Page last updated: 2024-09-04

sk&f 83959 and sk&f-38393

sk&f 83959 has been researched along with sk&f-38393 in 78 studies

Compound Research Comparison

Studies (sk&f 83959)	Trials (sk&f 83959)	Recent Studies (post-2010) (sk&f 83959)	Studies (sk&f-38393)	Trials (sk&f-38393)	Recent Studies (post-2010) (sk&f-38393)
94	0	46	2,012	29	242

Protein Interaction Comparison

Protein	Taxonomy	sk&f 83959 (IC50)	sk&f-38393 (IC50)
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2		2.8
D	Rattus norvegicus (Norway rat)		0.19

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (8.97)	18.2507
2000's	31 (39.74)	29.6817
2010's	36 (46.15)	24.3611
2020's	4 (5.13)	2.80

Authors

Authors	Studies
Cai, W; Yu, L; Zhang, A; Zhang, H; Zhang, J; Zhen, X	1
Cheng, J; McCorvy, JD; Tan, L; Yan, W	1
Downes, RP; Waddington, JL	1
Deveney, AM; Waddington, JL	1
Clifford, J; Croke, DT; Deveney, AM; Drago, J; Sibley, DR; Tighe, O; Waddington, JL	1
Andringa, G; Cools, AR; Drukarch, B; Stoof, JC; Vermeulen, RJ	1
Andringa, G; Cools, AR; Drukarch, B; Leysen, JE; Stoof, JC	1
Adachi, K; Hasegawa, M; Ikeda, H; Koshikawa, N; Nakamura, S; Waddington, JL	1
Clifford, JJ; Croke, DT; Drago, J; Kinsella, A; Sibley, DR; Tighe, O; Waddington, JL	1
Platt, DM; Rowlett, JK; Spealman, RD	1
Panchalingam, S; Undie, AS	1
Adachi, K; Hasegawa, M; Koshikawa, N; Nakamura, S; Sato, M; Waddington, JL	1
Gerlach, J; Peacock, L	1
Andringa, G; Cools, AR; Lubbers, L; van Oosten, RV	1
Clifford, JJ; Croke, DT; Drago, J; Kinsella, A; Koshikawa, N; McNamara, FN; Tighe, O; Tomiyama, K; Waddington, JL	1
Clifford, JJ; Croke, DT; Drago, J; Fuchs, S; Kinsella, A; McNamara, FN; Tighe, O; Waddington, JL	1
Clifford, JJ; Croke, DT; Drago, J; Kinsella, A; McNamara, FN; Tighe, O; Waddington, JL	1
Cai, G; Friedman, E; Goswami, S; Jin, LQ; Zhen, X	1
Adachi, K; Cools, AR; Fujita, S; Hasegawa, M; Koshikawa, N; Lee, J; Waddington, JL	1
Baldessarini, RJ; Bergman, J; Kula, NS; Neumeyer, JL	1
Kinsella, A; O'Sullivan, GJ; Roth, BL; Waddington, JL	1
Bai, J; Bergson, C; Lidow, MS; Undie, AS; Zhang, L	1
Friedman, E; Goswami, S; Zhen, X	1
Osborn, CV; Wirtshafter, D	1
Croke, DT; Fienberg, AA; Grandy, DK; Kinsella, A; Koshikawa, N; Makihara, Y; Nally, RE; O'Sullivan, G; Sibley, DR; Tighe, O; Tomiyama, K; Waddington, JL; Yamamoto, H	1
Cools, AR; Fujita, S; Kiguchi, M; Koshikawa, N; Lee, J; Uchida, T; Waddington, JL	1
Chen, J; Long, L; Ming, Y; Wang, F; Zhang, H; Zhen, X	1
Bergman, J; Desai, RI; Neumeyer, JL; Nguyen, P; Paronis, CA	1
Chen, J; Ma, L; Wang, F; Zhang, H; Zhen, X	1
Guo, Y; Jin, GZ; Sun, PH; Wang, JR; Yu, Y; Zhang, ZJ; Zhen, X	1
Clementi, M; Croke, DT; Drago, J; Dunleavy, M; Fienberg, AA; Fisone, G; Greengard, P; Hakansson, K; Henshall, DC; Kinsella, A; O'Sullivan, GJ; Sibley, DR; Waddington, JL	1
Able, J; Jandacek, R; Lindquist, DM; McNamara, RK; Rider, T; Tso, P	1
Bateup, HS; Higashi, H; Kuroiwa, M; Nishi, A; Shuto, T; Tanaka, M	1
Chen, X; Yu, L; Zhang, A; Zhang, J; Zhen, X	1
Cai, F; Chen, JG; Huang, C; Liu, J; Long, LH; Ma, LQ; Wang, F; Wang, JH; Wu, WN	1
Croke, DT; Harvey, RP; Kinsella, A; Koshikawa, N; Lai, D; O'Sullivan, GJ; O'Tuathaigh, CM; Tighe, O; Tomiyama, K; Waddington, JL	1
Cai, F; Chen, JG; Fu, H; Gu, J; Liu, C; Liu, J; Ma, LQ; Wang, F; Wang, JH; Xie, N	1
Cai, F; Chen, J; Chen, JG; Hu, ZL; Liu, J; Wang, F; Wang, W; Yang, YJ	1
Ding, F; Gu, X; Li, A; Wang, D; Yin, Y; Zhang, X; Zhen, X; Zhou, J; Zhou, Z	1
Fujita, S; Kiguchi, M; Kinsella, A; Kobayashi, M; Koshikawa, N; Waddington, JL	1
Hirata, M; Kanematsu, T; Kinsella, A; Kobayashi, M; Koshikawa, N; Song, L; Tomiyama, K; Waddington, JL	1
Chu, HY; Hu, GY; Jin, GZ; Yang, Z; Zhao, B; Zhen, X	1
George, SR; Hasbi, A; O'Dowd, BF; Verma, V	1
Chu, HY; Gu, Q; Hu, GY; Jin, GZ; Zhen, X	1
Yang, H; Zhang, L; Zhao, C; Zhao, H	1
Drago, J; Ehrlich, ME; Kim, HA; Kinsella, A; Koshikawa, N; Lawrence, AJ; Schütz, G; Tomiyama, K; Waddington, JL	1
Cao, X; Chu, HY; Hu, GY; Jin, GZ; Wu, Q; Zhang, A; Zhen, X; Zhou, S	1
Kurokawa, K; Mizuno, K; Ohkuma, S	1
George, SR; Jones-Tabah, J; O'Dowd, BF; Perreault, ML	1
Alijaniaram, M; George, SR; Hasbi, A; O'Dowd, BF; Perreault, ML	1
Huang, C; Liao, R; Wu, J; Zhang, W	1
Fan, B; Li, GY; Li, T; Ma, TH; Zheng, YC	1
Guo, L; Jin, G; Wang, G; Zhang, A; Zhao, B; Zhao, J; Zhen, X	1
Chun, LS; Doyle, TB; Free, RB; Huang, XP; Rankin, ML; Sibley, DR	1
Hara, Y; Kato, R; Kinsella, A; Kobayashi, M; Koshikawa, N; Mishina, M; Tomiyama, K; Waddington, JL; Yanagawa, Y	1
Fang, X; Guo, L; Jia, J; Jin, GZ; Li, JQ; Zhang, A; Zhao, B; Zhen, XC; Zheng, YY	1
Fan, T; George, SR; O'Dowd, BF; Perreault, ML	1
Chu, HY; Cui, JM; Jin, GZ; Zhen, XC; Zhou, SL	1
Blake, D; Boyd, K; Kant, A; Lee, SM; Mailman, RB; Murthy, V; Wyrick, SJ	1
Lee, SM; Mailman, RB; Yang, Y	1
Fan, T; George, SR; Perreault, ML; Shen, MY	2
Chen, JG; Deng, ZF; Fang, P; Hu, ZL; Jiang, B; Wang, F; Xiao, JL; Yang, S	1
Biezonski, D; Colbran, RJ; Frederick, AL; Graham, DL; Javitch, JA; Kellendonk, C; Mészáros, J; Sibley, DR; Sonntag, KC; Stanwood, GD; Trifilieff, P; Urizar, E; Vishwasrao, HD; Yano, H	1
Chen, JG; Han, J; Hu, ZL; Long, LH; Ma, J; Ni, L; Wang, F; Wu, PF; Zhang, H	1
Chen, Y; Friedman, E; Guo, L; Wang, G; Zhang, A; Zhao, R; Zhen, X	1
Guo, L; Li, L; Wu, Z; Xu, Z; Zhen, X; Zheng, LT	1
Chapman, CA; Glovaci, I	2
Abraham, AD; Lattal, KM; Neve, KA	1
Angenstein, F; Helbing, C; Tischmeyer, W	1
Cai, L; Guo, YH; Le, WD; Leng, ZG; Lin, SJ; Lou, MQ; Shang, HB; Tang, H; Wu, ZB; Wu, ZR; Xue, YJ; Zhang, X; Zhao, W; Zhao, WG	1
Banasikowski, TJ; Fan, T; George, SR; Grace, AA; Perreault, ML	1
Gao, Q; Gao, S; Gu, Y; Jiang, B; Sheng, G; Zhang, J	1
George, SR; Hasbi, A; Madras, BK; Manduca, JD; Miksys, S; Nguyen, T; Perreault, ML; Rahal, H; Tyndale, RF	1
Cheng, X; Guo, J; Huang, S; Huang, XP; Jiang, H; Jiang, Y; Krumm, B; Liu, H; Liu, YF; Mao, C; Melcher, K; Roth, BL; Shen, DD; Wang, L; Wang, Y; Xu, HE; Xu, P; Xu, T; Zhang, C; Zhang, Y; Zhou, XE; Zhuang, Y	1
Le, W; Xu, R; Yang, K	1
Chao, CC; Liao, RM; Liu, PP	1

Reviews

2 review(s) available for sk&f 83959 and sk&f-38393

Article	Year
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. Journal of medicinal chemistry, 2018, 11-21, Volume: 61, Issue:22 Topics: Animals; Drug Discovery; Humans; Ligands; Receptors, G-Protein-Coupled; Signal Transduction; Structure-Activity Relationship	2018
Dopamine D1 receptor signaling: does GαQ-phospholipase C actually play a role? The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agonists; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Receptors, Dopamine D1; Signal Transduction; Type C Phospholipases	2014

Other Studies

76 other study(ies) available for sk&f 83959 and sk&f-38393

Article	Year
'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14 Topics: Animals; Benzazepines; Cell Line; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; Humans; Molecular Structure; Piperazine; Piperazines; Protein Binding; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D1; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship	2009
Grooming and vacuous chewing induced by SK&F 83959, an agonist of dopamine 'D1-like' receptors that inhibits dopamine-sensitive adenylyl cyclase. European journal of pharmacology, 1993, Mar-30, Volume: 234, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Behavior, Animal; Dopamine; Dopamine Agents; Enzyme Activation; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	1993
Pharmacological characterization of behavioural responses to SK&F 83959 in relation to 'D1-like' dopamine receptors not linked to adenylyl cyclase. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Behavior, Animal; Benzamides; Benzazepines; Binding, Competitive; Chromans; Dopamine Agonists; Dopamine Antagonists; Enzyme Induction; Isoquinolines; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Spiperone; Tetrahydroisoquinolines	1995
Behavioral analysis of multiple D1-like dopamine receptor subtypes: new agents and studies in transgenic mice with D1A receptor knockout. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Body Weight; Chromans; Dopamine Agonists; Dopamine Antagonists; Female; Grooming; Mice; Mice, Knockout; Mice, Transgenic; Polymerase Chain Reaction; Receptors, Dopamine D1	1998
Dopamine receptor subtypes as targets for the pharmacotherapy of Parkinson's disease. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Benzazepines; Dopamine Agonists; Haplorhini; Levodopa; Motor Activity; Parkinson Disease, Secondary; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D1	1998
The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors. European journal of pharmacology, 1999, Jan-01, Volume: 364, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Brain; Carrier Proteins; Cells, Cultured; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Electric Stimulation; Humans; In Vitro Techniques; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuroglia; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Dopamine D1; Species Specificity; Symporters	1999
SK&F 83959 and non-cyclase-coupled dopamine D1-like receptors in jaw movements via dopamine D1-like/D2-like receptor synergism. European journal of pharmacology, 1999, Feb-19, Volume: 367, Issue:2-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Anesthesia; Animals; Chromans; Dopamine Agonists; Drug Combinations; Drug Interactions; Jaw; Male; Muscle Contraction; Muscle, Skeletal; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine	1999
Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase. Neuroscience, 1999, Volume: 93, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Brain Chemistry; Chromans; Dopamine Agonists; Female; Grooming; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Receptors, Dopamine D1; Receptors, Dopamine D2	1999
Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Catalepsy; Cocaine; Discrimination Learning; Dopamine Agonists; Dose-Response Relationship, Drug; Male; Muscle Rigidity; Receptors, Dopamine D1; Saimiri	2000
SKF83959 exhibits biochemical agonism by stimulating [(35)S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brain. Neuropharmacology, 2001, Volume: 40, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Brain; Cytidine Diphosphate Diglycerides; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Macaca mulatta; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2001
Ventral striatal vs. accumbal (shell) mechanisms and non-cyclase-coupled dopamine D(1)-like receptors in jaw movements. European journal of pharmacology, 2001, Jul-06, Volume: 423, Issue:2-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzazepines; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intravenous; Injections, Intraventricular; Jaw; Male; Nucleus Accumbens; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Time Factors	2001
Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biological psychiatry, 2001, Oct-01, Volume: 50, Issue:7 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Arousal; Behavior, Animal; Cebus; Cross-Over Studies; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dyskinesia, Drug-Induced; Dystonia; Locomotion; Receptors, Dopamine D1; Stereotyped Behavior	2001
SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology, 2002, Volume: 42, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Antiparkinson Agents; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Male; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine D1; Social Environment; Stereotyped Behavior	2002
Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice. Neuropharmacology, 2002, Volume: 42, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agonists; Facial Muscles; Female; Incisor; Jaw; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Movement; Mutation; Phenethylamines; Phenotype; Receptors, Dopamine D1; Tongue	2002
Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout". Synapse (New York, N.Y.), 2002, Volume: 46, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Dopamine Agonists; Exploratory Behavior; Female; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Phenotype; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3	2002
Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Congenic; Behavior, Animal; Benzamides; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Exploratory Behavior; Habituation, Psychophysiologic; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Mutation; Phenethylamines; Phenotype; Receptors, Dopamine D1; Transgenes	2003
SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. Journal of neurochemistry, 2003, Volume: 85, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzazepines; Binding, Competitive; Brain; Cell Membrane; Dopamine Agonists; Dopamine Antagonists; Flupenthixol; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Hydrolysis; Male; PC12 Cells; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2003
Prefrontal, accumbal [shell] and ventral striatal mechanisms in jaw movements and non-cyclase-coupled dopamine D1-like receptors. European journal of pharmacology, 2003, Jul-18, Volume: 473, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Basal Ganglia; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Injections, Intravenous; Jaw; Male; Movement; Nucleus Accumbens; Prefrontal Cortex; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2003
Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. European journal of pharmacology, 2003, Aug-08, Volume: 474, Issue:2-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Brain; CHO Cells; Cricetinae; Humans; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Structure-Activity Relationship	2003
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography. European journal of pharmacology, 2004, Feb-23, Volume: 486, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzamides; Benzazepines; Binding, Competitive; Dopamine D2 Receptor Antagonists; Male; Mice; Mice, Inbred C57BL; Motor Activity; Radioligand Assay; Receptors, Dopamine D1; Type C Phospholipases	2004
D1 dopamine receptor regulation of the levels of the cell-cycle-controlling proteins, cyclin D, P27 and Raf-1, in cerebral cortical precursor cells is mediated through cAMP-independent pathways. Cerebral cortex (New York, N.Y. : 1991), 2005, Volume: 15, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclin D; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Dopamine Agonists; Female; Membrane Proteins; Mice; Mice, Mutant Strains; Neurons; Pregnancy; Proto-Oncogene Proteins c-raf; Receptors, Dopamine D1; Second Messenger Systems; Tumor Suppressor Proteins	2005
The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959. Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Chemistry; Dopamine Agonists; Dopamine Antagonists; Hippocampus; Inositol 1,4,5-Trisphosphate; Male; Neostriatum; Oxidopamine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Type C Phospholipases	2005
The atypical dopamine D1 receptor agonist SKF 83959 induces striatal Fos expression in rats. European journal of pharmacology, 2005, Dec-28, Volume: 528, Issue:1-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; Brain; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Models, Animal; Motor Activity; Oxidopamine; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction; Sympathectomy, Chemical	2005
Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Chromans; Dopamine and cAMP-Regulated Phosphoprotein 32; Dyskinesia, Drug-Induced; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Receptors, Dopamine D4; Receptors, Dopamine D5; Signal Transduction	2006
Topographical resolution of jaw movements mediated by cyclase- vs. non-cyclase-coupled dopamine D(1)-like receptors: studies with SK&F 83822. European journal of pharmacology, 2006, May-24, Volume: 538, Issue:1-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Analysis of Variance; Animals; Benzamides; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Jaw; Male; Movement; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Time Factors	2006
Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neurons. Journal of neurochemistry, 2006, Volume: 98, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Isoenzymes; Neurons; Phosphatidylinositols; Phospholipase C beta; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Second Messenger Systems; Thapsigargin; Type C Phospholipases	2006
Behavioral effects of the R-(+)- and S-(-)-enantiomers of the dopamine D(1)-like partial receptor agonist SKF 83959 in monkeys. European journal of pharmacology, 2007, Mar-08, Volume: 558, Issue:1-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; Blinking; Conditioning, Psychological; Dopamine Agonists; Male; Receptors, Dopamine D1; Saimiri; Stereoisomerism	2007
Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. Neuropharmacology, 2007, Volume: 53, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Dyskinesia, Drug-Induced; Levodopa; Male; Movement; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Spiperone; Sympatholytics; Time Factors	2007
Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action. Journal of neurochemistry, 2008, Volume: 104, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antioxidants; Cell Survival; Cells, Cultured; Cerebral Cortex; Dopamine Agonists; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Neuroprotective Agents; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2008
Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. Neuropharmacology, 2008, Volume: 54, Issue:7 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 3; Phosphorylation; Reaction Time; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D5; Seizures; Signal Transduction; Threonine; Time Factors	2008
Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. Journal of lipid research, 2009, Volume: 50, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Linolenic Acid; Animals; Animals, Newborn; Docosahexaenoic Acids; Fatty Acids, Omega-3; Female; Inositol; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Pregnancy; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Signal Transduction	2009
Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum. Journal of neurochemistry, 2008, Volume: 107, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cyclosporine; Dopamine Agents; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Models, Biological; Neostriatum; Phosphorylation; Pyrrolidinones; Receptors, Dopamine D1; Signal Transduction; Threonine; Time Factors	2008
Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities. Bioorganic & medicinal chemistry, 2008, Nov-01, Volume: 16, Issue:21 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; CHO Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Agonists; Humans; Kidney; Molecular Structure; Radioligand Assay; Receptors, Dopamine D1; Receptors, Dopamine D2	2008
Activation of phosphatidylinositol-linked novel D1 dopamine receptor contributes to the calcium mobilization in cultured rat prefrontal cortical astrocytes. Cellular and molecular neurobiology, 2009, Volume: 29, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Astrocytes; Calcium Channels; Calcium Signaling; Cells, Cultured; Enzyme Activation; Extracellular Space; Female; Inositol 1,4,5-Trisphosphate; Intracellular Space; Male; Phosphatidylinositols; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction; Type C Phospholipases	2009
Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice. Progress in neuro-psychopharmacology & biological psychiatry, 2009, Mar-17, Volume: 33, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agonists; Jaw; Mice; Mice, Inbred C57BL; Mice, Knockout; Movement; Movement Disorders; Neuregulin-1; Phenotype; Receptors, Dopamine D1; Tongue	2009
Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons. Journal of neurophysiology, 2009, Volume: 101, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Benzazepines; Biophysics; Calcineurin; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Glutamate Decarboxylase; Heparin; Male; Membrane Potentials; Models, Biological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Substance P; Type C Phospholipases	2009
Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses. Neuropharmacology, 2009, Volume: 57, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Chelating Agents; Cyclosporine; Dopamine Agonists; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Type C Phospholipases	2009
Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jun-17, Volume: 29, Issue:24 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Astrocytes; Benzazepines; Calcium Signaling; Cells, Cultured; Culture Media, Conditioned; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Fibroblast Growth Factor 2; Gene Expression Regulation; Inositol 1,4,5-Trisphosphate; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tyrosine 3-Monooxygenase	2009
Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959. European journal of pharmacology, 2010, Apr-25, Volume: 632, Issue:1-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Behavior, Animal; Benzazepines; Face; Grooming; Jaw; Magnetic Resonance Imaging; Male; Movement; Radiography; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1	2010
Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D(1) dopamine receptor agonist SKF 83959. Synapse (New York, N.Y.), 2010, Volume: 64, Issue:9 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Carrier Proteins; Diazepam; Dopamine Agonists; Dose-Response Relationship, Drug; Face; Female; GABA Modulators; Head Movements; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Mouth; Movement; Receptors, Dopamine D1; Vibrissae	2010
Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro. Brain research, 2010, Jul-09, Volume: 1343 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Organ Culture Techniques; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Somatosensory Cortex; Synaptic Transmission	2010
Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2. The Journal of biological chemistry, 2010, Nov-05, Volume: 285, Issue:45 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Calcium; Calcium Signaling; Cell Line; Dopamine Agonists; G-Protein-Coupled Receptor Kinase 2; Gene Knockdown Techniques; Humans; Mice; Neurons; Protein Multimerization; Protein Structure, Tertiary; Receptors, Dopamine D1; Receptors, Dopamine D2; Visual Cortex	2010
Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects. PloS one, 2010, Oct-01, Volume: 5, Issue:10 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Hippocampus; In Vitro Techniques; Membrane Potentials; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats	2010
Calcium-related signaling pathways contributed to dopamine-induced cortical neuron apoptosis. Neurochemistry international, 2011, Volume: 58, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apoptosis; Atrophy; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Dopamine; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Schizophrenia	2011
Phenotypic disruption to orofacial movement topography in conditional mutants with generalized CamKIIa/Cre D1Tox versus striatal-specific DARPP-32/Cre D1Tox ablation of D1 dopamine receptor-expressing cells. Synapse (New York, N.Y.), 2011, Volume: 65, Issue:9 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corpus Striatum; Diphtheria Toxin; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Face; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Movement; Movement Disorders; Mutation; Neurons; Peptide Fragments; Phenotype; Receptors, Dopamine D1; Time Factors	2011
SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism. Journal of neuroscience research, 2011, Volume: 89, Issue:8 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cells, Cultured; Excitatory Postsynaptic Potentials; Hippocampus; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Synaptic Transmission	2011
Dopamine D1 receptors regulate type 1 inositol 1,4,5-trisphosphate receptor expression via both AP-1- and NFATc4-mediated transcriptional processes. Journal of neurochemistry, 2012, Volume: 122, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blotting, Western; Calcineurin; Calcium Signaling; Carbazoles; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Chromatin Immunoprecipitation; Cyclic AMP; Dopamine Agonists; Enzyme Inhibitors; Immunohistochemistry; Inositol 1,4,5-Trisphosphate Receptors; Mice; Microscopy, Fluorescence; Neurons; NFATC Transcription Factors; Pyrroles; Receptors, Dopamine D1; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic	2012
A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Dopamine Agonists; Gene Expression Regulation; Glutamate Decarboxylase; Glycogen Synthase Kinase 3; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D5; Signal Transduction	2013
Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats. Neuroscience, 2012, Dec-06, Volume: 225 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation, Developmental; Grooming; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2	2012
SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes. PloS one, 2012, Volume: 7, Issue:11 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Astrocytes; Calcium Signaling; Cell Movement; Cells, Cultured; Inositol 1,4,5-Trisphosphate; MAP Kinase Signaling System; Neurons; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Type C Phospholipases	2012
The D₁ dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Molecular vision, 2012, Volume: 18 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Butadienes; Cell Line; Dopamine Agonists; Dopamine Antagonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Receptors, Dopamine D1; Retinal Ganglion Cells; Signal Transduction	2012
SKF83959 is a potent allosteric modulator of sigma-1 receptor. Molecular pharmacology, 2013, Volume: 83, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Allosteric Regulation; Animals; Brain; Cell Line; Drug Synergism; HEK293 Cells; Humans; Liver; Male; Pentazocine; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, sigma; Sigma-1 Receptor	2013
D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms. Molecular pharmacology, 2013, Volume: 84, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Calcium; Calcium Signaling; Cell Line; Dopamine; GTP-Binding Proteins; HEK293 Cells; Humans; Ligands; Receptors, Dopamine D1; Receptors, Dopamine D2	2013
Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluRε1/2/4] subtypes and the GABA synthesizing enzyme GAD65. Neuroscience, 2013, Oct-10, Volume: 250 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acids; Animals; Dopamine Agonists; Facial Muscles; Female; Genotype; Glutamate Decarboxylase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Mouth; Movement; Mutation; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Synaptic Transmission	2013
SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity. Acta pharmacologica Sinica, 2013, Volume: 34, Issue:9 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; CHO Cells; Cricetinae; Cricetulus; Depression; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred C57BL; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins	2013
Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience, 2013, Volume: 35, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Animals; Brain-Derived Neurotrophic Factor; Caudate Nucleus; Dopamine Agonists; Male; Neurons; Nucleus Accumbens; Phosphorylation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkB; Signal Transduction	2013
Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study. Acta pharmacologica Sinica, 2014, Volume: 35, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Dopamine Agonists; Hippocampus; Models, Neurological; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Voltage-Gated Sodium Channels	2014
SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C. Neuropharmacology, 2014, Volume: 86 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Arrestins; beta-Arrestins; Brain; CHO Cells; Cricetulus; Dopamine Agents; HEK293 Cells; Humans; Male; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Transfection; Type C Phospholipases	2014
The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. Pharmacology, biochemistry, and behavior, 2015, Volume: 128 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Amphetamine-Related Disorders; Animals; Behavior, Animal; Central Nervous System Stimulants; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Motor Activity; Multiprotein Complexes; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward	2015
Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer. Neuroscience, 2015, Jan-29, Volume: 285 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Brain; Cell Count; Dimerization; Dopamine Agonists; Dopamine Antagonists; Immunohistochemistry; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2	2015
SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway. The international journal of neuropsychopharmacology, 2014, Dec-07, Volume: 18, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Disease; Depression; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Hippocampus; Inositol 1,4,5-Trisphosphate; Male; Membrane Glycoproteins; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Receptors, Dopamine D5; RNA Interference; RNA, Small Interfering; Signal Transduction; Social Behavior; Stress, Psychological; Type C Phospholipases	2014
Evidence against dopamine D1/D2 receptor heteromers. Molecular psychiatry, 2015, Volume: 20, Issue:11 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Grooming; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Motor Activity; Nucleus Accumbens; Phosphorylation; Protein Multimerization; Protein Structure, Tertiary; Receptors, Dopamine D1; Receptors, Dopamine D2	2015
Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain research, 2015, Jul-30, Volume: 1615 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Neurons; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction; Type C Phospholipases; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels	2015
Allosteric modulation of sigma-1 receptors elicits anti-seizure activities. British journal of pharmacology, 2015, Volume: 172, Issue:16 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anticonvulsants; Benzazepines; Hippocampus; Male; Mice, Inbred C57BL; Motor Activity; Rats, Sprague-Dawley; Receptors, sigma; Seizures; Sigma-1 Receptor	2015
Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation. Journal of neurochemistry, 2015, Volume: 134, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Allosteric Regulation; Animals; Anti-Inflammatory Agents; Cell Line; Culture Media, Conditioned; Dehydroepiandrosterone; Enzyme Induction; Ethylenediamines; Interleukin-10; Ketoconazole; Lipopolysaccharides; Male; Mice; Microglia; Narcotic Antagonists; Neuroblastoma; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase Type II; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, sigma; Sigma-1 Receptor; Tumor Necrosis Factor-alpha	2015
Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex. PloS one, 2015, Volume: 10, Issue:7 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dopamine; Dopamine Agonists; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Phosphatidylinositols; Rats; Rats, Long-Evans; Receptors, Dopamine; Synaptic Transmission	2015
Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:8 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; beta-Arrestins; Cocaine; Conditioning, Classical; Cyclic AMP; Extinction, Psychological; Fear; Male; Mice, Inbred C57BL; Receptors, Dopamine D1; Receptors, Dopamine D5; Reward	2016
Late effect of dopamine D NeuroImage, 2017, 05-15, Volume: 152 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Brain Mapping; Dopamine Agonists; Electric Stimulation; Hippocampus; Magnetic Resonance Imaging; Male; Perforant Pathway; Prefrontal Cortex; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D5	2017
Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. Autophagy, 2017, Aug-03, Volume: 13, Issue:8 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Autophagosomes; Autophagy; Cabergoline; Cell Line, Tumor; Cell Proliferation; Ergolines; Humans; Mice, Nude; Pituitary Neoplasms; Rats; Reactive Oxygen Species; Receptors, Dopamine D5; Superoxide Dismutase; TOR Serine-Threonine Kinases	2017
The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction. The European journal of neuroscience, 2017, Volume: 46, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cognitive Dysfunction; Disease Models, Animal; Dopamine Agonists; Hippocampus; Male; Maze Learning; Nerve Net; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine	2017
SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biological & pharmaceutical bulletin, 2018, Volume: 41, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amnesia; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Carbazoles; Dementia; Hippocampus; Indole Alkaloids; Male; Maze Learning; Memory; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Protein-Tyrosine Kinases; Psychomotor Performance; Scopolamine; Signal Transduction	2018
Dopamine induces release of calcium from internal stores in layer II lateral entorhinal cortex fan cells. Cell calcium, 2019, Volume: 80 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Calcium; Calcium Signaling; Cells, Cultured; Dopamine; Dopamine Agonists; Dopaminergic Neurons; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine D1	2019
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors. Biology of sex differences, 2020, 02-22, Volume: 11, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anxiety; Behavior, Animal; beta Catenin; Brain-Derived Neurotrophic Factor; Caudate Nucleus; Chlorocebus aethiops; Depression; Female; Glycogen Synthase Kinase 3; Male; Nucleus Accumbens; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptor, trkB; Receptors, Dopamine D1; Receptors, Dopamine D2; Sex Characteristics; Signal Transduction	2020
Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 2021, 02-18, Volume: 184, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acid Sequence; Conserved Sequence; Cryoelectron Microscopy; Cyclic AMP; GTP-Binding Proteins; HEK293 Cells; Humans; Ligands; Models, Molecular; Mutant Proteins; Receptors, Adrenergic, beta-2; Receptors, Dopamine D1; Receptors, Dopamine D2; Signal Transduction; Structural Homology, Protein	2021
Dopamine receptor D1 agonist inhibits glioblastoma via calpain‑mediated ER stress and mitochondrial dysfunction. Oncology reports, 2021, Volume: 45, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aged; Animals; Apoptosis; Brain; Brain Neoplasms; Calpain; Cell Line, Tumor; Chemotherapy, Adjuvant; Endoplasmic Reticulum Stress; Female; Glioblastoma; Humans; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Neurosurgical Procedures; Receptors, Dopamine D1; Signal Transduction; Xenograft Model Antitumor Assays	2021
Task-Dependent Effects of SKF83959 on Operant Behaviors Associated With Distinct Changes of CaMKII Signaling in Striatal Subareas. The international journal of neuropsychopharmacology, 2021, 09-21, Volume: 24, Issue:9 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Operant; Dopamine Agonists; Male; Neostriatum; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Dopamine D1	2021