Compounds > sk&f 29661
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sk&f 29661 and 3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline

sk&f 29661 has been researched along with 3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Jalluri, RK1
Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q1
Borchardt, RT; Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q; Slavica, M; Wang, W1
Bylund, DB; Criscione, KR; Deupree, JD; Grunewald, GL; Romero, FA; Seim, MR; Spackman, CC1
Criscione, KR; Grunewald, GL; Lu, J; Okoro, CO1
Bhat, SR; Criscione, KR; Grunewald, GL; Seim, MR; Wilson, ME1

Other Studies

6 other study(ies) available for sk&f 29661 and 3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline

ArticleYear
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.
    Bioorganic & medicinal chemistry letters, 1999, Feb-08, Volume: 9, Issue:3

    Topics: Enzyme Inhibitors; Models, Chemical; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship

1999
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Journal of medicinal chemistry, 1999, Aug-26, Volume: 42, Issue:17

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines

1999
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Journal of medicinal chemistry, 1999, Sep-09, Volume: 42, Issue:18

    Topics: Adrenal Glands; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Cattle; Clonidine; Enzyme Inhibitors; Fluorine Compounds; Isoquinolines; Models, Molecular; Permeability; Phenylethanolamine N-Methyltransferase

1999
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
    Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4

    Topics: Animals; Binding Sites; Enzyme Inhibitors; Epinephrine; Humans; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship

2005
Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
    Bioorganic & medicinal chemistry letters, 2005, Dec-01, Volume: 15, Issue:23

    Topics: Enzyme Inhibitors; Humans; Molecular Structure; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Tetrahydroisoquinolines

2005
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
    Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1

    Topics: Crystallography, X-Ray; Humans; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Pyridines; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines

2008