sk&f 29661 has been researched along with 1,2,3,4-tetrahydroisoquinoline in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grunewald, GL; Sall, DJ | 1 |
| Criscione, KR; Dahanukar, VH; Grunewald, GL; Jalluri, RK | 1 |
| Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Jalluri, RK | 1 |
| Criscione, KR; Dahanukar, VH; Grunewald, GL; Teoh, B | 1 |
| Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q | 1 |
| Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Li, Q; McNeil, B | 1 |
| Criscione, KR; Grunewald, GL; McLeish, MJ | 1 |
| Criscione, KR; Drinkwater, N; Gee, CL; Grunewald, GL; Martin, JL; Regier, RC; Seim, MR | 1 |
| Criscione, KR; Grunewald, GL; Regier, RC; Seim, MR | 1 |
| Bhat, SR; Criscione, KR; Grunewald, GL; Seim, MR; Wilson, ME | 1 |
10 other study(ies) available for sk&f 29661 and 1,2,3,4-tetrahydroisoquinoline
| Article | Year |
|---|---|
Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.
Topics: Binding Sites; Isoquinolines; Molecular Conformation; Phenylethanolamine N-Methyltransferase; Structure-Activity Relationship; Tetrahydroisoquinolines | 1987 |
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and th
Topics: Animals; Binding Sites; Brain; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Ligands; Male; Models, Molecular; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Regression Analysis; Structure-Activity Relationship | 1999 |
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.
Topics: Enzyme Inhibitors; Models, Chemical; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 1999 |
3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.
Topics: Adrenal Glands; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Ligands; Male; Models, Molecular; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tetrahydroisoquinolines | 1999 |
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 1999 |
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Models, Molecular; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Structure-Activity Relationship; Tetrahydroisoquinolines | 1999 |
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Topics: Animals; Cattle; Epinephrine; Humans; Kinetics; Models, Molecular; Phenylethanolamine N-Methyltransferase; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2001 |
Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
Topics: Animals; Binding Sites; Brain; Crystallography, X-Ray; Humans; Hydrogen Bonding; In Vitro Techniques; Isoquinolines; Male; Models, Molecular; Molecular Structure; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Sulfones | 2006 |
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Topics: Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 2007 |
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Topics: Crystallography, X-Ray; Humans; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Pyridines; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 2008 |