Compounds > sk&f 104976
Page last updated: 2024-09-03

sk&f 104976 and lanosterol

sk&f 104976 has been researched along with lanosterol in 10 studies

Compound Research Comparison

Studies
(sk&f 104976)		Trials
(sk&f 104976)		Recent Studies (post-2010)
(sk&f 104976)		Studies
(lanosterol)		Trials
(lanosterol)		Recent Studies (post-2010) (lanosterol)
10011,0108335

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's5 (50.00)29.6817
2010's0 (0.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Adams, JL; Berkhout, TA; Bossard, MJ; Mayer, RJ1
Bentzen, C; Berkhout, TA; Jackson, B; Niesor, E; Patel, DD; Simon, HM; Suckling, KE1
Ferruelo, AJ; Gómez-Coronado, D; Lasunción, MA; Martínez-Botas, J; Suárez, Y2
Fernández, C; Ferruelo, AJ; Gómez-Coronado, D; Lasunción, MA; Ledo, B; Martín, M; Suárez, Y; Vega, MA1
Fernández, C; Gómez-Coronado, D; Lasunción, MA; Lobo Md, Mdel V1
Gómez-Mampaso, E; Lasunción, MA; Matilla, J; Montero, MT1
Dávalos, A; de la Peña, G; Fernández-Hernando, C; Lasunción, MA; Martín-Sánchez, C; Sánchez-Martín, CC1
Busto, R; Cano, S; Dávalos, A; de la Peña, G; Giera, M; Herrera, E; Lasunción, MA; Sánchez-Wandelmer, J1
Leaver, DJ; Madan, B; Nes, WD; Virshup, DM1

Reviews

1 review(s) available for sk&f 104976 and lanosterol

ArticleYear
Unearthing the Janus-face cholesterogenesis pathways in cancer.
    Biochemical pharmacology, 2022, Volume: 196

    Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Benzylamines; Cholesterol; Humans; Lanosterol; Neoplasms; Terbinafine; Thiophenes

2022

Other Studies

9 other study(ies) available for sk&f 104976 and lanosterol

ArticleYear
Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells.
    The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30

    Topics: Carcinoma, Hepatocellular; Cell-Free System; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Lanosterol; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxidoreductases; Receptors, LDL; Sterol 14-Demethylase; Sterols; Tumor Cells, Cultured

1991
The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: Acetates; Anticholesteremic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Diphosphonates; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lanosterol; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Receptors, LDL; RNA, Messenger; Transcription, Genetic; Tritium; Tumor Cells, Cultured

1996
Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase.
    Biochimie, 1998, Volume: 80, Issue:11

    Topics: Apoptosis; Cell Division; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Flow Cytometry; Genes, p53; HL-60 Cells; Humans; Lanosterol; Microscopy, Fluorescence; Oxidoreductases; Sterol 14-Demethylase; Time Factors

1998
Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:11

    Topics: CDC2 Protein Kinase; Cell Cycle; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; G2 Phase; Histones; HL-60 Cells; Humans; Lanosterol; Oxidoreductases; Phosphorylation; Sterol 14-Demethylase

1999
Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription.
    European journal of biochemistry, 2002, Volume: 269, Issue:6

    Topics: Base Sequence; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line; Cholesterol; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Ergosterol; Humans; Kinetics; Lanosterol; Transcription, Genetic

2002
Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation.
    Experimental cell research, 2004, Oct-15, Volume: 300, Issue:1

    Topics: Apoptosis; CDC2 Protein Kinase; Cell Nucleus; Cholesterol; Chromosome Aberrations; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; G1 Phase; G2 Phase; Giant Cells; HL-60 Cells; Humans; Lanosterol; Microscopy, Electron, Transmission; Mitosis; Oxidoreductases; Polyploidy; S Phase; Sterol 14-Demethylase

2004
Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Oct-15, Volume: 173, Issue:8

    Topics: Caspase 1; Diterpenes; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; Interferon-gamma; Interleukin-1; Interleukin-18; Lanosterol; Male; Mycobacterium tuberculosis; Th1 Cells

2004
Cholesterol starvation induces differentiation of human leukemia HL-60 cells.
    Cancer research, 2007, Apr-01, Volume: 67, Issue:7

    Topics: Cell Differentiation; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; HL-60 Cells; Humans; Lanosterol; MAP Kinase Signaling System; Oxidoreductases; Sterol 14-Demethylase

2007
Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes.
    Biochimica et biophysica acta, 2009, Volume: 1788, Issue:9

    Topics: 3T3-L1 Cells; Animals; Caveolae; Caveolin 1; Cell Membrane; Cholesterol; Dehydrocholesterols; Enzyme Inhibitors; G(M1) Ganglioside; Lanosterol; Membrane Microdomains; Mice; Receptor, Insulin; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol

2009