sn 23862 has been researched along with aniline mustard in 15 studies
| Studies (sn 23862) | Trials (sn 23862) | Recent Studies (post-2010) (sn 23862) | Studies (aniline mustard) | Trials (aniline mustard) | Recent Studies (post-2010) (aniline mustard) |
|---|---|---|---|---|---|
| 20 | 0 | 4 | 94 | 1 | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cliffe, S; Denny, WA; Palmer, BD; Wilson, WR | 1 |
| Anlezark, GM; Denny, WA; Friedlos, F; Knox, RJ; Melton, RG; Palmer, BD; Sherwood, RF; Williams, A; Wilson, WR | 1 |
| Denny, WA; Palmer, BD; van Zijl, P; Wilson, WR | 1 |
| Atwell, GJ; Denny, WA; Palmer, BD; Schultz, D; Wilson, WR; Xu, XZ | 1 |
| Baguley, BC; Cliffe, S; Hill, RP; Rutland, M; Taylor, ML; Wilson, WR | 1 |
| Pruijn, FB; Wilson, WR | 1 |
| Anderson, RF; Boyd, M; Denny, WA; Palmer, BD; Wilson, WR | 1 |
| Denny, WA; Lee, HH; Palmer, BD; Wilson, WR | 1 |
| Kestell, P; Palmer, BD; Pruijn, FB; Siim, BG; Wilson, WR | 1 |
| Denny, WA; Helsby, NA; Hicks, KO; Hogg, A; Pullen, SM; Wilson, WR | 1 |
| Denny, WA; Helsby, NA; Palmer, BD; Pruijn, FB; Wheeler, SJ; Wilson, WR; Yang, S | 1 |
| Denny, WA; Johansson, E; Neidle, S; Parkinson, GN | 1 |
| Ferry, DM; Helsby, NA; Patterson, AV; Pullen, SM; Wilson, WR | 1 |
| Çelik, A; Yetiş, G | 1 |
| Ay, M; Celik, A; Gungor, T; Kockar, F; Onder, FC; Tok, TT; Tokay, E; Yetis, G | 1 |
15 other study(ies) available for sn 23862 and aniline mustard
| Article | Year |
|---|---|
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
Topics: Aniline Compounds; Aniline Mustard; Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; CHO Cells; Cricetinae; Humans; Molecular Structure; Mustard Compounds; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxygen; Rats; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured; Water | 1992 |
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Aziridines; Biotransformation; Cell Line; Cricetinae; Escherichia coli; Kinetics; Nitroreductases; Oxidation-Reduction; Prodrugs; Substrate Specificity | 1995 |
Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Topics: Aniline Mustard; Antineoplastic Agents; Cell Division; Cell Line; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Hypoxia; In Vitro Techniques; Nitrogen Mustard Compounds; Oxidation-Reduction; Prodrugs | 1995 |
Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Hypoxia; CHO Cells; Cricetinae; NAD(P)H Dehydrogenase (Quinone); Rats; Structure-Activity Relationship | 1994 |
Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Drug Synergism; Female; Flavonoids; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Regional Blood Flow; Tirapazamine; Triazines; Xanthenes; Xanthones | 1994 |
Hypoxia-activated prodrugs as antitumour agents: strategies for maximizing tumour cell killing.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Hypoxia; Mice; Neoplasms; Nitrogen Mustard Compounds; Prodrugs; Xanthenes; Xanthones | 1995 |
Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Division; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Cricetulus; Crystallography, X-Ray; Isomerism; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cricetinae; Cricetulus; Nitroimidazoles; Tumor Cells, Cultured | 1998 |
Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Aziridines; Biotransformation; Chromatography, High Pressure Liquid; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Prodrugs | 2000 |
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.
Topics: Aniline Mustard; Animals; Aziridines; Bystander Effect; Cell Culture Techniques; Cricetinae; Genetic Therapy; Humans; Neoplasms; Nitroreductases; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
Topics: Aniline Mustard; Animals; Antineoplastic Agents, Alkylating; Aziridines; Chromatography, High Pressure Liquid; Cricetinae; Electrochemistry; Hydrolysis; Kinetics; Mass Spectrometry; Nitroreductases; Prodrugs; Time Factors; Tumor Cells, Cultured | 2003 |
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
Topics: Aniline Mustard; Aziridines; Benzamides; Binding Sites; Crystallography, X-Ray; Dicumarol; Drug Design; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavin Mononucleotide; Models, Molecular; Nitroreductases; Oxidation-Reduction; Prodrugs; Protein Binding | 2003 |
2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.
Topics: Aniline Mustard; Antineoplastic Agents; Aziridines; Bystander Effect; Chromatography, High Pressure Liquid; Escherichia coli; Genetic Therapy; Genetic Vectors; Humans; Mass Spectrometry; Neoplasms; Nitroreductases; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured | 2004 |
An unusually cold active nitroreductase for prodrug activations.
Topics: Aniline Mustard; Aziridines; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Escherichia coli; Flavin Mononucleotide; Hydrogen-Ion Concentration; Mass Spectrometry; Nitrofurazone; Nitroreductases; Phylogeny; Prodrugs; Recombinant Proteins; Staphylococcus saprophyticus; Temperature | 2012 |
Prodrugs for Nitroreductase Based Cancer Therapy- 1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB.
Topics: Aniline Mustard; Antineoplastic Agents; Aziridines; Benzamides; Cell Line, Tumor; Human Umbilical Vein Endothelial Cells; Humans; Kinetics; Molecular Docking Simulation; Nitrobenzenes; Nitroreductases; Prodrugs; Staphylococcus saprophyticus | 2018 |