Page last updated: 2024-08-16

sk&f 29661 and ly 134046

sk&f 29661 has been researched along with ly 134046 in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's3 (30.00)18.2507
2000's5 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Jalluri, RK1
Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q2
Borchardt, RT; Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q; Slavica, M; Wang, W1
Criscione, KR; Grunewald, GL; McLeish, MJ1
Archbold, J; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL; McLeish, MJ; McMillan, FM1
Criscione, KR; Grunewald, GL; McLeish, MJ; Wu, Q1
Gee, CL; Grunewald, GL; Lin, F; Martin, JL; McLeish, MJ; Tyndall, JD; Wu, Q1
Coen, CW; Gallo, RV1
Guchhait, RB; Perry, BD; Stolk, JM; U'Prichard, DC; Vantini, G1

Other Studies

10 other study(ies) available for sk&f 29661 and ly 134046

ArticleYear
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.
    Bioorganic & medicinal chemistry letters, 1999, Feb-08, Volume: 9, Issue:3

    Topics: Enzyme Inhibitors; Models, Chemical; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship

1999
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Journal of medicinal chemistry, 1999, Aug-26, Volume: 42, Issue:17

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines

1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Journal of medicinal chemistry, 1999, Sep-09, Volume: 42, Issue:18

    Topics: Adrenal Glands; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Cattle; Clonidine; Enzyme Inhibitors; Fluorine Compounds; Isoquinolines; Models, Molecular; Permeability; Phenylethanolamine N-Methyltransferase

1999
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
    Bioorganic & medicinal chemistry letters, 2001, Jun-18, Volume: 11, Issue:12

    Topics: Animals; Cattle; Epinephrine; Humans; Kinetics; Models, Molecular; Phenylethanolamine N-Methyltransferase; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity

2001
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Journal of medicinal chemistry, 2001, Aug-16, Volume: 44, Issue:17

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Male; Models, Molecular; Phentolamine; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship

2001
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
    Journal of medicinal chemistry, 2004, Jan-01, Volume: 47, Issue:1

    Topics: Benzazepines; Binding Sites; Crystallography, X-Ray; Epinephrine; Humans; Isoquinolines; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Quinolines; S-Adenosylhomocysteine; Substrate Specificity

2004
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.
    Bioorganic & medicinal chemistry letters, 2004, Aug-16, Volume: 14, Issue:16

    Topics: Enzyme Inhibitors; Kinetics; Phenylethanolamine N-Methyltransferase

2004
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
    Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23

    Topics: 2-Hydroxyphenethylamine; Binding Sites; Catalysis; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Mutation; Phenylethanolamine N-Methyltransferase; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydroisoquinolines

2005
Effects of various inhibitors of phenylethanolamine N-methyltransferase on pulsatile release of LH in ovariectomized rats.
    The Journal of endocrinology, 1986, Volume: 111, Issue:1

    Topics: Animals; Benzazepines; Dopamine; Epinephrine; Female; Hypothalamus; Isoquinolines; Luteinizing Hormone; Norepinephrine; Ovariectomy; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines

1986
Assessment of the functional role of brain adrenergic neurons: chronic effects of phenylethanolamine N-methyltransferase inhibitors and alpha adrenergic receptor antagonists on brain norepinephrine metabolism.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Brain; Female; Isoquinolines; Norepinephrine; Phenylethanolamine N-Methyltransferase; Prazosin; Rats; Rats, Inbred F344; Tetrahydroisoquinolines; Tissue Distribution; Tyrosine 3-Monooxygenase; Yohimbine

1984