sk&f 100330-a has been researched along with n-(4,4-diphenyl-3-butenyl)nipecotic acid in 12 studies
| Studies (sk&f 100330-a) | Trials (sk&f 100330-a) | Recent Studies (post-2010) (sk&f 100330-a) | Studies (n-(4,4-diphenyl-3-butenyl)nipecotic acid) | Trials (n-(4,4-diphenyl-3-butenyl)nipecotic acid) | Recent Studies (post-2010) (n-(4,4-diphenyl-3-butenyl)nipecotic acid) |
|---|---|---|---|---|---|
| 20 | 0 | 0 | 121 | 0 | 22 |
| Protein | Taxonomy | sk&f 100330-a (IC50) | n-(4,4-diphenyl-3-butenyl)nipecotic acid (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.6918 | |
| Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (human) | 0.165 | |
| Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (house mouse) | 0.4099 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, FE; Bondinell, WE; Dandridge, PA; Frazee, JS; Garvey, E; Girard, GR; Kaiser, C; Ku, TW; Lafferty, JJ; Moonsammy, GI | 1 |
| Faust, MR; Höfner, G; Pabel, J; Wanner, KT | 1 |
| Enna, SJ; Ferkany, JW; Karbon, EW | 1 |
| Falch, E; Krogsgaard-Larsen, P | 1 |
| Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
| Albertson, TE; Joy, RM | 1 |
| Bonanno, G; Raiteri, M | 2 |
| Löscher, W | 1 |
| Löscher, W; Schwark, WS | 1 |
| Enna, SJ; Zorn, SH | 1 |
| Capek, R; Esplin, B | 1 |
12 other study(ies) available for sk&f 100330-a and n-(4,4-diphenyl-3-butenyl)nipecotic acid
| Article | Year |
|---|---|
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Topics: 4-Aminobutyrate Transaminase; Administration, Oral; Alkylation; Amino Acids; Animals; Brain; Carboxylic Acids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1985 |
Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
Topics: Animals; Azetidines; Biological Transport; Cattle; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Structure-Activity Relationship | 2010 |
Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice.
Topics: Animals; Anticonvulsants; Catalepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Receptors, Dopamine; Receptors, GABA-A; Time Factors | 1991 |
GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Structure-Activity Relationship; Synaptosomes | 1989 |
Kinetic characterization of inhibition of gamma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine.
Topics: Animals; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Chemical Phenomena; Chemistry; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Neurons; Nicotinic Acids; Nipecotic Acids; Proline | 1988 |
Increased inhibition in dentate gyrus granule cells following exposure to GABA-uptake blockers.
Topics: Animals; Anticonvulsants; Dimethyl Sulfoxide; Electric Stimulation; Evoked Potentials; GABA Antagonists; Hippocampus; Male; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains | 1987 |
Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Dopamine; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nerve Endings; Nicotinic Acids; Nipecotic Acids; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1987 |
Presence of a gamma-aminobutyric acid (GABA) uptake system on cholinergic terminals of rat hippocampus: evidence for neuronal coexistence of acetylcholine and GABA?
Topics: Acetylcholine; Animals; Choline; Cholinergic Fibers; gamma-Aminobutyric Acid; Hemicholinium 3; Hippocampus; Male; Neurons; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains | 1987 |
Anticonvulsant action in the epileptic gerbil of novel inhibitors of GABA uptake.
Topics: Animals; Anticonvulsants; Depression, Chemical; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Male; Nicotinic Acids; Nipecotic Acids | 1985 |
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains; Seizures | 1985 |
GABA uptake inhibitors produce a greater antinociceptive response in the mouse tail-immersion assay than other types of GABAergic drugs.
Topics: Analgesics; Animals; Biological Transport; Brain; Corpus Striatum; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Nicotinic Acids; Nipecotic Acids; Oxotremorine; Pain; Tail | 1985 |
Frequency-dependent enhancement of hippocampal inhibition by GABA uptake blockers.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Nicotinic Acids; Nipecotic Acids; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |