Compounds > sk&f 83959
Page last updated: 2024-09-04

sk&f 83959 and inositol 1,4,5-trisphosphate

sk&f 83959 has been researched along with inositol 1,4,5-trisphosphate in 5 studies

Compound Research Comparison

Studies
(sk&f 83959)		Trials
(sk&f 83959)		Recent Studies (post-2010)
(sk&f 83959)		Studies
(inositol 1,4,5-trisphosphate)		Trials
(inositol 1,4,5-trisphosphate)		Recent Studies (post-2010) (inositol 1,4,5-trisphosphate)
940466,6001589

Protein Interaction Comparison

ProteinTaxonomysk&f 83959 (IC50)inositol 1,4,5-trisphosphate (IC50)
Inositol-trisphosphate 3-kinase ARattus norvegicus (Norway rat)4.45
Inositol 1,4,5-trisphosphate receptor type 2Homo sapiens (human)0.03
Inositol 1,4,5-trisphosphate receptor type 3Homo sapiens (human)0.03
Inositol 1,4,5-trisphosphate receptor type 1Homo sapiens (human)0.03

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Friedman, E; Goswami, S; Zhen, X1
Cai, F; Chen, JG; Huang, C; Liu, J; Long, LH; Ma, LQ; Wang, F; Wang, JH; Wu, WN1
Ding, F; Gu, X; Li, A; Wang, D; Yin, Y; Zhang, X; Zhen, X; Zhou, J; Zhou, Z1
Huang, C; Liao, R; Wu, J; Zhang, W1
Chen, JG; Deng, ZF; Fang, P; Hu, ZL; Jiang, B; Wang, F; Xiao, JL; Yang, S1

Other Studies

5 other study(ies) available for sk&f 83959 and inositol 1,4,5-trisphosphate

ArticleYear
The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Chemistry; Dopamine Agonists; Dopamine Antagonists; Hippocampus; Inositol 1,4,5-Trisphosphate; Male; Neostriatum; Oxidopamine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Type C Phospholipases

2005
Activation of phosphatidylinositol-linked novel D1 dopamine receptor contributes to the calcium mobilization in cultured rat prefrontal cortical astrocytes.
    Cellular and molecular neurobiology, 2009, Volume: 29, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Astrocytes; Calcium Channels; Calcium Signaling; Cells, Cultured; Enzyme Activation; Extracellular Space; Female; Inositol 1,4,5-Trisphosphate; Intracellular Space; Male; Phosphatidylinositols; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Signal Transduction; Type C Phospholipases

2009
Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jun-17, Volume: 29, Issue:24

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Astrocytes; Benzazepines; Calcium Signaling; Cells, Cultured; Culture Media, Conditioned; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Fibroblast Growth Factor 2; Gene Expression Regulation; Inositol 1,4,5-Trisphosphate; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tyrosine 3-Monooxygenase

2009
SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Astrocytes; Calcium Signaling; Cell Movement; Cells, Cultured; Inositol 1,4,5-Trisphosphate; MAP Kinase Signaling System; Neurons; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Type C Phospholipases

2012
SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
    The international journal of neuropsychopharmacology, 2014, Dec-07, Volume: 18, Issue:6

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Disease; Depression; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Hippocampus; Inositol 1,4,5-Trisphosphate; Male; Membrane Glycoproteins; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Receptors, Dopamine D5; RNA Interference; RNA, Small Interfering; Signal Transduction; Social Behavior; Stress, Psychological; Type C Phospholipases

2014