Page last updated: 2024-09-03

sn 23862 and tretazicar

sn 23862 has been researched along with tretazicar in 15 studies

Compound Research Comparison

Studies
(sn 23862)
Trials
(sn 23862)
Recent Studies (post-2010)
(sn 23862)
Studies
(tretazicar)
Trials
(tretazicar)
Recent Studies (post-2010) (tretazicar)
2004205642

Protein Interaction Comparison

ProteinTaxonomysn 23862 (IC50)tretazicar (IC50)
Nitroreductase AEscherichia coli O157:H70.89

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (26.67)18.2507
2000's7 (46.67)29.6817
2010's3 (20.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Cliffe, S; Denny, WA; Palmer, BD; Wilson, WR1
Atwell, GJ; Denny, WA; Palmer, BD; Schultz, D; Wilson, WR; Xu, XZ1
Denny, WA; Friedlos, F; Palmer, BD; Springer, CJ1
Neidle, S; Parkinson, GN; Skelly, JV1
Atwell, GJ; Denny, WA; Hogg, A; Patterson, AV; Pruijn, FB; Pullen, SM; Wilson, WR; Yang, S1
Çelik, A; Yetiş, G1
Ay, M; Çelik, A; Gülhan, ÜG; Güngör, T; Hacıoğlu, N; Köçkar, F; Önder, FC; Tok, TT; Tokay, E2
Anlezark, GM; Denny, WA; Friedlos, F; Knox, RJ; Melton, RG; Palmer, BD; Sherwood, RF; Williams, A; Wilson, WR1
Kestell, P; Palmer, BD; Pruijn, FB; Siim, BG; Wilson, WR1
Denny, WA; Helsby, NA; Hicks, KO; Hogg, A; Pullen, SM; Wilson, WR1
Denny, WA; Helsby, NA; Palmer, BD; Pruijn, FB; Wheeler, SJ; Wilson, WR; Yang, S1
Denny, WA; Johansson, E; Neidle, S; Parkinson, GN1
Ferry, DM; Helsby, NA; Patterson, AV; Pullen, SM; Wilson, WR1
Ay, M; Celik, A; Gungor, T; Kockar, F; Onder, FC; Tok, TT; Tokay, E; Yetis, G1

Other Studies

15 other study(ies) available for sn 23862 and tretazicar

ArticleYear
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
    Journal of medicinal chemistry, 1992, Aug-21, Volume: 35, Issue:17

    Topics: Aniline Compounds; Aniline Mustard; Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; CHO Cells; Cricetinae; Humans; Molecular Structure; Mustard Compounds; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxygen; Rats; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured; Water

1992
Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Journal of medicinal chemistry, 1994, Jul-08, Volume: 37, Issue:14

    Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Hypoxia; CHO Cells; Cricetinae; NAD(P)H Dehydrogenase (Quinone); Rats; Structure-Activity Relationship

1994
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.
    Journal of medicinal chemistry, 1997, Apr-11, Volume: 40, Issue:8

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Enzyme Activation; Escherichia coli; Genetic Engineering; Mechlorethamine; Nitroreductases; Prodrugs

1997
Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.
    Journal of medicinal chemistry, 2000, Oct-05, Volume: 43, Issue:20

    Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Molecular Sequence Data; Nitroreductases; Prodrugs; Protein Structure, Tertiary

2000
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
    Journal of medicinal chemistry, 2007, Mar-22, Volume: 50, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Bystander Effect; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Escherichia coli Proteins; Female; Genetic Therapy; Humans; Least-Squares Analysis; Male; Mice; Mice, Nude; Multivariate Analysis; Nitrogen Mustard Compounds; Nitroreductases; Prodrugs; Quantitative Structure-Activity Relationship; Transplantation, Heterologous

2007
An unusually cold active nitroreductase for prodrug activations.
    Bioorganic & medicinal chemistry, 2012, Jun-01, Volume: 20, Issue:11

    Topics: Aniline Mustard; Aziridines; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Escherichia coli; Flavin Mononucleotide; Hydrogen-Ion Concentration; Mass Spectrometry; Nitrofurazone; Nitroreductases; Phylogeny; Prodrugs; Recombinant Proteins; Staphylococcus saprophyticus; Temperature

2012
PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells.
    European journal of medicinal chemistry, 2019, Jun-01, Volume: 171

    Topics: Amides; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Molecular Dynamics Simulation; Molecular Structure; Nitroreductases; PC-3 Cells; Prodrugs; Structure-Activity Relationship

2019
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.
    European journal of medicinal chemistry, 2020, Feb-01, Volume: 187

    Topics: Aniline Compounds; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Genetic Therapy; Humans; Male; Models, Molecular; Molecular Structure; Nitroreductases; Prodrugs; Prostatic Neoplasms; Structure-Activity Relationship

2020
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.
    Biochemical pharmacology, 1995, Aug-25, Volume: 50, Issue:5

    Topics: Aniline Mustard; Animals; Antineoplastic Agents; Aziridines; Biotransformation; Cell Line; Cricetinae; Escherichia coli; Kinetics; Nitroreductases; Oxidation-Reduction; Prodrugs; Substrate Specificity

1995
Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:5

    Topics: Aniline Mustard; Animals; Antineoplastic Agents; Aziridines; Biotransformation; Chromatography, High Pressure Liquid; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Prodrugs

2000
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.
    Cancer research, 2002, Mar-01, Volume: 62, Issue:5

    Topics: Aniline Mustard; Animals; Aziridines; Bystander Effect; Cell Culture Techniques; Cricetinae; Genetic Therapy; Humans; Neoplasms; Nitroreductases; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
    Chemical research in toxicology, 2003, Volume: 16, Issue:4

    Topics: Aniline Mustard; Animals; Antineoplastic Agents, Alkylating; Aziridines; Chromatography, High Pressure Liquid; Cricetinae; Electrochemistry; Hydrolysis; Kinetics; Mass Spectrometry; Nitroreductases; Prodrugs; Time Factors; Tumor Cells, Cultured

2003
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
    Journal of medicinal chemistry, 2003, Sep-11, Volume: 46, Issue:19

    Topics: Aniline Mustard; Aziridines; Benzamides; Binding Sites; Crystallography, X-Ray; Dicumarol; Drug Design; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavin Mononucleotide; Models, Molecular; Nitroreductases; Oxidation-Reduction; Prodrugs; Protein Binding

2003
2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.
    British journal of cancer, 2004, Mar-08, Volume: 90, Issue:5

    Topics: Aniline Mustard; Antineoplastic Agents; Aziridines; Bystander Effect; Chromatography, High Pressure Liquid; Escherichia coli; Genetic Therapy; Genetic Vectors; Humans; Mass Spectrometry; Neoplasms; Nitroreductases; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured

2004
Prodrugs for Nitroreductase Based Cancer Therapy- 1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2018, Volume: 14, Issue:5

    Topics: Aniline Mustard; Antineoplastic Agents; Aziridines; Benzamides; Cell Line, Tumor; Human Umbilical Vein Endothelial Cells; Humans; Kinetics; Molecular Docking Simulation; Nitrobenzenes; Nitroreductases; Prodrugs; Staphylococcus saprophyticus

2018