sk&f 86466 has been researched along with phentolamine in 4 studies
| Studies (sk&f 86466) | Trials (sk&f 86466) | Recent Studies (post-2010) (sk&f 86466) | Studies (phentolamine) | Trials (phentolamine) | Recent Studies (post-2010) (phentolamine) |
|---|---|---|---|---|---|
| 73 | 3 | 9 | 9,141 | 270 | 265 |
| Protein | Taxonomy | sk&f 86466 (IC50) | phentolamine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.396 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.006 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 10 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0316 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.018 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.11 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0492 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0492 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0492 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0316 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.0173 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.359 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.396 | |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | 0.0011 | |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | 0.0108 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 3.807 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0316 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.5495 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caron, MG; DeMarinis, RM; Hieble, JP; Holden, KG; Krog, AJ; Lafferty, J; Lefkowitz, RJ; Matthews, WD; Regan, JW; Shah, DH | 1 |
| DeMarinis, RM; Hieble, JP; Matthews, WD; McCafferty, JP; Roesler, JM | 1 |
| DeMarinis, RM; Hieble, JP; Matthews, WD | 1 |
| Denson, DD; Haygood, RM; Hord, AH; Stowe, B | 1 |
4 other study(ies) available for sk&f 86466 and phentolamine
| Article | Year |
|---|---|
Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.
Topics: Affinity Labels; Animals; Benzazepines; Blood Platelets; Cell Membrane; Guinea Pigs; Humans; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Synaptic Transmission; Yohimbine | 1984 |
Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Heart Rate; Hypertension, Renovascular; Male; Phentolamine; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1986 |
6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine: a potent and selective antagonist of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Benzazepines; Dogs; Epinephrine; Phentolamine | 1983 |
alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Drug; Hyperalgesia; Male; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley | 2001 |