Compounds > sk&f 104078
Page last updated: 2024-09-03

sk&f 104078 and nifedipine

sk&f 104078 has been researched along with nifedipine in 2 studies

Compound Research Comparison

Studies
(sk&f 104078)		Trials
(sk&f 104078)		Recent Studies (post-2010)
(sk&f 104078)		Studies
(nifedipine)		Trials
(nifedipine)		Recent Studies (post-2010) (nifedipine)
290016,0242,4961,505

Protein Interaction Comparison

ProteinTaxonomysk&f 104078 (IC50)nifedipine (IC50)
perilipin-5Homo sapiens (human)7.133
perilipin-1Homo sapiens (human)9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)8.376
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.0429
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.035
Cytochrome P450 1A2Homo sapiens (human)0.3
Cytochrome P450 3A4Homo sapiens (human)10
Adenosine receptor A3Homo sapiens (human)7.214
Cytochrome P450 2C9 Homo sapiens (human)3.06
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.214
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0385
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)1.12
Adenosine receptor A1Homo sapiens (human)7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)1.12
C-C chemokine receptor type 2Homo sapiens (human)2.191
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.214
Cytochrome P450 2J2Homo sapiens (human)3.06
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.4733
Voltage-dependent L-type calcium channel subunit alpha-1CMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.035
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0394
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.02
Potassium channel subfamily K member 2 Bos taurus (cattle)8.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)1.5
Voltage-dependent L-type calcium channel subunit alpha-1DMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1FMus musculus (house mouse)1.2

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Feller, DR; Hamada, A; Miller, DD; Patil, PN; Shams, G; Venkataraman, BV1
Hieble, JP; Nichols, AJ; Ruffolo, RR; Sulpizio, AC; Willette, RN1

Other Studies

2 other study(ies) available for sk&f 104078 and nifedipine

ArticleYear
Paradoxical effects of isothiocyanate analog of tolazoline on rat aorta and human platelets.
    Blood vessels, 1989, Volume: 26, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Atrial Function; Benzazepines; Blood Platelets; Calcium; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Isoproterenol; Isothiocyanates; Male; Nifedipine; Phenoxybenzamine; Phentolamine; Phenylephrine; Platelet Activation; Platelet Aggregation; Prazosin; Rats; Rats, Inbred Strains; Temperature; Thiocyanates; Tolazoline; Trachea; Vasoconstriction; Verapamil; Yohimbine

1989
Pharmacologic characterization of SK&F 104078, a novel alpha-2 adrenoceptor antagonist which discriminates between pre- and postjunctional alpha-2 adrenoceptors.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Dogs; Guinea Pigs; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Vasoconstriction

1988