sk&f 86466 has been researched along with yohimbine in 13 studies
| Studies (sk&f 86466) | Trials (sk&f 86466) | Recent Studies (post-2010) (sk&f 86466) | Studies (yohimbine) | Trials (yohimbine) | Recent Studies (post-2010) (yohimbine) |
|---|---|---|---|---|---|
| 73 | 3 | 9 | 5,893 | 253 | 532 |
| Protein | Taxonomy | sk&f 86466 (IC50) | yohimbine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.02 | |
| D(2) dopamine receptor | Homo sapiens (human) | 2.06 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0428 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0466 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.126 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.013 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.126 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.074 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 1.689 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bondinell, W; Hieble, JP; Ruffolo, RR | 1 |
| Brooks, DP; DePalma, PD; Fredrickson, TA; Hieble, JP; Nichols, AJ; Ruffolo, RR | 1 |
| Downie, JW; Espey, MJ; Gajewski, JB | 1 |
| Gombar, CT; Gutzait, L; Hieble, JP; Sulpizio, AC | 1 |
| Chernesky, CE; Chou, TC; Felsen, D; Marion, DN; Somers, WJ; Vaughan, ED | 1 |
| Daly, RN; DeMarinis, RM; Hieble, JP; Levitt, B; Regan, JW; Ruffolo, RR; Sulpizio, AC | 1 |
| Berlan, M; Lafontan, M; Montastruc, P; Taouis, M | 1 |
| Berlan, M; Galitzky, J; Garrigues, M; Lafontan, M; Rivière, D; Taouis, M | 1 |
| Caron, MG; DeMarinis, RM; Hieble, JP; Holden, KG; Krog, AJ; Lafferty, J; Lefkowitz, RJ; Matthews, WD; Regan, JW; Shah, DH | 1 |
| Szabo, B; Urban, R | 1 |
| Bock, C; Niederhoffer, N; Szabo, B | 1 |
| Bock, C; Niederhoffer, N; Nordheim, U; Szabo, B | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
1 review(s) available for sk&f 86466 and yohimbine
| Article | Year |
|---|---|
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Humans; Molecular Conformation; Molecular Structure; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1995 |
1 trial(s) available for sk&f 86466 and yohimbine
| Article | Year |
|---|---|
Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adult; Benzazepines; Dioxanes; Epinephrine; Exercise; Humans; Idazoxan; Lipid Mobilization; Lipolysis; Male; Yohimbine | 1988 |
11 other study(ies) available for sk&f 86466 and yohimbine
| Article | Year |
|---|---|
Cardiovascular actions of a new selective postjunctional alpha-adrenoceptor antagonist, SK&F 104856, in normotensive and hypertensive dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Dogs; Female; Heart Rate; Hypertension, Renovascular; Male; Myocardial Contraction; Prazosin; Yohimbine | 1992 |
Alpha 2-adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Benzazepines; Cats; Clonidine; Female; Guanabenz; Imidazoline Receptors; Male; Receptors, Adrenergic, alpha; Receptors, Drug; Reflex; Spinal Cord; Yohimbine | 1991 |
Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Desoxycorticosterone; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Hypertension; Male; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1990 |
An in vivo evaluation of alpha adrenergic receptors in canine prostate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Clonidine; Dogs; Dose-Response Relationship, Drug; Epinephrine; Male; Prazosin; Pressure; Prostate; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Evidence for heterogeneity between pre- and postjunctional alpha-2 adrenoceptors using 9-substituted 3-benzazepines.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Guinea Pigs; Humans; In Vitro Techniques; Male; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine | 1988 |
Mechanism of the lipid-mobilizing effect of alpha-2 adrenergic antagonists in the dog.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Benzazepines; Binding, Competitive; Blood Glucose; Cerebral Cortex; Dogs; Fatty Acids, Nonesterified; In Vitro Techniques; Insulin; Lipid Mobilization; Lipolysis; Propranolol; Receptors, Adrenergic, alpha; Yohimbine | 1988 |
Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.
Topics: Affinity Labels; Animals; Benzazepines; Blood Platelets; Cell Membrane; Guinea Pigs; Humans; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Synaptic Transmission; Yohimbine | 1984 |
Mechanism of sympathoinhibition by imidazolines.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1995 |
Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Methyldopa; Norepinephrine; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Clonidine; Decerebrate State; Heart Rate; Imidazoles; Injections, Spinal; Medulla Oblongata; Microinjections; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |