sk&f 104078 has been researched along with yohimbine in 13 studies
| Studies (sk&f 104078) | Trials (sk&f 104078) | Recent Studies (post-2010) (sk&f 104078) | Studies (yohimbine) | Trials (yohimbine) | Recent Studies (post-2010) (yohimbine) |
|---|---|---|---|---|---|
| 29 | 0 | 0 | 5,893 | 253 | 532 |
| Protein | Taxonomy | sk&f 104078 (IC50) | yohimbine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.02 | |
| D(2) dopamine receptor | Homo sapiens (human) | 2.06 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0428 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0466 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.126 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.013 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.126 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.074 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 1.689 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bondinell, W; Hieble, JP; Ruffolo, RR | 1 |
| Bondinell, WE; Hieble, JP; Ruffolo, RR | 1 |
| Crosson, CE; DeVries, GW; Heath, AR; Potter, DE | 1 |
| Clarke, RW; Harris, J | 1 |
| Bylund, DB; Ebadi, M; Simonneaux, V | 1 |
| Hieble, JP; Oriowo, MA; Ruffolo, RR | 1 |
| Gleason, MM; Hieble, JP | 1 |
| Gombar, CT; Gutzait, L; Hieble, JP; Sulpizio, AC | 1 |
| Feller, DR; Hamada, A; Miller, DD; Patil, PN; Shams, G; Venkataraman, BV | 1 |
| Medgett, IC; Ruffolo, RR | 1 |
| Daly, RN; DeMarinis, RM; Hieble, JP; Levitt, B; Regan, JW; Ruffolo, RR; Sulpizio, AC | 1 |
| Duda, T; Galoian, K; Sharma, RK; Venkataraman, V | 1 |
| Szreder, Z | 1 |
2 review(s) available for sk&f 104078 and yohimbine
| Article | Year |
|---|---|
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Humans; Molecular Conformation; Molecular Structure; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1995 |
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Topics: Animals; Humans; Molecular Biology; Molecular Structure; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1995 |
11 other study(ies) available for sk&f 104078 and yohimbine
| Article | Year |
|---|---|
Pharmacological evidence for heterogeneity of ocular alpha 2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Cats; Ciliary Body; Cyclic AMP; Dose-Response Relationship, Drug; Iris; Nictitating Membrane; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Yohimbine | 1992 |
An analysis of adrenergic influences on the sural-gastrocnemius reflex of the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Injections, Spinal; Male; Muscles; Prazosin; Rabbits; Reflex; Sural Nerve; Sympathetic Nervous System; Yohimbine | 1992 |
Identification and characterization of alpha 2D-adrenergic receptors in bovine pineal gland.
Topics: Animals; Benzazepines; Cattle; Kinetics; Melatonin; Pineal Gland; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Evidence for heterogeneity of prejunctional alpha-2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Dogs; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Heart Atria; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Saphenous Vein; Synapses; Vas Deferens; Vasoconstriction; Yohimbine | 1991 |
Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Cells, Cultured; Clonidine; Cricetinae; Dibenzazepines; Imidazoles; Indoles; Isoindoles; Lung; Mice; Neuroblastoma; Neurons; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha; Tritium; Tumor Cells, Cultured; Yohimbine | 1991 |
Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Desoxycorticosterone; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Hypertension; Male; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1990 |
Paradoxical effects of isothiocyanate analog of tolazoline on rat aorta and human platelets.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Atrial Function; Benzazepines; Blood Platelets; Calcium; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Isoproterenol; Isothiocyanates; Male; Nifedipine; Phenoxybenzamine; Phentolamine; Phenylephrine; Platelet Activation; Platelet Aggregation; Prazosin; Rats; Rats, Inbred Strains; Temperature; Thiocyanates; Tolazoline; Trachea; Vasoconstriction; Verapamil; Yohimbine | 1989 |
Characterization of alpha-adrenoceptors mediating sympathetic vasoconstriction in rat autoperfused hindlimb: effects of SK&F 104078.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Male; Methoxamine; Perfusion; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Synaptic Transmission; Vasoconstriction; Yohimbine | 1987 |
Evidence for heterogeneity between pre- and postjunctional alpha-2 adrenoceptors using 9-substituted 3-benzazepines.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Guinea Pigs; Humans; In Vitro Techniques; Male; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine | 1988 |
Molecular and pharmacological identity of the alpha 2D-adrenergic receptor subtype in bovine retina and its photoreceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Benzazepines; Cattle; Gene Expression; Humans; Ligands; Mice; Molecular Sequence Data; Oxymetazoline; Photoreceptor Cells; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Retina; Sequence Alignment; Yohimbine | 1996 |
Do cardiovascular mechanisms participate in thermoregulatory activity of alpha 2-adrenoceptor agonists and antagonists in rabbits?
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Body Temperature; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Ear; Energy Metabolism; Fever; Hemodynamics; Lipopolysaccharides; Male; Pyrogens; Quinoxalines; Rabbits; Yohimbine | 1997 |