Page last updated: 2024-09-03

sk&f 86466 and idazoxan

sk&f 86466 has been researched along with idazoxan in 8 studies

Compound Research Comparison

Studies (sk&f 86466)	Trials (sk&f 86466)	Recent Studies (post-2010) (sk&f 86466)	Studies (idazoxan)	Trials (idazoxan)	Recent Studies (post-2010) (idazoxan)
73	3	9	1,499	40	123

Protein Interaction Comparison

Protein	Taxonomy	idazoxan (IC50)
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.0083
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.0195
Alpha-2B adrenergic receptor	Homo sapiens (human)	0.0195
Alpha-2C adrenergic receptor	Homo sapiens (human)	0.0537
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.0195
Alpha-1A adrenergic receptor	Homo sapiens (human)	2.884
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.0195

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (12.50)	18.7374
1990's	6 (75.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bondinell, W; Hieble, JP; Ruffolo, RR	1
Berger, SB; Maiese, K; Pek, L; Reis, DJ	1
Cagampang, FR; Coen, CW; Maeda, K; Ohkura, S; Ota, K; Tsukamura, H	1
Berlan, M; Galitzky, J; Garrigues, M; Lafontan, M; Rivière, D; Taouis, M	1
Szabo, B; Urban, R	1
Coles, SK; Dick, TE; Ernsberger, P	1
Colpaert, FC; Pauwels, PJ; Wurch, T	1
Hashimoto, M; Ono, H; Tanabe, M	1

Reviews

1 review(s) available for sk&f 86466 and idazoxan

Article	Year
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Humans; Molecular Conformation; Molecular Structure; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship	1995

Article

Year

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19

Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Humans; Molecular Conformation; Molecular Structure; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship

1995

Trials

1 trial(s) available for sk&f 86466 and idazoxan

Article	Year
Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. European journal of clinical investigation, 1988, Volume: 18, Issue:6 Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adult; Benzazepines; Dioxanes; Epinephrine; Exercise; Humans; Idazoxan; Lipid Mobilization; Lipolysis; Male; Yohimbine	1988

Other Studies

6 other study(ies) available for sk&f 86466 and idazoxan

Article	Year
Reduction in focal cerebral ischemia by agents acting at imidazole receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brain; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Ischemic Attack, Transient; Male; Neurons; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine	1992
Alpha 2-adrenergic receptors are involved in the suppression of luteinizing hormone release during acute fasting in the ovariectomized estradiol-primed rats. Neuroendocrinology, 1992, Volume: 56, Issue:5 Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Dioxanes; Estradiol; Fasting; Female; Idazoxan; Luteinizing Hormone; Ovariectomy; Piperoxan; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha	1992
Mechanism of sympathoinhibition by imidazolines. Annals of the New York Academy of Sciences, 1995, Jul-12, Volume: 763 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine	1995
Post-hypoxic frequency decline does not depend on alpha2-adrenergic receptors in the adult rat. Brain research, 1998, Jun-01, Volume: 794, Issue:2 Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Cerebral Ventricles; Guanabenz; Idazoxan; Infusions, Parenteral; Male; Rats; Rats, Sprague-Dawley; Respiratory Mechanics	1998
G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors. British journal of pharmacology, 1999, Volume: 126, Issue:4 Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; COS Cells; GTP-Binding Proteins; Humans; Idazoxan; Inositol Phosphates; Mice; Mutation; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship	1999
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine	2008