Compounds > sk&f 99085
Page last updated: 2024-09-05

sk&f 99085 and 25-hydroxycholesterol

sk&f 99085 has been researched along with 25-hydroxycholesterol in 3 studies

Compound Research Comparison

Studies
(sk&f 99085)		Trials
(sk&f 99085)		Recent Studies (post-2010)
(sk&f 99085)		Studies
(25-hydroxycholesterol)		Trials
(25-hydroxycholesterol)		Recent Studies (post-2010) (25-hydroxycholesterol)
15238533243

Protein Interaction Comparison

ProteinTaxonomysk&f 99085 (IC50)25-hydroxycholesterol (IC50)
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHomo sapiens (human)0.3
Sterol regulatory element-binding protein 2Homo sapiens (human)0.3

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Hashimoto, Y; Ohgane, K; Sagimori, I; Yoshioka, H1
Antoni, I; Bentzen, CL; Flach, J; Niesor, EJ; Villemin, P1
Ammon-Zufferey, C; Avner, R; Bentzen, CL; Guyon-Gellin, Y; Masson, D; Niesor, EJ; Perez, A; Roitelman, J1

Other Studies

3 other study(ies) available for sk&f 99085 and 25-hydroxycholesterol

ArticleYear
Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.
    Bioorganic & medicinal chemistry, 2020, 02-01, Volume: 28, Issue:3

    Topics: HEK293 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Lanosterol; Molecular Structure; Oxysterols; Sterol Regulatory Element Binding Proteins; Structure-Activity Relationship

2020
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol.
    Biochemical and biophysical research communications, 2000, Apr-02, Volume: 270, Issue:1

    Topics: Anticholesteremic Agents; Antineoplastic Agents; Apoptosis; Cell Division; Diphosphonates; Dose-Response Relationship, Drug; Farnesol; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Molecular Mimicry; Simvastatin; Terpenes; Tumor Cells, Cultured

2000
Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Animals; Anticholesteremic Agents; Cell-Free System; Cells, Cultured; CHO Cells; Cholesterol; Cricetinae; Diphosphonates; DNA-Binding Proteins; Dose-Response Relationship, Drug; HeLa Cells; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Immunoblotting; Liver; Male; Models, Chemical; Precipitin Tests; Rats; Rats, Wistar; Receptors, LDL; Sterol Regulatory Element Binding Protein 2; Time Factors; Transcription Factors

2004