sk&f 29661 has been researched along with 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (28.57) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL | 1 |
| Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Jalluri, RK | 1 |
| Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q | 2 |
| Borchardt, RT; Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q; Slavica, M; Wang, W | 1 |
| Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Li, Q; McNeil, B | 1 |
| Criscione, KR; Grunewald, GL; McLeish, MJ | 1 |
| Archbold, J; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL; McLeish, MJ; McMillan, FM | 1 |
| Criscione, KR; Grunewald, GL; McLeish, MJ; Wu, Q | 1 |
| Criscione, KR; Grunewald, GL; McLeish, MJ; Romero, FA; Vodonick, SM | 1 |
| Criscione, KR; Grunewald, GL; Romero, FA | 1 |
| Bylund, DB; Criscione, KR; Deupree, JD; Grunewald, GL; Romero, FA; Seim, MR; Spackman, CC | 1 |
| Criscione, KR; Grunewald, GL; Lu, J; Okoro, CO | 1 |
| Gee, CL; Grunewald, GL; Lin, F; Martin, JL; McLeish, MJ; Tyndall, JD; Wu, Q | 1 |
| Criscione, KR; Drinkwater, N; Gee, CL; Grunewald, GL; Martin, JL; Regier, RC; Seim, MR | 1 |
| Criscione, KR; Grunewald, GL; Regier, RC; Seim, MR | 1 |
| Bhat, SR; Criscione, KR; Grunewald, GL; Seim, MR; Wilson, ME | 1 |
| Chisari, A; Johnston, CA; Negro-Vilar, A; Spinedi, E | 1 |
| Coen, CW; Gallo, RV | 1 |
| Guchhait, RB; Perry, BD; Stolk, JM; U'Prichard, DC; Vantini, G | 1 |
| Bondinell, WE; Chapin, FW; Frazee, JS; Gessner, GW; Girard, GR; Hieble, JP; Holden, KG; Kaiser, C; Maryanoff, C; Perchonock, CD | 1 |
| Brunner, H; Chao, P; DiPette, D; Gavras, H; Gavras, I; Volicer, L; Waeber, B | 1 |
| Crowley, WR; Johnson, MD; Terry, LC | 1 |
| Gessner, G; Pendleton, RG; Sawyer, J | 1 |
| Black, J; Bresnahan, MR; Gavras, H; Gavras, I; Waeber, B | 1 |
| Elayan, H; Kennedy, B; Ziegler, MG | 1 |
| Atobe, M; Kariya, T; Kubota, M; Nakagawara, M | 1 |
| Chisari, AN; Gaillard, RC; Giovambattista, A; Spinedi, E | 1 |
1 review(s) available for sk&f 29661 and 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
| Article | Year |
|---|---|
Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: a potential source of new drugs.
Topics: Administration, Oral; Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Epinephrine; Humans; Isoquinolines; Phenylethanolamine N-Methyltransferase; Pyridines; Tetrahydroisoquinolines | 1983 |
27 other study(ies) available for sk&f 29661 and 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
| Article | Year |
|---|---|
Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
Topics: Animals; Clonidine; Enzyme Inhibitors; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 1997 |
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.
Topics: Enzyme Inhibitors; Models, Chemical; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 1999 |
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 1999 |
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenal Glands; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Cattle; Clonidine; Enzyme Inhibitors; Fluorine Compounds; Isoquinolines; Models, Molecular; Permeability; Phenylethanolamine N-Methyltransferase | 1999 |
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Models, Molecular; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Structure-Activity Relationship; Tetrahydroisoquinolines | 1999 |
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Topics: Animals; Cattle; Epinephrine; Humans; Kinetics; Models, Molecular; Phenylethanolamine N-Methyltransferase; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2001 |
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Male; Models, Molecular; Phentolamine; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2001 |
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
Topics: Benzazepines; Binding Sites; Crystallography, X-Ray; Epinephrine; Humans; Isoquinolines; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Quinolines; S-Adenosylhomocysteine; Substrate Specificity | 2004 |
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.
Topics: Enzyme Inhibitors; Kinetics; Phenylethanolamine N-Methyltransferase | 2004 |
Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity tow
Topics: Binding Sites; Blood-Brain Barrier; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 2004 |
3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity.
Topics: Animals; Binding Sites; Biochemistry; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Male; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sensitivity and Specificity; Structure-Activity Relationship; Sulfonamides; Tetrahydroisoquinolines | 2005 |
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Topics: Animals; Binding Sites; Enzyme Inhibitors; Epinephrine; Humans; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2005 |
Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
Topics: Enzyme Inhibitors; Humans; Molecular Structure; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Tetrahydroisoquinolines | 2005 |
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
Topics: 2-Hydroxyphenethylamine; Binding Sites; Catalysis; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Mutation; Phenylethanolamine N-Methyltransferase; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydroisoquinolines | 2005 |
Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
Topics: Animals; Binding Sites; Brain; Crystallography, X-Ray; Humans; Hydrogen Bonding; In Vitro Techniques; Isoquinolines; Male; Models, Molecular; Molecular Structure; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Sulfones | 2006 |
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Topics: Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 2007 |
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Topics: Crystallography, X-Ray; Humans; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Pyridines; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 2008 |
Role of central epinephrine on the regulation of corticotropin-releasing factor and adrenocorticotropin secretion.
Topics: Adrenocorticotropic Hormone; Animals; Benzylamines; Corticotropin-Releasing Hormone; Epinephrine; Ethanolamines; Hypothalamo-Hypophyseal System; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1988 |
Effects of various inhibitors of phenylethanolamine N-methyltransferase on pulsatile release of LH in ovariectomized rats.
Topics: Animals; Benzazepines; Dopamine; Epinephrine; Female; Hypothalamus; Isoquinolines; Luteinizing Hormone; Norepinephrine; Ovariectomy; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1986 |
Assessment of the functional role of brain adrenergic neurons: chronic effects of phenylethanolamine N-methyltransferase inhibitors and alpha adrenergic receptor antagonists on brain norepinephrine metabolism.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Brain; Female; Isoquinolines; Norepinephrine; Phenylethanolamine N-Methyltransferase; Prazosin; Rats; Rats, Inbred F344; Tetrahydroisoquinolines; Tissue Distribution; Tyrosine 3-Monooxygenase; Yohimbine | 1984 |
Salt-induced hypertension in chronic renal failure: evidence for a neurogenic mechanism.
Topics: Animals; Blood Pressure; Body Weight; Brain; Diet; Enzyme Inhibitors; Hypertension; Isoquinolines; Kidney Failure, Chronic; Male; Norepinephrine; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Sodium Chloride; Tetrahydroisoquinolines | 1983 |
Regulation of episodic growth hormone secretion by the central epinephrine system. Studies in the chronically cannulated rat.
Topics: Amines; Animals; Benzylamines; Clonidine; Epinephrine; Growth Hormone; Isoquinolines; Male; Morphine; Periodicity; Phenylethanolamine N-Methyltransferase; Prolactin; Rats; Secretory Rate; Sulfonamides; Tetrahydroisoquinolines | 1982 |
Comparison of the effects of SK & F 29661 and 64139 upon adrenal and cardiac catecholamines.
Topics: Adrenal Glands; Animals; Catecholamines; Dose-Response Relationship, Drug; Heart; Isoquinolines; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Phenylethanolamine N-Methyltransferase; Rats; Sulfonamides; Tetrahydroisoquinolines | 1980 |
Blood pressure response to central and/or peripheral inhibition of phenylethanolamine N-methyltransferase in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Catecholamines; Hypertension; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Rats; Sulfonamides; Tetrahydroisoquinolines | 1981 |
Glucocorticoid hypertension and nonadrenal phenylethanolamine N-methyltransferase.
Topics: Adrenalectomy; Animals; Blood Pressure; Brain; Dexamethasone; Heart Atria; Heart Ventricles; Hypertension; Hypothalamus; Isoquinolines; Male; Medulla Oblongata; Muscles; Myocardium; Organ Specificity; Phenylethanolamine N-Methyltransferase; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines | 1993 |
Effect of phenylethanolamine N-methyltransferase inhibitor, CGS19281A, on the alpha-2-adrenoceptor function in the hypothalamus of rats in comparison with SKF29661, SKF64139 and yohimbine.
Topics: Animals; Carbolines; Clonidine; Hypothalamus; Isoquinolines; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tetrahydroisoquinolines; Yohimbine | 1996 |
Modulatory role of the epinergic system in the neuroendocrine-immune system function.
Topics: Acute-Phase Reaction; Adrenocorticotropic Hormone; Animals; Corticotropin-Releasing Hormone; Enzyme Inhibitors; Epinephrine; Hypoglycemia; Hypothalamo-Hypophyseal System; Isoquinolines; Lipopolysaccharides; Male; Neuroimmunomodulation; Norepinephrine; Phenylethanolamine N-Methyltransferase; Pituitary-Adrenal System; Rats; Rats, Inbred F344; Tetrahydroisoquinolines; Tumor Necrosis Factor-alpha; Vasopressins | 2000 |