Page last updated: 2024-09-03

sk&f 86466 and prazosin

sk&f 86466 has been researched along with prazosin in 6 studies

Compound Research Comparison

Studies
(sk&f 86466)
Trials
(sk&f 86466)
Recent Studies (post-2010)
(sk&f 86466)
Studies
(prazosin)
Trials
(prazosin)
Recent Studies (post-2010) (prazosin)
73397,914713682

Protein Interaction Comparison

ProteinTaxonomysk&f 86466 (IC50)prazosin (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)5.87
Interstitial collagenaseHomo sapiens (human)4.036
Alpha-2A adrenergic receptorHomo sapiens (human)2.638
Matrix metalloproteinase-9Homo sapiens (human)6.963
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0008
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)0.0078
Alpha-2B adrenergic receptorHomo sapiens (human)0.29
Alpha-2C adrenergic receptorHomo sapiens (human)0.647
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0008
Alpha-1D adrenergic receptorHomo sapiens (human)0.0007
Bromodomain-containing protein 2Homo sapiens (human)0.0009
Alpha-1A adrenergic receptorHomo sapiens (human)0.0006
Alpha-1B adrenergic receptorHomo sapiens (human)0.0006
5-hydroxytryptamine receptor 2BHomo sapiens (human)4.118
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0008
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)9.9
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.5849
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.6

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brooks, DP; DePalma, PD; Fredrickson, TA; Hieble, JP; Nichols, AJ; Ruffolo, RR1
Cagampang, FR; Coen, CW; Maeda, K; Ohkura, S; Ota, K; Tsukamura, H1
Gombar, CT; Gutzait, L; Hieble, JP; Sulpizio, AC1
Chernesky, CE; Chou, TC; Felsen, D; Marion, DN; Somers, WJ; Vaughan, ED1
Daly, RN; DeMarinis, RM; Hieble, JP; Levitt, B; Regan, JW; Ruffolo, RR; Sulpizio, AC1
Denson, DD; Haygood, RM; Hord, AH; Stowe, B1

Other Studies

6 other study(ies) available for sk&f 86466 and prazosin

ArticleYear
Cardiovascular actions of a new selective postjunctional alpha-adrenoceptor antagonist, SK&F 104856, in normotensive and hypertensive dogs.
    British journal of pharmacology, 1992, Volume: 105, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Dogs; Female; Heart Rate; Hypertension, Renovascular; Male; Myocardial Contraction; Prazosin; Yohimbine

1992
Alpha 2-adrenergic receptors are involved in the suppression of luteinizing hormone release during acute fasting in the ovariectomized estradiol-primed rats.
    Neuroendocrinology, 1992, Volume: 56, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Dioxanes; Estradiol; Fasting; Female; Idazoxan; Luteinizing Hormone; Ovariectomy; Piperoxan; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha

1992
Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Desoxycorticosterone; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Hypertension; Male; Prazosin; Rats; Rats, Inbred Strains; Yohimbine

1990
An in vivo evaluation of alpha adrenergic receptors in canine prostate.
    The Journal of urology, 1989, Volume: 141, Issue:5

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Clonidine; Dogs; Dose-Response Relationship, Drug; Epinephrine; Male; Prazosin; Pressure; Prostate; Receptors, Adrenergic, alpha; Yohimbine

1989
Evidence for heterogeneity between pre- and postjunctional alpha-2 adrenoceptors using 9-substituted 3-benzazepines.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Guinea Pigs; Humans; In Vitro Techniques; Male; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine

1988
alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Drug; Hyperalgesia; Male; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley

2001