sk&f 86466 has been researched along with clonidine in 20 studies
| Studies (sk&f 86466) | Trials (sk&f 86466) | Recent Studies (post-2010) (sk&f 86466) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 73 | 3 | 9 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | sk&f 86466 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 13 (65.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bondinell, W; Hieble, JP; Ruffolo, RR | 1 |
| Ernsberger, P; Feinland, G; Gomez, RE; Reis, DJ | 1 |
| Downie, JW; Espey, MJ; Gajewski, JB | 1 |
| Ernsberger, P; Giuliano, R; Reis, DJ; Willette, RN | 1 |
| Chernesky, CE; Chou, TC; Felsen, D; Marion, DN; Somers, WJ; Vaughan, ED | 1 |
| Dreshaj, I; Ernsberger, P; Haxhiu, MA; Schäfer, SG | 1 |
| Collins, LA; Dreshaj, IA; Ernsberger, P; Erokwu, B; Haxhiu, MA | 1 |
| Bisgard, GE; Hedrick, MS; Pizarro, J; Ryan, ML | 1 |
| Hieble, JP; Kolpak, DC | 1 |
| Bisgard, GE; Hedrick, MS; Ryan, ML | 1 |
| Fröhlich, R; Illes, P; Szabo, B | 1 |
| Fukiyama, K; Muratani, H; Sesoko, S; Takishita, S; Teruya, H; Yamazato, M | 1 |
| Bock, C; Niederhoffer, N; Nordheim, U; Szabo, B | 1 |
| Bisgard, GE; Herman, JK; O'Halloran, KD | 3 |
| Abdel-Rahman, AA; Li, G; Wang, X | 2 |
| Kaczyñska, K; Szereda-Przestaszewska, M | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
1 review(s) available for sk&f 86466 and clonidine
| Article | Year |
|---|---|
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Humans; Molecular Conformation; Molecular Structure; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1995 |
19 other study(ies) available for sk&f 86466 and clonidine
| Article | Year |
|---|---|
Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.
Topics: Animals; Antihypertensive Agents; Benzazepines; Binding, Competitive; Blood Pressure; Brain Stem; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Imidazoline Receptors; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1991 |
Alpha 2-adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Benzazepines; Cats; Clonidine; Female; Guanabenz; Imidazoline Receptors; Male; Receptors, Adrenergic, alpha; Receptors, Drug; Reflex; Spinal Cord; Yohimbine | 1991 |
Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.
Topics: Animals; Benzazepines; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Drug | 1990 |
An in vivo evaluation of alpha adrenergic receptors in canine prostate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Clonidine; Dogs; Dose-Response Relationship, Drug; Epinephrine; Male; Prazosin; Pressure; Prostate; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Binding, Competitive; Blood Gas Analysis; Blood Pressure; Blood Pressure Determination; Cattle; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Medulla Oblongata; Microinjections; Radioligand Assay; Rats; Rats, Inbred SHR; Receptors, Drug | 1994 |
Effect of I1-imidazoline receptor activation on responses of hypoglossal and phrenic nerve to chemical stimulation.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Benzazepines; Cats; Clonidine; Female; Hypoglossal Nerve; Imidazoline Receptors; Male; Phrenic Nerve; Radioligand Assay; Receptors, Drug; Respiratory System; Stimulation, Chemical | 1995 |
Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Benzazepines; Blood Gas Analysis; Blood Pressure; Carotid Body; Clonidine; Goats; Guanabenz; Heart Rate; Hypercapnia; Phrenic Nerve; Respiration, Artificial; Respiratory Mechanics; Vagotomy | 1994 |
Mediation of the hypotensive action of systemic clonidine in the rat by alpha 2-adrenoceptors.
Topics: Animals; Benzazepines; Blood Pressure; Clonidine; Guanabenz; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug | 1993 |
Recurrent laryngeal nerve activation by alpha 2 adrenergic agonists in goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apnea; Benzazepines; Carbon Dioxide; Chemoreceptor Cells; Clonidine; Goats; Guanabenz; Partial Pressure; Phrenic Nerve; Recurrent Laryngeal Nerve; Respiration; Sodium Cyanide | 1995 |
No evidence for functional imidazoline receptors on locus coeruleus neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Locus Coeruleus; Male; Microelectrodes; Neurons; Oxazoles; Quinolines; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine | 1996 |
Contribution of alpha 2-adrenoceptors in caudal ventrolateral medulla to cardiovascular regulation in rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Cardiovascular Physiological Phenomena; Clonidine; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sympathetic Nervous System | 1998 |
Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Clonidine; Decerebrate State; Heart Rate; Imidazoles; Injections, Spinal; Medulla Oblongata; Microinjections; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apnea; Benzazepines; Clonidine; Electromyography; Female; Goats; Laryngeal Muscles; Lung Volume Measurements; Male; Pharyngeal Muscles; Respiration | 1999 |
Clonidine induces upper airway closure in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apnea; Benzazepines; Clonidine; Consciousness; Diaphragm; Dose-Response Relationship, Drug; Electromyography; Female; Goats; Muscle Contraction; Pharyngeal Muscles; Pressure; Pulmonary Ventilation; Respiration; Respiratory System; Trachea | 2000 |
Ventilatory effects of alpha2-adrenoceptor blockade in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Carotid Body; Clonidine; Denervation; Female; Goats; Heart Rate; Hypercapnia; Hypoxia; Respiration | 2001 |
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Brain Stem; Cerebrospinal Fluid; Clonidine; Consciousness; Gene Expression; Heart Rate; Hydralazine; Hypotension; Imidazoles; Imidazoline Receptors; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Nordefrin; Oxazoles; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; RNA, Messenger; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Postrema; Benzazepines; Benzofurans; Blood Pressure; Clonidine; Consciousness; Heart Rate; Hypotension; Imidazoles; Interleukin-1; Male; Motor Activity; Neurons; Nordefrin; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Rilmenidine; Solitary Nucleus | 2005 |
Clonidine-evoked respiratory effects in anaesthetized rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Benzazepines; Blood Pressure; Carotid Sinus; Clonidine; Dose-Response Relationship, Drug; Injections, Intravenous; Lung; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Respiration; Respiratory Center; Tidal Volume; Time Factors; Vagotomy; Vagus Nerve | 2006 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |