Page last updated: 2024-09-03

sk&f 104078 and prazosin

sk&f 104078 has been researched along with prazosin in 9 studies

Compound Research Comparison

Studies
(sk&f 104078)
Trials
(sk&f 104078)
Recent Studies (post-2010)
(sk&f 104078)
Studies
(prazosin)
Trials
(prazosin)
Recent Studies (post-2010) (prazosin)
29007,914713682

Protein Interaction Comparison

ProteinTaxonomysk&f 104078 (IC50)prazosin (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)5.87
Interstitial collagenaseHomo sapiens (human)4.036
Alpha-2A adrenergic receptorHomo sapiens (human)2.638
Matrix metalloproteinase-9Homo sapiens (human)6.963
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0008
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)0.0078
Alpha-2B adrenergic receptorHomo sapiens (human)0.29
Alpha-2C adrenergic receptorHomo sapiens (human)0.647
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0008
Alpha-1D adrenergic receptorHomo sapiens (human)0.0007
Bromodomain-containing protein 2Homo sapiens (human)0.0009
Alpha-1A adrenergic receptorHomo sapiens (human)0.0006
Alpha-1B adrenergic receptorHomo sapiens (human)0.0006
5-hydroxytryptamine receptor 2BHomo sapiens (human)4.118
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0008
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)9.9
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.5849
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.6

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's5 (55.56)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bondinell, WE; Hieble, JP; Ruffolo, RR1
Clarke, RW; Harris, J1
Gombar, CT; Gutzait, L; Hieble, JP; Sulpizio, AC1
Grong, K; Hexeberg, E; Lekven, J; Myking, OL; Olweus, J; Westby, J1
Feller, DR; Hamada, A; Miller, DD; Patil, PN; Shams, G; Venkataraman, BV1
Medgett, IC; Ruffolo, RR1
Daly, RN; DeMarinis, RM; Hieble, JP; Levitt, B; Regan, JW; Ruffolo, RR; Sulpizio, AC1
Duda, T; Galoian, K; Sharma, RK; Venkataraman, V1
Cordi, AA; Ragonnet, C; Vayssettes-Courchay, C; Verbeuren, TJ1

Reviews

1 review(s) available for sk&f 104078 and prazosin

ArticleYear
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
    Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18

    Topics: Animals; Humans; Molecular Biology; Molecular Structure; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta

1995

Other Studies

8 other study(ies) available for sk&f 104078 and prazosin

ArticleYear
An analysis of adrenergic influences on the sural-gastrocnemius reflex of the decerebrated rabbit.
    Experimental brain research, 1992, Volume: 92, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Injections, Spinal; Male; Muscles; Prazosin; Rabbits; Reflex; Sural Nerve; Sympathetic Nervous System; Yohimbine

1992
Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Desoxycorticosterone; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Hypertension; Male; Prazosin; Rats; Rats, Inbred Strains; Yohimbine

1990
Blood flow regulation during acute regional ischemia in feline hearts: importance of postjunctional alpha 1- and alpha 2-adrenoceptors.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Catecholamines; Cats; Coronary Circulation; Coronary Disease; Doxazosin; Heart; Male; Myocardium; Oxygen Consumption; Perfusion; Prazosin; Receptors, Adrenergic, alpha; Vascular Resistance

1991
Paradoxical effects of isothiocyanate analog of tolazoline on rat aorta and human platelets.
    Blood vessels, 1989, Volume: 26, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Atrial Function; Benzazepines; Blood Platelets; Calcium; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Isoproterenol; Isothiocyanates; Male; Nifedipine; Phenoxybenzamine; Phentolamine; Phenylephrine; Platelet Activation; Platelet Aggregation; Prazosin; Rats; Rats, Inbred Strains; Temperature; Thiocyanates; Tolazoline; Trachea; Vasoconstriction; Verapamil; Yohimbine

1989
Characterization of alpha-adrenoceptors mediating sympathetic vasoconstriction in rat autoperfused hindlimb: effects of SK&F 104078.
    European journal of pharmacology, 1987, Dec-15, Volume: 144, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Male; Methoxamine; Perfusion; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Synaptic Transmission; Vasoconstriction; Yohimbine

1987
Evidence for heterogeneity between pre- and postjunctional alpha-2 adrenoceptors using 9-substituted 3-benzazepines.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Guinea Pigs; Humans; In Vitro Techniques; Male; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine

1988
Molecular and pharmacological identity of the alpha 2D-adrenergic receptor subtype in bovine retina and its photoreceptors.
    Molecular and cellular biochemistry, 1996, Jun-21, Volume: 159, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Benzazepines; Cattle; Gene Expression; Humans; Ligands; Mice; Molecular Sequence Data; Oxymetazoline; Photoreceptor Cells; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Retina; Sequence Alignment; Yohimbine

1996
In vivo analysis of adrenergic and serotoninergic constrictions of the rabbit saphenous vein.
    European journal of pharmacology, 2000, Nov-24, Volume: 408, Issue:3

    Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Benzazepines; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Indoles; Injections, Intravenous; Isoindoles; Oxadiazoles; Peripheral Nervous System; Phenylephrine; Piperazines; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Serotonin; Saphenous Vein; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Sumatriptan; Tetrahydronaphthalenes; Time Factors; Ultrasonography, Doppler; Vasoconstrictor Agents

2000