020, May-14, Volume: 11, Issue:5 Topics:	2020
Copper(I)-Catalyzed Nitrile-Addition/ Journal of medicinal chemistry, 2021, 02-11, Volume: 64, Issue:3 Topics: Animals; Antineoplastic Agents; Catalysis; Copper; DNA Topoisomerases, Type I; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Male; Mice; Mice, Nude; Models, Molecular; Molecular Docking Simulation; Nitriles; Quinolones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays	2021